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Strategy for tumor selective disruption of androgen receptor function in the spectrum of prostate cancer (2018)
Journal Article
Rosati, R., Polin, L. A., Ducker, C., Li, J., Bao, X., Selvakumar, D., …Ratnam, M. (2018). Strategy for tumor selective disruption of androgen receptor function in the spectrum of prostate cancer. Clinical Cancer Research, doi:10.1158/1078-0432.ccr-18-0982. ISSN 1078-0432

Purpose: Testosterone suppression in prostate cancer (PC) is limited by serious side effects and resistance via restoration of androgen receptor (AR) functionality. ELK1 is required for ARdependent growth in various hormone-dependent and castration r... Read More

Stepwise evolution of Elk-1 in early deuterostomes (2016)
Journal Article
Saxton, J., Ferjentsik, Z., Ducker, C., & Shaw, P. E. (in press). Stepwise evolution of Elk-1 in early deuterostomes. FEBS Journal, 283(6), doi:10.1111/febs.13607. ISSN 1742-464X

Metazoans have multiple ETS paralogues with overlapping or indiscriminate biological functions. Elk- 1, one of three mammalian Ternary Complex Factors (TCFs), is a well-conserved, ETS domain-containing transcriptional regulator of mitogen-responsive... Read More