Research Repository

See what's under the surface


Changes in the testing for and incidence of coeliac disease in the UK 2005-2015: a population based cohort study (2018)
Journal Article
West, J., Otete, H., Sultan, A. A., & Crooks, C. J. (in press). Changes in the testing for and incidence of coeliac disease in the UK 2005-2015: a population based cohort study. Epidemiology,

The diagnosis rates of coeliac disease differ substantially between countries. Intriguingly, there has been recent evidence from Olmstead County, USA and Finland that in the last 5-10 years incidence has plateaued or even declined. In most population... Read More

A validation study of the CirCom comorbidity score in an English cirrhosis population using the Clinical Practice Research Datalink (2018)
Journal Article
Crooks, C. J., West, J., & Jepson, P. (2018). A validation study of the CirCom comorbidity score in an English cirrhosis population using the Clinical Practice Research Datalink. Clinical Epidemiology, 2018:10, doi:10.2147/CLEP.S147535. ISSN 1179-1349

Purpose: The CirCom score has been developed from Danish data as a specific measure of comorbidity for cirrhosis to predict all-cause mortality. We compared its performance with the Charlson Comorbidity Index (CCI) in an English cirrhosis population.... Read More

Community acquired pneumonia incidence before and after proton pump inhibitor prescription: population based study (2016)
Journal Article
Othman, F., Crooks, C. J., & Card, T. R. (2016). Community acquired pneumonia incidence before and after proton pump inhibitor prescription: population based study. BMJ, 355, doi:10.1136/bmj.i5813. ISSN 0959-8138

Objective To examine the risk of community acquired pneumonia before and after prescription of proton pump inhibitor (PPI) and assess whether unmeasured confounding explains this association. Design Cohort study and self controlled case series. S... Read More

Proton pump inhibitor prescribing patterns in the UK: a primary care database study (2016)
Journal Article
Othman, F., Card, T. R., & Crooks, C. J. (2016). Proton pump inhibitor prescribing patterns in the UK: a primary care database study. Pharmacoepidemiology and Drug Safety, 25(9), doi:10.1002/pds.4043. ISSN 1053-8569

Purpose: To determine the prevalence and pattern of proton pump inhibitor (PPI) prescription and the practices employed to reduce PPI use in the UK general population. Methods: The UK's Clinical Practice Research Database was used to identify indi... Read More

When are breast cancer patients at highest risk of venous thromboembolism: a cohort study using English healthcare data (2015)
Journal Article
Walker, A. J., West, J., Card, T. R., Crooks, C. J., Kirwan, C. C., & Grainge, M. J. (2015). When are breast cancer patients at highest risk of venous thromboembolism: a cohort study using English healthcare data. Blood, doi:10.1182/blood-2015-01-625582. ISSN 0006-4971

Breast cancer patients are at increased risk of VTE, particularly in the peri-diagnosis period. However, no previous epidemiological studies have investigated the relative impact of breast cancer treatments in a time-dependent manner. We aimed to det... Read More

Causes of death in people with coeliac disease in England compared with the general population: a competing risk analysis (2015)
Journal Article
Abdul Sultan, A., Crooks, C. J., Card, T. R., Tata, L. J., Fleming, K. M., & West, J. (2015). Causes of death in people with coeliac disease in England compared with the general population: a competing risk analysis. Gut, 64(8), doi:10.1136/gutjnl-2014-308285. ISSN 0017-5749

INTRODUCTION: Quantifying excess cause-specific mortality among people with coeliac disease (CD) compared with the general population accounting for competing risks will allow accurate information to be given on risk of death from specific causes.... Read More

Socioeconomic variation in the incidence of childhood coeliac disease in the UK (2015)
Journal Article
Zingone, F., West, J., Crooks, C. J., Fleming, K. M., Card, T. R., Ciacci,, C., & Tata, L. J. (2015). Socioeconomic variation in the incidence of childhood coeliac disease in the UK. Archives of Disease in Childhood, 100(5), doi:10.1136/archdischild-2014-307105. ISSN 0003-9888

BACKGROUND: Serological studies indicate that evidence of coeliac disease (CD) exists in about 1% of all children, but we lack estimates of current diagnostic patterns among children and how they vary by socioeconomic group. METHODS: We identifie... Read More

Incidence and prevalence of celiac disease and dermatitis herpetiformis in the UK over two decades: population-based study (2014)
Journal Article
West, J., Fleming, K. M., Tata, L. J., Card, T. R., & Crooks, C. J. (2014). Incidence and prevalence of celiac disease and dermatitis herpetiformis in the UK over two decades: population-based study. American Journal of Gastroenterology, 109(5), 757-768. doi:10.1038/ajg.2014.55

OBJECTIVES: Few studies have quantified the incidence and prevalence of celiac disease (CD) and dermatitis herpetiformis (DH) nationally and regionally by time and age groups. Understanding this epidemiology is crucial for hypothesizing about causes... Read More

1 and 5 year survival estimates for people with cirrhosis of the liver in England, 1998–2009: a large population study (2014)
Journal Article
Ratib, S., Fleming, K. M., Crooks, C. J., Aithal, G. P., & West, J. (2014). 1 and 5 year survival estimates for people with cirrhosis of the liver in England, 1998–2009: a large population study. Journal of Hepatology, 60(2), doi:10.1016/j.jhep.2013.09.027. ISSN 0168-8278

BACKGROUND & AIMS: Large, population-based studies that have included the full spectrum of cirrhosis estimating survival, taking into account time-at-risk are lacking. We aimed to report 1- and 5-year average survival rates for people with cirrhosis... Read More

Occurrence of liver cirrhosis in England, a cohort study, 1998-2009: a comparison with cancer (2014)
Journal Article
Ratib, S., West, J., Crooks, C. J., & Fleming, K. M. (2014). Occurrence of liver cirrhosis in England, a cohort study, 1998-2009: a comparison with cancer. American Journal of Gastroenterology, 109(2), doi:10.1038/ajg.2013.405. ISSN 0002-9270

OBJECTIVES: There is no routine registration of the occurrence of newly diagnosed cases of cirrhosis in the United Kingdom. This study seeks to determine precise estimates and trends of the incidence of cirrhosis in England, and directly compare the... Read More

Comorbidities affect risk of nonvariceal upper gastrointestinal bleeding (2013)
Journal Article
Crooks, C. J., West, J., & Card, T. R. (2013). Comorbidities affect risk of nonvariceal upper gastrointestinal bleeding. Gastroenterology, 144(7), doi:10.1053/j.gastro.2013.02.040. ISSN 2308-2097

Background & Aims The incidence of upper gastrointestinal bleeding (GIB) has not been reduced despite the decreasing incidence of peptic ulcers, strategies to eradicate Helicobacter pylori infection, and prophylaxis against ulceration from nonsteroi... Read More

Excess long-term mortality following non-variceal upper gastrointestinal bleeding: a population-based cohort study (2013)
Journal Article
Crooks, C. J., Card, T. R., & West, J. (2013). Excess long-term mortality following non-variceal upper gastrointestinal bleeding: a population-based cohort study. PLoS Medicine, 10(4), doi:10.1371/journal.pmed.1001437. ISSN 1549-1277

Background It is unclear whether an upper gastrointestinal bleed is an isolated gastrointestinal event or an indicator of a deterioration in a patient's overall health status. Therefore, we investigated the excess causes of death in individuals afte... Read More