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Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection (2019)
Journal Article
Kulcsar, K. A., Coleman, C. M., Beck, S. E., & Frieman, M. B. (2019). Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection. JCI insight, 4(20), 1-18. https://doi.org/10.1172/jci.insight.131774

Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 in Saudi Arabia and has caused over 2400 cases and more than 800 deaths. Epidemiological studies identified diabetes as the primary comorbidity associated with severe or lethal M... Read More about Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection.

Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection (2017)
Journal Article
Frieman, M. B., Coleman, C. M., & Venkataraman, T. (2017). Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection. Journal of Virology, 91(12), https://doi.org/10.1128/jvi.00182-17

© 2017 American Society for Microbiology. All Rights Reserved. Severe acute respiratory syndrome coronavirus (SARS-CoV) is a highly pathogenic respiratory virus that causes morbidity and mortality in humans. After infection with SARS-CoV, the acute l... Read More about Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection.

One-Health: a Safe, Efficient, Dual-Use Vaccine for Humans and Animals against Middle East Respiratory Syndrome Coronavirus and Rabies Virus (2017)
Journal Article
Wirblich, C., Coleman, C. M., Kurup, D., Abraham, T. S., Bernbaum, J. G., Jahrling, P. B., …Schnell, M. J. (2017). One-Health: a Safe, Efficient, Dual-Use Vaccine for Humans and Animals against Middle East Respiratory Syndrome Coronavirus and Rabies Virus. Journal of Virology, 91(2), https://doi.org/10.1128/jvi.02040-16

© 2017 American Society for Microbiology. Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 and is a highly pathogenic respiratory virus. There are no treatment options against MERS-CoV for humans or animals, and there are no la... Read More about One-Health: a Safe, Efficient, Dual-Use Vaccine for Humans and Animals against Middle East Respiratory Syndrome Coronavirus and Rabies Virus.

CD8 + T Cells and Macrophages Regulate Pathogenesis in a Mouse Model of Middle East Respiratory Syndrome (2016)
Journal Article
Coleman, C. M., Sisk, J. M., Halasz, G., Zhong, J., Beck, S. E., Matthews, K. L., …Frieman, M. B. (2017). CD8 + T Cells and Macrophages Regulate Pathogenesis in a Mouse Model of Middle East Respiratory Syndrome. Journal of Virology, 91(1), https://doi.org/10.1128/jvi.01825-16

© 2016 American Society for Microbiology. Middle East respiratory syndrome coronavirus (MERS-CoV) is an important emerging pathogen that was first described in 2012. While the cell surface receptor for MERS-CoV has been identified as dipeptidyl pepti... Read More about CD8 + T Cells and Macrophages Regulate Pathogenesis in a Mouse Model of Middle East Respiratory Syndrome.

Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion (2016)
Journal Article
Coleman, C. M., Sisk, J. M., Mingo, R. M., Nelson, E. A., White, J. M., & Frieman, M. B. (2016). Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion. Journal of Virology, 90(19), 8924-8933. https://doi.org/10.1128/jvi.01429-16

© 2016, American Society for Microbiology. All Rights Reserved. The highly pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) cause significant morbidity and morality. There... Read More about Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion.

Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo (2016)
Journal Article
Defang, G., Luke, T., Wu, H., Zhao, J., Channappanavar, R., Coleman, C. M., …Frieman, M. B. (2016). Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo. Science Translational Medicine, 8(326), 326ra21-326ra21. https://doi.org/10.1126/scitranslmed.aaf1061

Copyright 2016 by the American Association for the Advancement of Science; all rights reserved. As of 13 November 2015, 1618 laboratory-confirmed human cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection, including 579 deaths,... Read More about Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo.

Severe acute respiratory syndrome coronavirus ORF7a inhibits bone marrow stromal antigen 2 virion tethering through a novel mechanism of glycosylation interference (2015)
Journal Article
Taylor, J. K., Coleman, C. M., Postel, S., Sisk, J. M., Bernbaum, J. G., Venkataraman, T., …Frieman, M. B. (2015). Severe acute respiratory syndrome coronavirus ORF7a inhibits bone marrow stromal antigen 2 virion tethering through a novel mechanism of glycosylation interference. Journal of Virology, 89(23), 11820-11833. https://doi.org/10.1128/JVI.02274-15

© 2015, American Society for Microbiology. Severe acute respiratory syndrome (SARS) emerged in November 2002 as a case of atypical pneumonia in China, and the causative agent of SARS was identified to be a novel coronavirus, severe acute respiratory... Read More about Severe acute respiratory syndrome coronavirus ORF7a inhibits bone marrow stromal antigen 2 virion tethering through a novel mechanism of glycosylation interference.

Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection (2015)
Journal Article
Pascal, K. E., Coleman, C. M., Mujica, A. O., Kamat, V., Badithe, A., Fairhurst, J., …Kyratsous, C. A. (2015). Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection. Proceedings of the National Academy of Sciences, 112(28), 8738-8743. https://doi.org/10.1073/pnas.1510830112

© 2015, National Academy of Sciences. All rights reserved. Traditional approaches to antimicrobial drug development are poorly suited to combatting the emergence of novel pathogens. Additionally, the lack of small animal models for these infections h... Read More about Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection.

Growth and quantification of MERS-CoV infection (2015)
Journal Article
Coleman, C. M., & Frieman, M. B. (2015). Growth and quantification of MERS-CoV infection. Current Protocols in Microbiology, 37(1), 15E.2.1-15E.2.9. https://doi.org/10.1002/9780471729259.mc15e02s37

© 2015 by John Wiley & Sons, Inc. Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging highly pathogenic respiratory virus. Although MERS-CoV only emerged in 2012, we and others have developed assays to grow and quantify infectiou... Read More about Growth and quantification of MERS-CoV infection.

Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection (2014)
Journal Article
Dyall, J., Coleman, C. M., Hart, B. J., Venkataraman, T., Holbrook, M. R., Kindrachuk, J., …Frieman, M. B. (2014). Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection. Antimicrobial Agents and Chemotherapy, 58(8), 4885-4893. https://doi.org/10.1128/AAC.03036-14

Outbreaks of emerging infections present health professionals with the unique challenge of trying to select appropriate pharmacologic treatments in the clinic with little time available for drug testing and development. Typically, clinicians are left... Read More about Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection.

Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses (2014)
Journal Article
Weiss, S. R., Adedeji, A. O., Singh, K., Kassim, A., Coleman, C. M., Elliott, R., …Sarafianos, S. G. (2014). Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses. Antimicrobial Agents and Chemotherapy, 58(8), 4894-4898. https://doi.org/10.1128/AAC.02994-14

We have previously shown that SSYA10-001 blocks severe acute respiratory syndrome coronavirus (SARS-CoV) replication by inhibiting SARS-CoV helicase (nsp13). Here, we show that SSYA10-001 also inhibits replication of two other coronaviruses, mouse he... Read More about Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses.

Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice (2014)
Journal Article
Coleman, C. M., Liu, Y. V., Mu, H., Taylor, J. K., Massare, M., Flyer, D. C., …Frieman, M. B. (2014). Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice. Vaccine, 32(26), 3169-3174. https://doi.org/10.1016/j.vaccine.2014.04.016

Development of vaccination strategies for emerging pathogens are particularly challenging because of the sudden nature of their emergence and the long process needed for traditional vaccine development. Therefore, there is a need for development of a... Read More about Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice.

Coronaviruses: Important Emerging Human Pathogens (2014)
Journal Article
Coleman, C. M., & Frieman, M. B. (2014). Coronaviruses: Important Emerging Human Pathogens. Journal of Virology, 88(10), 5209-5212. https://doi.org/10.1128/JVI.03488-13

The identification of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 reaffirmed the importance of understanding how coronaviruses emerge, infect, and cause disease. By comparing what is known about severe acute respiratory syndrome c... Read More about Coronaviruses: Important Emerging Human Pathogens.

Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus (2013)
Journal Article
Coleman, C. M., Matthews, K. L., Goicochea, L., & Frieman, M. B. (2014). Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus. Journal of General Virology, 95(PART 2), 408-412. https://doi.org/10.1099/vir.0.060640-0

The Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerging highly pathogenic virus causing almost 50% lethality in infected individuals. The development of a smallanimal model is critical for the understanding of this virus and t... Read More about Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus.

Cellular and Viral Mechanisms of HIV-1 Transmission Mediated by Dendritic Cells (2012)
Book Chapter
Coleman, C. M., St.Gelais, C., & Wu, L. (2012). Cellular and Viral Mechanisms of HIV-1 Transmission Mediated by Dendritic Cells. Springer New York. https://doi.org/10.1007/978-1-4614-4433-6_4

Dendritic cells (DCs) play a key role in the initial infection and cell-to-cell transmission events that occur upon HIV-1 infection. DCs interact closely with CD4+ T cells, the main target of HIV-1 replication. HIV-1 challenged DCs and target CD4+ T... Read More about Cellular and Viral Mechanisms of HIV-1 Transmission Mediated by Dendritic Cells.