Research Repository

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Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases (2019)
Journal Article
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. (2019). Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases. BMJ, 364, doi:10.1136/bmj.k4810

Objectives: To assess risk of venous thromboembolism associated with different types of hormone replacement therapy. Design: Two nested case-control studies. Setting: UK general practices contributing to QResearch or Clinical Practice Research... Read More

Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care (2018)
Journal Article
Vinogradova, Y., Coupland, C., Hill, T., & Hippisley-Cox, J. (2018). Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care. BMJ, 362, doi:10.1136/bmj.k2505. ISSN 0959-8138

Objective: To investigate the associations between direct oral anticoagulants (DOACs) and risks of bleeding, ischaemic stroke, venous thromboembolism, and all cause mortality compared with warfarin. Design: Prospective open cohort study. Settin... Read More

Antidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database (2018)
Journal Article
Coupland, C., Hill, T., Morriss, R., Moore, M., Arthur, A., & Hippisley-Cox, J. (2018). Antidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database. BMC Medicine, 16(1), doi:10.1186/s12916-018-1022-x. ISSN 1741-7015

Background: Antidepressants are one of the most commonly prescribed medications in young and middle-aged adults, but there is relatively little information on their safety across a range of adverse outcomes in this age group. This study aimed to asse... Read More

PHysical activity Implementation Study In Community-dwelling AduLts (PHISICAL): study protocol (2018)
Journal Article
Carpenter, H., Audsley, S., Coupland, C., Gladman, J. R., Kendrick, D., Lafond, N., …Orton, E. (in press). PHysical activity Implementation Study In Community-dwelling AduLts (PHISICAL): study protocol. Injury Prevention, doi:10.1136/injuryprev-2017-042627. ISSN 1353-8047

Background: Falls in older people are a leading causes of unintentional injury. Due to an ageing population, injuries are likely to increase unless more is done to reduce older people’s falls risk. In clinical trials, the Falls Management Exercise (F... Read More

Development and validation of QDiabetes-2018 risk prediction algorithm to estimate future risk of type 2 diabetes: cohort study (2017)
Journal Article
Hippisley-Cox, J., & Coupland, C. (2017). Development and validation of QDiabetes-2018 risk prediction algorithm to estimate future risk of type 2 diabetes: cohort study. BMJ, 359, doi:10.1136/bmj.j5019. ISSN 0959-8138

Objectives: To derive and validate updated QDiabetes-2018 prediction algorithms to estimate the 10 year risk of type 2 diabetes in men and women, taking account of potential new risk factors, and to compare their performance with current approaches.... Read More

Development and validation of QMortality risk prediction algorithm to estimate short term risk of death and assess frailty: cohort study (2017)
Journal Article
Hippisley-Cox, J., & Coupland, C. (2017). Development and validation of QMortality risk prediction algorithm to estimate short term risk of death and assess frailty: cohort study. BMJ, 358, doi:10.1136/bmj.j4208. ISSN 0959-8138

Objectives: To derive and validate a risk prediction equation to estimate the short term risk of death, and to develop a classification method for frailty based on risk of death and risk of unplanned hospital admission. Design: Prospective open... Read More

Psychological morbidity and return to work after injury: multicentre cohort study (2017)
Journal Article
Kendrick, D., Dhiman, P., Kellezi, B., Coupland, C., Whitehead, J., Beckett, K., …Morriss, R. (in press). Psychological morbidity and return to work after injury: multicentre cohort study. British Journal of General Practice, doi:10.3399/bjgp17X691673. ISSN 0960-1643

Background: The benefits of work for physical, psychological and financial wellbeing are well documented. Return to work (RTW) after unintentional injury is often delayed, and psychological morbidity may contribute to this delay. The impact of psycho... Read More

Development and validation of risk prediction equations to estimate survival in patients with colorectal cancer: cohort study (2017)
Journal Article
Hippisley-Cox, J., & Coupland, C. (2017). Development and validation of risk prediction equations to estimate survival in patients with colorectal cancer: cohort study. BMJ, 357, doi:10.1136/bmj.j2497. ISSN 0959-8138

Objective: To develop and externally validate risk prediction equations to estimate absolute and conditional survival in patients with colorectal cancer. Design: Cohort study. Setting: General practices in England providing data for the QResea... Read More

Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study (2017)
Journal Article
Hippisley-Cox, J., Coupland, C., & Brindle, P. (2017). Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study. BMJ, 357, doi:10.1136/bmj.j2099. ISSN 0959-8138

Objectives: To develop and validate updated QRISK3 prediction algorithms to estimate the 10 year risk of cardiovascular disease in women and men accounting for potential new risk factors. Design: Prospective open cohort study. Setting: General... Read More

Use of conspicuity aids by cyclists and risk of crashes involving other road users: population based case-control study (2017)
Journal Article
Miller, P., Kendrick, D., Coupland, C., & Coffey, F. (in press). Use of conspicuity aids by cyclists and risk of crashes involving other road users: population based case-control study. Journal of Transport and Health, 7(A), doi:10.1016/j.jth.2017.03.008. ISSN 2214-1405

Background: Cycling can improve health and well-being by reducing inactivity. Concern about collision crashes may be a barrier to participation since collision crashes can lead to significant mortality and morbidity. The conspicuity of cyclists may b... Read More