All Outputs (2)

Stereoselective synthesis of highly substituted tetrahydrofurans by diverted carbene O–H insertion reaction (2015)
Journal Article
Nicolle, S. M., Lewis, W., Hayes, C. J., & Moody, C. J. (2015). Stereoselective synthesis of highly substituted tetrahydrofurans by diverted carbene O–H insertion reaction. Angewandte Chemie International Edition, 54(29), 8485-8489. https://doi.org/10.1002/anie.201502484

Copper or rhodium catalyzed reaction of diazocarbonyl compounds with β-hydroxyketones gives highly substituted tetrahydrofurans with excellent diastereoselectivity, under mild conditions, in a single step process that starts as a carbene O–H insertio... Read More about Stereoselective synthesis of highly substituted tetrahydrofurans by diverted carbene O–H insertion reaction.

Alkyl halide-free heteroatom alkylation and epoxidation facilitated by a recyclable polymer-supported oxidant for the in-flow preparation of diazo compounds (2015)
Journal Article
Nicolle, S., Hayes, C., & Moody, C. (2015). Alkyl halide-free heteroatom alkylation and epoxidation facilitated by a recyclable polymer-supported oxidant for the in-flow preparation of diazo compounds. Chemistry - A European Journal, 21(12), 4576-4579. doi:10.1002/chem.201500118

Highly reactive metal carbenes, generated from simple ketones via diazo compounds, including diazo?amides and ?phosphonates, using a recyclable reagent in?flow, are transient but versatile electrophiles for heteroatom alkylation reactions and for epo... Read More about Alkyl halide-free heteroatom alkylation and epoxidation facilitated by a recyclable polymer-supported oxidant for the in-flow preparation of diazo compounds.