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All Outputs (40)

Live quantitative monitoring of mineral deposition in stem cells using tetracycline hydrochloride (2018)
Journal Article
Macri-Pellizzeri, L., De Melo, N., Ahmed, I., Grant, D. M., Scammell, B., & Sottile, V. (2018). Live quantitative monitoring of mineral deposition in stem cells using tetracycline hydrochloride. Tissue Engineering Part C Methods, 24(3), https://doi.org/10.1089/ten.TEC.2017.0400

The final stage of in vitro osteogenic differentiation is characterized by the production of mineral deposits containing calcium cations and inorganic phosphates, which populate the extracellular matrix surrounding the cell monolayer. Conventional hi... Read More about Live quantitative monitoring of mineral deposition in stem cells using tetracycline hydrochloride.

Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomised controlled trial (2018)
Journal Article
das Nair, R., Mhizha-Murira, J. R., Anderson, P., Carpenter, H., Clarke, S., Groves, S., …Lincoln, N. B. (2018). Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomised controlled trial. Clinical Rehabilitation, 32(6), 777-789. https://doi.org/10.1177/0269215518755426

Objective: To determine the feasibility of conducting a trial of a pre-surgical psychological intervention on pain, function, and mood in people with knee osteoarthritis listed for total knee arthroplasty. Design: Multi-centre, mixed-methods feasibi... Read More about Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomised controlled trial.

Development and validation of self-reported line drawings of the modified Beighton score for the assessment of generalised joint hypermobility (2018)
Journal Article
Cooper, D. J., Scammell, B. E., Batt, M. E., & Palmer, D. (in press). Development and validation of self-reported line drawings of the modified Beighton score for the assessment of generalised joint hypermobility. BMC Medical Research Methodology, 18(1), https://doi.org/10.1186/s12874-017-0464-8

Background: The impracticalities and comparative expense of carrying out a clinical assessment is an obstacle in many large epidemiological studies. The purpose of this study was to develop and validate a series of electronic self-reported line drawi... Read More about Development and validation of self-reported line drawings of the modified Beighton score for the assessment of generalised joint hypermobility.

Principles of bone and joint injuries and their healing (2017)
Journal Article
Nyary, T., & Scammell, B. E. (2018). Principles of bone and joint injuries and their healing. Surgery (Oxford), 36(1), https://doi.org/10.1016/j.mpsur.2017.10.005

This article describes the mechanisms of fracture healing (direct and indirect), general fracture management, the influence of the surgeon on the biology and biomechanical environment of bone healing, the management of articular fractures, and disord... Read More about Principles of bone and joint injuries and their healing.

Prevalence of knee pain, radiographic osteoarthritis and arthroplasty in retired professional footballers compared to men in the general population: a cross-sectional study (2017)
Journal Article
Fernandes, G. S., Parekh, S. M., Moses, J., Fuller, C., Scammell, B. E., Batt, M. E., …Doherty, M. (2017). Prevalence of knee pain, radiographic osteoarthritis and arthroplasty in retired professional footballers compared to men in the general population: a cross-sectional study. British Journal of Sports Medicine, https://doi.org/10.1136/bjsports-2017-097503

Objectives: To determine the prevalence of knee pain, radiographic knee osteoarthritis (RKOA), total knee replacement (TKR) and associated risk factors in male ex-professional footballers compared to men in the general population (comparison group).... Read More about Prevalence of knee pain, radiographic osteoarthritis and arthroplasty in retired professional footballers compared to men in the general population: a cross-sectional study.

A systematic review of Vancouver B2 and B3 periprosthetic femoral fractures (2017)
Journal Article
Khan, T., Grindlay, D. J., Scammell, B. E., Ollivere, B., Manktelow, A., & Pearson, R. G. (2017). A systematic review of Vancouver B2 and B3 periprosthetic femoral fractures. Bone and Joint Journal, 99-B(4_Supple_B), 17-25. https://doi.org/10.1302/0301-620X.99B4.BJJ-2016-1311.R1

Aims The aim of this study was to investigate the outcomes of Vancouver type B2 and B3 fractures by performing a systematic review of the methods of surgical treatment which have been reported. Materials and Methods A systematic search was perform... Read More about A systematic review of Vancouver B2 and B3 periprosthetic femoral fractures.

Recovery, responsiveness and interpretability of patient-reported outcome measures after surgery for Dupuytren’s disease (2016)
Journal Article
Rodrigues, J., Zhang, W., Scammell, B. E., Davidson, D., Fullilove, S., Chakrabarti, I., …Davies, T. (2016). Recovery, responsiveness and interpretability of patient-reported outcome measures after surgery for Dupuytren’s disease. Journal of Hand Surgery (European Volume), 42(3), https://doi.org/10.1177/1753193416677712

This prospective cohort study investigated the responsiveness and interpretability of the Disabilities of the Arm, Shoulder and Hand (DASH) and Unité Rhumatologique des Affections de la Main (URAM) outcome measures for assessing recovery after fascie... Read More about Recovery, responsiveness and interpretability of patient-reported outcome measures after surgery for Dupuytren’s disease.

Targeting the D-series resolvin receptor system for the treatment of osteoarthritic pain (2016)
Journal Article
Huang, J., Burston, J. J., Li, L., Ashraf, S., Mapp, P. I., Bennett, A. J., …Chapman, V. (2017). Targeting the D-series resolvin receptor system for the treatment of osteoarthritic pain. Arthritis and Rheumatology, 69(5), 996-1008. https://doi.org/10.1002/art.40001

Objective: Pain is a major symptom of osteoarthritis (OA); current analgesics either do not offer adequate pain relief or are associated with serious side effects. Herein we have investigated the therapeutic potential of targeting the resolvin recept... Read More about Targeting the D-series resolvin receptor system for the treatment of osteoarthritic pain.

Do smokers have greater risk of delayed and non-union after fracture, osteotomy and arthrodesis?: a systematic review with meta-analysis (2016)
Journal Article
Pearson, R. G., Clement, R., Edwards, K., & Scammell, B. E. (2016). Do smokers have greater risk of delayed and non-union after fracture, osteotomy and arthrodesis?: a systematic review with meta-analysis. BMJ Open, 6(11), Article e010303. https://doi.org/10.1136/bmjopen-2015-010303

Objectives: Systematic review and meta-analysis of published observational cohort studies. To quantify the increased risk smokers have of experiencing a delayed and/or non-union in fractures, spinal fusion, osteotomy, arthrodesis or established non-u... Read More about Do smokers have greater risk of delayed and non-union after fracture, osteotomy and arthrodesis?: a systematic review with meta-analysis.

Histopathological subgroups in knee osteoarthritis (2016)
Journal Article
Wyatt, L., Morerton, B., Mapp, P. I., Wilson, D., Hill, R., Ferguson, E., …Walsh, D. A. (in press). Histopathological subgroups in knee osteoarthritis. Osteoarthritis and Cartilage, 25(1), https://doi.org/10.1016/j.joca.2016.09.021

Objective: Osteoarthritis (OA) is a heterogeneous, multi-tissue disease. We hypothesised that different histopathological features characterise different stages during knee OA progression, and that discrete subgroups can be defined based on validated... Read More about Histopathological subgroups in knee osteoarthritis.

Resection and Resolution of Bone Marrow Lesions Associated with an Improvement of Pain after Total Knee Replacement: A Novel Case Study Using a 3-Tesla Metal Artefact Reduction MRI Sequence (2016)
Journal Article
Kurien, T., Kerslake, R., Haywood, B., Pearson, R. G., & Scammell, B. E. (2016). Resection and Resolution of Bone Marrow Lesions Associated with an Improvement of Pain after Total Knee Replacement: A Novel Case Study Using a 3-Tesla Metal Artefact Reduction MRI Sequence. Case Reports in Orthopedics, 2016, 1-5. https://doi.org/10.1155/2016/6043497

We present our case report using a novel metal artefact reduction magnetic resonance imaging (MRI) sequence to observe resolution of subchondral bone marrow lesions (BMLs), which are strongly associated with pain, in a patient after total knee replac... Read More about Resection and Resolution of Bone Marrow Lesions Associated with an Improvement of Pain after Total Knee Replacement: A Novel Case Study Using a 3-Tesla Metal Artefact Reduction MRI Sequence.

Functional outcome and complications following surgery for Dupuytren’s disease: a multi-centre cross-sectional study (2016)
Journal Article
Rodrigues, J., Zhang, W., Scammell, B. E., Chakrabarti, I., Russell, P., Fulllilove, S., …Davis, T. (in press). Functional outcome and complications following surgery for Dupuytren’s disease: a multi-centre cross-sectional study. Journal of Hand Surgery (European Volume), https://doi.org/10.1177/1753193416660045

Variables associated with recurrent Dupuytren’s disease, or a ‘diathesis’, have been investigated, but those associated with functional outcome and complications are less well studied. Outcomes 1 or 5 years after an aponeurotomy, fasciectomy or derm... Read More about Functional outcome and complications following surgery for Dupuytren’s disease: a multi-centre cross-sectional study.

Home-administered pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): study protocol for a randomised controlled trial (2016)
Journal Article
das Nair, R., Anderson, P., Clarke, S. P., Leighton, P., Lincoln, N., Mhizha-Murira, J. R., …Walsh, D. A. (2016). Home-administered pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): study protocol for a randomised controlled trial. Trials, 17(54), 1-11. https://doi.org/10.1186/s13063-016-1165-z

Background: Knee replacement surgery reduces pain for many people with osteoarthritis (OA). However, surgical outcomes are partly dependent on patients’ moods, and those with depression or anxiety have worse outcomes. Approximately one-third of peopl... Read More about Home-administered pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): study protocol for a randomised controlled trial.

Validity of the disabilities of the Arm, Shoulder and Hand patient-reported outcome measure (DASH) and the Quickdash when used in Dupuytren’s disease (2015)
Journal Article
Rodrigues, J., Zhang, W., Scammell, B. E., Russell, P., Chakrabarti, I., Fullilove, S., …Davis, T. (2016). Validity of the disabilities of the Arm, Shoulder and Hand patient-reported outcome measure (DASH) and the Quickdash when used in Dupuytren’s disease. Journal of Hand Surgery (European Volume), 41(6), https://doi.org/10.1177/1753193415601350

This study investigated aspects of the validity and reliability of the 30-item Disabilities of the Arm, Shoulder and Hand patient-reported outcome measure (DASH) and its relationship with the shorter 11-item QuickDASH in patients with Dupuytren’s dis... Read More about Validity of the disabilities of the Arm, Shoulder and Hand patient-reported outcome measure (DASH) and the Quickdash when used in Dupuytren’s disease.

Structural Associations of Symptomatic Knee Osteoarthritis: Structural Associations of Symptomatic Knee OA (2014)
Journal Article
Stoppiello, L. A., Mapp, P. I., Wilson, D., Hill, R., Scammell, B. E., & Walsh, D. A. (2014). Structural Associations of Symptomatic Knee Osteoarthritis: Structural Associations of Symptomatic Knee OA. Arthritis and Rheumatology, 66(11), 3018-3027. https://doi.org/10.1002/art.38778

Objective Structural changes of osteoarthritis (OA) may occur in the absence of pain. In this study, we aimed to identify histopathologic features that are associated with symptomatic knee OA. Methods Medial tibial plateaus and synovium samp... Read More about Structural Associations of Symptomatic Knee Osteoarthritis: Structural Associations of Symptomatic Knee OA.

A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis in a contaminated in vivo bone defect model (2014)
Journal Article
McLaren, J. S., White, L., Cox, H., Ashraf, W., Rahman, C., Blunn, G., …Scammell, B. E. (2014). A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis in a contaminated in vivo bone defect model. eCells and Materials Journal, 27, 332-349. https://doi.org/10.22203/eCM.v027a24

Open fractures are at risk of serious infection and, if infected, require several surgical interventions and courses of systemic antibiotics. We investigated a new injectable formulation that simultaneously hardens in vivo to form a porous scaffold f... Read More about A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis in a contaminated in vivo bone defect model.

A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis and encourage new bone growth (2014)
Journal Article
McLaren, J. S., Bayston, R., White, L. J., Cox, H. C., Ashraf, W., Rahman, C. V., …Scammell, B. E. (2014). A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis and encourage new bone growth. eCells and Materials Journal, 27, 332-349. https://doi.org/10.22203/eCM.v027a24

Open fractures are at risk of serious infection and, if infected, require several surgical interventions and courses of systemic antibiotics. We investigated a new injectable formulation that simultaneously hardens in vivo to form a porous scaffold f... Read More about A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis and encourage new bone growth.

Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain (2010)
Journal Article
Sagar, D. R., Staniaszek, L. E., Okine, B. N., Woodhams, S., Norris, L. M., Pearson, R. G., …Chapman, V. (2010). Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain. Arthritis and Rheumatism, 62(12), https://doi.org/10.1002/art.27698

Objective. To investigate the impact of an experimental model of osteoarthritis (OA) on spinal nociceptive processing and the role of the inhibitory endocannabinoid system in regulating sensory processing at the spinal level. Methods. Experiment... Read More about Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain.