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All Outputs (30)

Coronaviruses: Important Emerging Human Pathogens (2014)
Journal Article
Coleman, C. M., & Frieman, M. B. (2014). Coronaviruses: Important Emerging Human Pathogens. Journal of Virology, 88(10), 5209-5212. https://doi.org/10.1128/JVI.03488-13

The identification of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 reaffirmed the importance of understanding how coronaviruses emerge, infect, and cause disease. By comparing what is known about severe acute respiratory syndrome c... Read More about Coronaviruses: Important Emerging Human Pathogens.

The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling (2014)
Journal Article
Matthews, K. L., Coleman, C. M., van der Meer, Y., Snijder, E. J., & Frieman, M. B. (2014). The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling. Journal of General Virology, 95(4), 874-882. https://doi.org/10.1099/vir.0.062059-0

The recently emerged Middle East respiratory syndrome coronavirus (MERS-CoV), a betacoronavirus, is associated with severe pneumonia and renal failure. The environmental origin of MERS-CoV is as yet unknown; however, its genome sequence is closely re... Read More about The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling.

Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus (2013)
Journal Article
Coleman, C. M., Matthews, K. L., Goicochea, L., & Frieman, M. B. (2014). Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus. Journal of General Virology, 95(PART 2), 408-412. https://doi.org/10.1099/vir.0.060640-0

The Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerging highly pathogenic virus causing almost 50% lethality in infected individuals. The development of a smallanimal model is critical for the understanding of this virus and t... Read More about Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus.

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons (2012)
Journal Article
St Gelais, C., de Silva, S., Amie, S. M., Coleman, C. M., Hoy, H., Hollenbaugh, J. A., …Wu, L. (2012). SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons. Retrovirology, 9(1), https://doi.org/10.1186/1742-4690-9-105

Cellular and Viral Mechanisms of HIV-1 Transmission Mediated by Dendritic Cells (2012)
Book Chapter
Coleman, C. M., St.Gelais, C., & Wu, L. (2012). Cellular and Viral Mechanisms of HIV-1 Transmission Mediated by Dendritic Cells. Springer New York. https://doi.org/10.1007/978-1-4614-4433-6_4

Dendritic cells (DCs) play a key role in the initial infection and cell-to-cell transmission events that occur upon HIV-1 infection. DCs interact closely with CD4+ T cells, the main target of HIV-1 replication. HIV-1 challenged DCs and target CD4+ T... Read More about Cellular and Viral Mechanisms of HIV-1 Transmission Mediated by Dendritic Cells.