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Hip fracture outcomes in patients with COPD (2018)
Journal Article
Buss, L., McKeever, T. M., Nightingale, J., Akyea, R., Ollivere, B., Moppett, I., & Bolton, C. E. (2018). Hip fracture outcomes in patients with COPD. British Journal of Anaesthesia, 121(6), 1377-1379. doi:10.1016/j.bja.2018.09.008 hideArticle Info

Hip fractures are common in patients with COPD and contemporary outcome data is needed. Patients admitted with a hip fracture to one acute trust (2010-2015) were assessed prospectively (UK National Hip Fracture Database audit) and mortality data col... Read More

Socioeconomic deprivation and the outcome of pulmonary rehabilitation in England and Wales (2017)
Journal Article
Steiner, M. C., Lowe, D., Beckford,, K., Blakey, J., Bolton, C. E., Elkin, S., …Singh, S. J. (2017). Socioeconomic deprivation and the outcome of pulmonary rehabilitation in England and Wales. Thorax, 72(6), doi:10.1136/thoraxjnl-2016-209376. ISSN 0040-6376

Background: Pulmonary rehabilitation (PR) improves exercise capacity and health status in patients with COPD, but many patients assessed for PR do not complete therapy. It is unknown whether socioeconomic deprivation associates with rates of completi... Read More

The Ser82 RAGE variant affects lung function and serum RAGE in smokers and sRAGE production in vitro (2016)
Journal Article
Miller, S., Henry, A. P., Hodge, E., Kheirallah, A. K., Billington, C. K., Rimington, T. L., …Sayers, I. (2016). The Ser82 RAGE variant affects lung function and serum RAGE in smokers and sRAGE production in vitro. PLoS ONE, 11(10), doi:10.1371/journal.pone.0164041. ISSN 1932-6203

Introduction Genome-Wide Association Studies have identified associations between lung function measures and Chronic Obstructive Pulmonary Disease (COPD) and chromosome region 6p21 containing the gene for the Advanced Glycation End Product Recepto... Read More

Multiple circulating cytokines are coelevated in chronic obstructive pulmonary disease (2016)
Journal Article
Selvarajah, S., Todd, I., Tighe, P. J., John, M., Bolton, C. E., Harrison, T. W., & Fairclough, L. C. (2016). Multiple circulating cytokines are coelevated in chronic obstructive pulmonary disease. Mediators of Inflammation, 2016, doi:10.1155/2016/3604842. ISSN 0962-9351

Inflammatory biomarkers, including cytokines, are associated with COPD, but the association of particular circulating cytokines with systemic pathology remains equivocal. To investigate this, we developed a protein microarray system to detect multipl... Read More

Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease (2016)
Journal Article
John, M., McKeever, T. M., Haddad, M. A., Hall, I. P., Sayers, I., Cockcroft, J. R., & Bolton, C. E. (2016). Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease. Chronic Respiratory Disease, 13(3), doi:10.1177/1479972316636995. ISSN 1479-9723

With the increased cardiovascular (CV) morbidity and mortality in subjects with chronic obstructive pulmonary disease (COPD), there is a priority to identify those patients at increased risk of cardiovascular disease. Stable patients with COPD (n = 1... Read More

Target renal damage: the microvascular associations of increased aortic stiffness in patients with COPD (2013)
Journal Article
John, M., Hussain, S., Prayle, A., Simms, R., Cockroft, J. R., & Bolton, C. E. (2013). Target renal damage: the microvascular associations of increased aortic stiffness in patients with COPD. Respiratory Research, 14(31), doi:10.1186/1465-9921-14-31. ISSN 1465-9921

Background Although renal impairment has been described in COPD, there is opportunity to evaluate further to determine nature and consider optimal management. Increased aortic stiffness, as seen in COPD, leads to reduced buffering of pulsatile flow.... Read More