All Outputs (4)

Chain-extension in hyperbranched polymers alters tissue distribution and cytotoxicity profiles in orthotopic models of triple negative breast cancers (2023)
Journal Article
Moloney, C., Mehradnia, F., Cavanagh, R. J., Ibrahim, A., Pearce, A. K., Ritchie, A. A., …Alexander, C. (2023). Chain-extension in hyperbranched polymers alters tissue distribution and cytotoxicity profiles in orthotopic models of triple negative breast cancers. Biomaterials Science, 11, 6545-6560. https://doi.org/10.1039/d3bm00609c

The therapeutic efficacy of nanomedicines is highly dependent on their access to target sites in the body, and this in turn is markedly affected by their size, shape and transport properties in tissue. Although there have been many studies in this ar... Read More about Chain-extension in hyperbranched polymers alters tissue distribution and cytotoxicity profiles in orthotopic models of triple negative breast cancers.

Role of Self‐Assembly Conditions and Amphiphilic Balance on Nanoparticle Formation of PEG‐PDLLA Copolymers in Aqueous Environments (2019)
Journal Article
Phan, H., Minut, R. I., McCrorie, P., Vasey, C., Larder, R. R., Krumins, E., …Pearce, A. K. (2019). Role of Self‐Assembly Conditions and Amphiphilic Balance on Nanoparticle Formation of PEG‐PDLLA Copolymers in Aqueous Environments. Journal of Polymer Science Part A: Polymer Chemistry, 57(17), 1801-1810. https://doi.org/10.1002/pola.29451

The production of well-defined and reproducible poly-meric nanoparticles (NPs), in terms of size and stability in biological environments, is undoubtedly a fundamental challenge in the formulation of novel and more effective nanomedicines. The adopti... Read More about Role of Self‐Assembly Conditions and Amphiphilic Balance on Nanoparticle Formation of PEG‐PDLLA Copolymers in Aqueous Environments.

Time and cell-dependent effects of endocytosis inhibitors on the internalization of biomolecule markers and nanomaterials (2018)
Journal Article
Sasso, L., Purdie, L., Grabowska, A. M., Jones, A. T., & Alexander, C. (2018). Time and cell-dependent effects of endocytosis inhibitors on the internalization of biomolecule markers and nanomaterials. Journal of Interdisciplinary Nanomedicine, 3(2), https://doi.org/10.1002/jin2.39

Endocytosis is an essential function of cells, with key roles in the internalisation of nutrients, signal molecules and also drugs. Endocytic processes are therefore widely investigated in the context of drug delivery, and inhibitors of endocytic pat... Read More about Time and cell-dependent effects of endocytosis inhibitors on the internalization of biomolecule markers and nanomaterials.

Polymers for binding of the gram-positive oral pathogen Streptococcus mutans (2017)
Journal Article
Magennis, E. P., Francini, N., Mastrotto, F., Catania, R., Redhead, M., Fernandez-Trillo, F., …Mantovani, G. (2017). Polymers for binding of the gram-positive oral pathogen Streptococcus mutans. PLoS ONE, 12(7), Article e018008. https://doi.org/10.1371/journal.pone.0180087

Streptococcus mutans is the most significant pathogenic bacterium implicated in the formation of dental caries and, both directly and indirectly, has been associated with severe conditions such as multiple sclerosis, cerebrovascular and peripheral ar... Read More about Polymers for binding of the gram-positive oral pathogen Streptococcus mutans.