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Engulfment, persistance and fate of Bdellovibrio bacteriovorus predators inside human phagocytic cells informs their future therapeutic potential (2019)
Journal Article
Raghunathan, D., Radford, P. M., Gell, C., Negus, D., Moore, C., Till, R., …Tyson, J. (2019). Engulfment, persistance and fate of Bdellovibrio bacteriovorus predators inside human phagocytic cells informs their future therapeutic potential. Scientific Reports, 9, 1-16. https://doi.org/10.1038/s41598-019-40223-3

In assessing the potential of predatory bacteria, such as Bdellovibrio bacteriovorus, to become live therapeutic agents against bacterial infections, it is crucial to understand and quantify Bdellovibrio host cell interactions at a molecular level. H... Read More about Engulfment, persistance and fate of Bdellovibrio bacteriovorus predators inside human phagocytic cells informs their future therapeutic potential.

Tropomyosin 1: multiple roles in the developing heart and in the formation of congenital heart defects (2017)
Journal Article
England, J., Granados-Riveron, J. T., Polo-Parada, L., Kuriakose, D., Moore, C., Brook, J. D., …Loughna, S. (2017). Tropomyosin 1: multiple roles in the developing heart and in the formation of congenital heart defects. Journal of Molecular and Cellular Cardiology, 106, https://doi.org/10.1016/j.yjmcc.2017.03.006

Tropomyosin 1 (TPM1) is an essential sarcomeric component, stabilising the thin filament and facilitating actin's interaction with myosin. A number of sarcomeric proteins, such as alpha myosin heavy chain, play crucial roles in cardiac development. M... Read More about Tropomyosin 1: multiple roles in the developing heart and in the formation of congenital heart defects.

The family-specific ?4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition (2016)
Journal Article
Patel, J. T., Belsham, H. R., Rathbone, A. J., Wickstead, B., Gell, C., & Friel, C. T. (2016). The family-specific ?4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition. Open Biology, 6(10), Article 160223. https://doi.org/10.1098/rsob.160223

Kinesins that influence the dynamics of microtubule growth and shrinkage require the ability to distinguish between the microtubule end and the microtubule lattice. The microtubule depolymerizing kinesin MCAK has been shown to specifically recognize... Read More about The family-specific ?4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition.