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Mechanism of subunit interaction at ketosynthase-dehydratase junctions in trans-AT polyketide synthases (2018)
Journal Article
Jenner, M., Kosol, S., Griffiths, D., Prasongpholchai, P., Manzi, L., Barrow, A. S., …Challis, G. (in press). Mechanism of subunit interaction at ketosynthase-dehydratase junctions in trans-AT polyketide synthases. Nature Chemical Biology, 14, doi:10.1038/nchembio.2549. ISSN 1552-4450

Modular polyketide synthases (PKSs) produce numerous structurally complex natural products with diverse applications in medicine and agriculture. They typically consist of several multienzyme subunits that utilize structurally-defined docking domains... Read More

Pharmacovigilance in hospice/palliative care: net effect of haloperidol for nausea or vomiting (2017)
Journal Article
Digges, M., Hussein, A., Wilcock, A., Crawford, G. B., Boland, J. W., Agar, M. R., …Johnson, M. J. (2018). Pharmacovigilance in hospice/palliative care: net effect of haloperidol for nausea or vomiting. Journal of Palliative Medicine, 21(1), doi:10.1089/jpm.2017.0159. ISSN 1096-6218

Background: Haloperidol is widely prescribed as an antiemetic in patients receiving palliative care, but there is limited evidence to support and refine its use. Objective: To explore the immediate and short-term net clinical effects of haloperido... Read More

Open source drug discovery with the Malaria Box Compound collection for neglected diseases and beyond (2016)
Journal Article
Phillips, M. A., Van Voorhis, W. C., Adams, J. H., Adelfio, R., Ahyong, V., Akabas, M. H., …Willis, P. A. (2016). Open source drug discovery with the Malaria Box Compound collection for neglected diseases and beyond. PLoS Pathogens, 12(7), doi:10.1371/journal.ppat.1005763. ISSN 1553-7366

A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still larg... Read More

Large Rayleigh number thermal convection: heat flux predictions and strongly nonlinear solutions (2009)
Journal Article
Chini, G. P., & Cox, S. M. (2009). Large Rayleigh number thermal convection: heat flux predictions and strongly nonlinear solutions. Physics of Fluids, 21, doi:10.1063/1.3210777. ISSN 1070-6631

We investigate the structure of strongly nonlinear Rayleigh–Bénard convection cells in the asymptotic limit of large Rayleigh number and fixed, moderate Prandtl number. Unlike the flows analyzed in prior theoretical studies of infinite Prandtl number... Read More