Research Repository

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Mammalian cell-driven polymerisation of pyrrole (2018)
Journal Article
Sherman, H. G., Jain, A., Hicks, J., Stolnik, S., Alexander, C., & Rawson, F. J. (2018). Mammalian cell-driven polymerisation of pyrrole. ChemBioChem, doi:10.1002/cbic.201800630

A model cancer cell line was used to initiate polymerisation of pyrrole to form the conducting material polypyrrole. The polymerisation was shown to occur via cytosolic exudates rather than via membrane redox sites which normally control the oxidatio... Read More

Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing (2018)
Journal Article
Lovato, T., Taresco, V., Alazzo, A., Sansone, C., Stolnik, S., Alexander, C., & Conte, C. (2018). Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing. Journal of Materials Chemistry B, doi:10.1039/C8TB01215F. ISSN 2050-750X

Here we describe a rapid inkjet formulation method for screening newly-synthesised cationic materials for siRNA delivery into cancer cells. Reduction responsive oligo-β-aminoesters were prepared and evaluated for their ability to condense siRNA into... Read More

Time and cell-dependent effects of endocytosis inhibitors on the internalization of biomolecule markers and nanomaterials (2018)
Journal Article
Sasso, L., Purdie, L., Grabowska, A. M., Jones, A. T., & Alexander, C. (2018). Time and cell-dependent effects of endocytosis inhibitors on the internalization of biomolecule markers and nanomaterials. Journal of Interdisciplinary Nanomedicine, 3(2), doi:10.1002/jin2.39. ISSN 2058-3273

Endocytosis is an essential function of cells, with key roles in the internalisation of nutrients, signal molecules and also drugs. Endocytic processes are therefore widely investigated in the context of drug delivery, and inhibitors of endocytic pat... Read More

Stimuli-responsive prodrug chemistries for drug delivery (2018)
Journal Article
Taresco, V., Alexander, C., Singh, N., & Pearce, A. K. (in press). Stimuli-responsive prodrug chemistries for drug delivery. doi:10.1002/adtp.201800030. ISSN 2366-3987

Research into advanced therapeutic materials is of growing importance worldwide, particularly in the disease areas of infection, neurodegeneration, and oncology. Advances have been made in treating these diverse pathologies but there still remain man... Read More

High-throughput miniaturized screening of nanoparticle formation via inkjet printing (2018)
Journal Article
Styliari, I. D., Conte, C., Pearce, A. K., Hüsler, A., Cavanagh, R. J., Limo, M. J., …Taresco, V. (in press). High-throughput miniaturized screening of nanoparticle formation via inkjet printing. Macromolecular Materials and Engineering, doi:10.1002/mame.201800146. ISSN 1438-7492

The self‐assembly of specific polymers into well‐defined nanoparticles (NPs) is of great interest to the pharmaceutical industry as the resultant materials can act as drug delivery vehicles. In this work, a high‐throughput method to screen the abilit... Read More

Post-modified polypeptides with UCST-type behavior for control of cell attachment in physiological conditions (2018)
Journal Article
Xue, X., Thiagarajan, L., Dixon, J. E., Saunders, B. R., Shakesheff, K. M., & Alexander, C. (2018). Post-modified polypeptides with UCST-type behavior for control of cell attachment in physiological conditions. Materials, 11(1), doi:10.3390/ma11010095. ISSN 1996-1944

Upper Critical Solution Temperature (UCST)-type thermally responsive polypeptides (TRPs) with phase transition temperatures around 37 ◦C in phosphate-buffered saline (PBS) buffer (pH 7.4, 100 mM) were prepared from poly(L-ornithine) hydrobromide and... Read More

Alkyl-modified oligonucleotides as intercalating vehicles for doxorubicin uptake via albumin binding (2017)
Journal Article
Purdie, L., Alexander, C., Spain, S. G., & Magnusson, J. P. (2018). Alkyl-modified oligonucleotides as intercalating vehicles for doxorubicin uptake via albumin binding. Molecular Pharmaceutics, 15(2), doi:10.1021/acs.molpharmaceut.7b00805. ISSN 1543-8384

DNA-based drug delivery vehicles have displayed promise for the delivery of intercalating drugs. Here, we demonstrate that oligonucleotides modified with an alkyl chain can bind to human serum albumin, mimicking the natural binding of fatty acids. Th... Read More

Quantitative analysis of antibiotic usage in British sheep flocks (2017)
Journal Article
Davies, P., Remnant, J. G., Green, M. J., Gascoigne, E., Gibbon, N., Hyde, R., …Corbishley, A. (in press). Quantitative analysis of antibiotic usage in British sheep flocks. Veterinary Record, doi:10.1136/vr.104501. ISSN 0042-4900

The aim of this study was to examine the variation in antibiotic usage between 207 commercial sheep flocks using their veterinary practice prescribing records. Mean and median prescribed mass per population corrected unit (mg/PCU) was 11.38 and 5.95,... Read More