All Outputs (13)

Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers (2016)
Journal Article
England, R. M., Hare, J. I., Barnes, J., Wilson, J., Smith, A., Strittmatter, N., …Ashford, M. B. (2017). Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers. Journal of Controlled Release, 247, https://doi.org/10.1016/j.jconrel.2016.12.034

Irinotecan is used clinically for the treatment of colorectal cancer; however, its utility is limited by its narrow therapeutic index. We describe the use of a generation 5 l-lysine dendrimer that has been part-modified with a polyoxazoline as a drug... Read More about Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers.

New N-acyl amino acid-functionalized biodegradable polyesters for pharmaceutical and biomedical applications (2016)
Journal Article
Taresco, V., Suksiriworapong, J., Styliari, I. D., Argent, R. H., Swainson, S. M., Booth, J., …Garnett, M. C. (in press). New N-acyl amino acid-functionalized biodegradable polyesters for pharmaceutical and biomedical applications. RSC Advances, 6(111), 109401-109405. https://doi.org/10.1039/C6RA21464A

A novel class of biodegradable polyesters has been generated by coupling poly(glycerol adipate) with N-acyl aromatic amino acids. This new set of polymers from this highly versatile polymeric platform may offer unprecedented new opportunities to prod... Read More about New N-acyl amino acid-functionalized biodegradable polyesters for pharmaceutical and biomedical applications.

Amphiphilic block copolymers from a renewable ?-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release (2016)
Journal Article
Kakde, D., Taresco, V., Bansal, K. K., Magennis, E. P., Howdle, S. M., Mantovani, G., …Alexander, C. (in press). Amphiphilic block copolymers from a renewable Ɛ-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release. Journal of Materials Chemistry B, 44, https://doi.org/10.1039/C6TB01839D

Here we describe a methoxy poly(ethyleneglycol)-b-poly(ε-decalactone) (mPEG-b-PεDL) copolymer and investigate the potential of the copolymer as a vehicle for solubilisation and sustained release of indomethacin (IND). The indomethacin loading and rel... Read More about Amphiphilic block copolymers from a renewable ?-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release.

One-pot RAFT and fast polymersomes assembly: a ‘beeline’ from monomers to drug-loaded nanovectors (2016)
Journal Article
Mastrotto, F., Breen, A. F., Sicilia, G., Murdan, S., Johnstone, A. D., Marsh, G. E., …Mantovani, G. (2016). One-pot RAFT and fast polymersomes assembly: a ‘beeline’ from monomers to drug-loaded nanovectors. Polymer Chemistry, 7(44), 6714-6724. https://doi.org/10.1039/C6PY01292B

Rapid and simple routes to functional polymersomes are increasingly needed to expand their clinical or industrial applications. Here we describe a novel strategy where polymersomes are prepared through an in-line process in just a few hours, starting... Read More about One-pot RAFT and fast polymersomes assembly: a ‘beeline’ from monomers to drug-loaded nanovectors.

Synthesis, characterization and evaluation of in vitro toxicity in hepatocytes of linear polyesters with varied aromatic and aliphatic co-monomers (2016)
Journal Article
Kakde, D., Powell, L. G., Bansal, K. K., Howdle, S., Irvine, D., Mantovani, G., …Alexander, C. (2016). Synthesis, characterization and evaluation of in vitro toxicity in hepatocytes of linear polyesters with varied aromatic and aliphatic co-monomers. Journal of Controlled Release, 244(B), https://doi.org/10.1016/j.jconrel.2016.08.003

Polyesters are extensively used in drug delivery because of their controllable biodegradation properties and perceived favorable cytocompatibility. However, new ester-based materials are continually being sought which can be produced from readily acc... Read More about Synthesis, characterization and evaluation of in vitro toxicity in hepatocytes of linear polyesters with varied aromatic and aliphatic co-monomers.

Properties of acyl modified poly(glycerol-adipate) comb-like polymers and their self-assembly into nanoparticles (2016)
Journal Article
Taresco, V., Suksiriworapong, J., Creasey, R., Burley, J. C., Mantovani, G., Alexander, C., & Garnett, M. (2016). Properties of acyl modified poly(glycerol-adipate) comb-like polymers and their self-assembly into nanoparticles. Journal of Polymer Science Part A: Polymer Chemistry, 54(20), 3267-3278. https://doi.org/10.1002/pola.28215

There is an increasing need to develop bio-compatible polymers with an increased range of different physicochemical properties. Poly(glycerol-adipate) (PGA) is a biocompatible, biodegradable amphiphilic polyester routinely produced from divinyl adipa... Read More about Properties of acyl modified poly(glycerol-adipate) comb-like polymers and their self-assembly into nanoparticles.

Dendrimer mediated clustering of bacteria: improved aggregation and evaluation of bacterial response and viability (2016)
Journal Article
Leire, E., Amaral, S. P., Louzao, I., Winzer, K., Alexander, C., Fernandez-Megia, E., & Fernandez-Trillo, F. (2016). Dendrimer mediated clustering of bacteria: improved aggregation and evaluation of bacterial response and viability. Biomaterials Science, 4(6), https://doi.org/10.1039/C6BM00079G

Here, we evaluate how cationic gallic acid-triethylene glycol (GATG) dendrimers interact with bacteria and their potential to develop new antimicrobials. We demonstrate that GATG dendrimers functionalised with primary amines in their periphery can in... Read More about Dendrimer mediated clustering of bacteria: improved aggregation and evaluation of bacterial response and viability.

FDCCS16 molecular simulation of the thermophysical properties and phase behaviour of impure CO2 relevant to CCS (2016)
Journal Article
Cresswell, A. J., Wheatley, R. J., Wilkinson, R. D., & Graham, R. S. (in press). FDCCS16 molecular simulation of the thermophysical properties and phase behaviour of impure CO2 relevant to CCS. Faraday Discussions, 192, https://doi.org/10.1039/C6FD00026F

Impurities from the CCS chain can greatly influence the physical properties of CO2. This has important design, safety and cost implications for the compression, transport and storage of CO2. There is an urgent need to understand and predict the prope... Read More about FDCCS16 molecular simulation of the thermophysical properties and phase behaviour of impure CO2 relevant to CCS.

Influence of polymer size on uptake and cytotoxicity of doxorubicin-loaded DNA–PEG conjugates (2016)
Journal Article
Purdie, L., Alexander, C., Spain, S. G., & Magnusson, J. P. (2016). Influence of polymer size on uptake and cytotoxicity of doxorubicin-loaded DNA–PEG conjugates. Bioconjugate Chemistry, 27(5), https://doi.org/10.1021/acs.bioconjchem.6b00085

Intercalation of drugs into assembled DNA systems offers versatile new mechanisms for controlled drug delivery. However, current systems are becoming increasingly complex, reducing the practicality of large scale production. Here, we demonstrate a mo... Read More about Influence of polymer size on uptake and cytotoxicity of doxorubicin-loaded DNA–PEG conjugates.

Synthesis and in vitro evaluation of polyethylene glycol-paclitaxel conjugates for lung cancer therapy (2016)
Journal Article
Alexander, C., Luo, T., Magnusson, J., Bosquillon, C., Préat, V., Frédérick, R., & Vanbever, R. (2016). Synthesis and in vitro evaluation of polyethylene glycol-paclitaxel conjugates for lung cancer therapy. Pharmaceutical Research, 33(7), 1671-1681. https://doi.org/10.1007/s11095-016-1908-2

Purpose Pulmonary drug delivery is considered an attractive route of drug administration for lung cancer chemotherapy. However, fast clearance mechanisms result in short residence time of small molecule drugs in the lung. Therefore, achieving a sust... Read More about Synthesis and in vitro evaluation of polyethylene glycol-paclitaxel conjugates for lung cancer therapy.

Variation in structure and properties of poly(glycerol adipate) via control of chain branching during enzymatic synthesis (2016)
Journal Article
Taresco, V., Creasey, R., Kennon, J., Mantovani, G., Alexander, C., Burley, J. C., & Garnett, M. C. (2016). Variation in structure and properties of poly(glycerol adipate) via control of chain branching during enzymatic synthesis. Polymer, 89, https://doi.org/10.1016/j.polymer.2016.02.036

Poly (glycerol adipate) (PGA) can be produced from divinyl adipate and unprotected glycerol by an enzymatic route to generate a polymer with relatively low molar mass (12 kDa). PGA bears a pendant hydroxyl group which imparts a hydrophilic character... Read More about Variation in structure and properties of poly(glycerol adipate) via control of chain branching during enzymatic synthesis.

The effect of protein concentration on the viscosity of a recombinant albumin solution formulation (2016)
Journal Article
Gonçalves, A. D., Alexander, C., Roberts, C. J., Spain, S. G., Uddin, S., & Allen, S. (2016). The effect of protein concentration on the viscosity of a recombinant albumin solution formulation. RSC Advances, 6(18), 15143-15154. https://doi.org/10.1039/c5ra21068b

The effect of protein concentration on solution viscosity in a commercially available biopharmaceutical formulation of recombinant albumin (rAlbumin) was studied. The level of protein aggregation with concentration and its impact on solution viscosit... Read More about The effect of protein concentration on the viscosity of a recombinant albumin solution formulation.

Synthesis of 19F nucleic acid–polymer conjugates as real-time MRI probes of biorecognition (2016)
Journal Article
Sicilia, G., Davis, A. L., Spain, S. G., Magnusson, J. P., Boase, N. R., Thurecht, K. J., & Alexander, C. (2016). Synthesis of 19F nucleic acid–polymer conjugates as real-time MRI probes of biorecognition. Polymer Chemistry, 7(12), 2180-2191. https://doi.org/10.1039/C5PY01883H

Polymer–DNA conjugates in which one nucleic acid strand contains fluorine-substituted nucleobases have been prepared and characterised. The efficacy of these novel 19F nucleic acid–polymer conjugates as sensitive and selective in vitro reporters of D... Read More about Synthesis of 19F nucleic acid–polymer conjugates as real-time MRI probes of biorecognition.