Skip to main content

Research Repository

Advanced Search

All Outputs (7)

Decreased interferon-? induced STAT-4 activation in immune cells and clinical outcome in multiple sclerosis (2016)
Journal Article
Tanasescu, R., Midgley, A., Robins, R. A., & Constantinescu, C. S. (in press). Decreased interferon-? induced STAT-4 activation in immune cells and clinical outcome in multiple sclerosis. Acta Neurologica Scandinavica, https://doi.org/10.1111/ane.12715

Objectives. Interferon-? (IFN-?) is used in the treatment of multiple sclerosis (MS). IFN-? activation of signal transduction and activation of transcription (STAT)-4 is linked to its immunomodulatory effects. Previous studies suggest a type I IFN de... Read More about Decreased interferon-? induced STAT-4 activation in immune cells and clinical outcome in multiple sclerosis.

The future of multiple sclerosis treatments (2016)
Journal Article
Coclitu, C., Constantinescu, C. S., & Tanasescu, R. (in press). The future of multiple sclerosis treatments. Expert Review of Neurotherapeutics, 16(12), https://doi.org/10.1080/14737175.2016.1243056

Introduction. There are not many conditions in which the last few decades have brought such a major change in the landscape of treatments as is the case of multiple sclerosis (MS). A number of disease modifying treatments (DMTs) are presently availab... Read More about The future of multiple sclerosis treatments.

Time- and Region-Specific Season of Birth Effects in Multiple Sclerosis in the United Kingdom (2016)
Journal Article
María Rodríguez Cruz, P., Matthews, L., Boggild, M., Cavey, A., Constantinescu, C. S., Evangelou, N., …Palace, J. (2016). Time- and Region-Specific Season of Birth Effects in Multiple Sclerosis in the United Kingdom. JAMA Neurology, 73(8), 954-960. https://doi.org/10.1001/jamaneurol.2016.1463

Importance: The reports of seasonal variation in the births of people who later develop multiple sclerosis (MS) have been challenged and attributed to the background pattern in the general population, resulting in a false association. Objective:... Read More about Time- and Region-Specific Season of Birth Effects in Multiple Sclerosis in the United Kingdom.

Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices (2016)
Journal Article
Chou, I., Wang, H., Whitehouse, W. P., & Constantinescu, C. S. (in press). Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices. Current Neurology and Neuroscience Reports, 16(7), https://doi.org/10.1007/s11910-016-0663-4

Pediatric multiple sclerosis (MS) represents less than 5% of the MS population, but patients with pediatric-onset disease reach permanent disability at a younger age than adult onset patients. Accurate diagnosis at presentation and optimal long-term... Read More about Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices.

A comparison of phase imaging and quantitative susceptibility mapping in the imaging of multiple sclerosis lesions at ultrahigh field (2016)
Journal Article
Cronin, M. J., Wharton, S., Al-Radaideh, A., Constantinescu, C., Evangelou, N., Bowtell, R. W., & Gowland, P. A. (2016). A comparison of phase imaging and quantitative susceptibility mapping in the imaging of multiple sclerosis lesions at ultrahigh field. Magnetic Resonance Materials in Physics, Biology and Medicine, 29(3), 543-557. https://doi.org/10.1007/s10334-016-0560-5

Objective The aim of this study was to compare the use of high-resolution phase and QSM images acquired at ultra-high field in the investigation of multiple sclerosis (MS) lesions with peripheral rings, and to discuss their usefulness for drawing... Read More about A comparison of phase imaging and quantitative susceptibility mapping in the imaging of multiple sclerosis lesions at ultrahigh field.

Prognostic factors for long-term outcomes in relapsing–remitting multiple sclerosis (2016)
Journal Article
Traboulsee, A. L., Cornelisse, P., Sandberg-Wollheim, M., Uitdehaag, B. M., Kappos, L., Jongen, P. J., …Li, D. K. (2016). Prognostic factors for long-term outcomes in relapsing–remitting multiple sclerosis. Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2, https://doi.org/10.1177/2055217316666406

Objective: The objective of this article is to investigate potential clinical and MRI predictors of long-term outcomes in multiple sclerosis (MS). Methods: This was a post hoc analysis using data from all 382 patients in the PRISMS long-term foll... Read More about Prognostic factors for long-term outcomes in relapsing–remitting multiple sclerosis.