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Chronic postoperative pain after total knee arthroplasty: The potential contributions of synovitis, pain sensitization and pain catastrophizing—An explorative study (2022)
Journal Article
Kurien, T., Kerslake, R. W., Graven‐Nielsen, T., Arendt‐Nielsen, L., Auer, D. P., Edwards, K., …Petersen, K. K. (2022). Chronic postoperative pain after total knee arthroplasty: The potential contributions of synovitis, pain sensitization and pain catastrophizing—An explorative study. European Journal of Pain, 26(9), 1979-1989. https://doi.org/10.1002/ejp.2018

Background: A subset of osteoarthritis patients will experience chronic postoperative pain after total knee arthroplasty (TKA), but the source of pain is unclear. The aim of this exploratory study was to assess patients with and without postoperative... Read More about Chronic postoperative pain after total knee arthroplasty: The potential contributions of synovitis, pain sensitization and pain catastrophizing—An explorative study.

Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model (2021)
Journal Article
Markides, H., Foster, N. C., McLaren, J. S., Hopkins, T., Black, C., Oreffo, R. O. C., …El Haj, A. J. (2021). Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model. Cells, 10(7), Article 1776. https://doi.org/10.3390/cells10071776

The ovine critical-sized defect model provides a robust preclinical model for testing tissue-engineered constructs for use in the treatment of non-union bone fractures and severe trauma. A critical question in cell-based therapies is understanding th... Read More about Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model.

Incidence and risk factors for poor ankle functional recovery, and the development and progression of posttraumatic ankle osteoarthritis after significant ankle ligament injury (SALI): the SALI cohort study protocol (2021)
Journal Article
Bestwick-Stevenson, T., Wyatt, L. A., Palmer, D., Ching, A., Kerslake, R., Coffey, F., …Scammell, B. E. (2021). Incidence and risk factors for poor ankle functional recovery, and the development and progression of posttraumatic ankle osteoarthritis after significant ankle ligament injury (SALI): the SALI cohort study protocol. BMC Musculoskeletal Disorders, 22(1), Article 362. https://doi.org/10.1186/s12891-021-04230-8

Background: Ankle sprains are one of the most common musculoskeletal injuries, accounting for up to 5% of all Emergency Department visits in the United Kingdom. Ankle injury may be associated with future ankle osteoarthritis. Up to 70% of ankle osteo... Read More about Incidence and risk factors for poor ankle functional recovery, and the development and progression of posttraumatic ankle osteoarthritis after significant ankle ligament injury (SALI): the SALI cohort study protocol.

Patient Perspectives on Use of Stem Cells to Treat Osteoporosis (2020)
Journal Article
Brown, H. I., Clutton-Brock, T., Walker, D., Sahota, O., Scammell, B. E., & Ahmed, I. (2020). Patient Perspectives on Use of Stem Cells to Treat Osteoporosis. Journal of Regenerative Medicine & Biology Research, 1(1), 1-20

Osteoporosis is a systemic skeletal disease leading to increased risk of fragility fractures. These fractures lead to significant patient morbidity, increased mortality and substantial health and social care costs. The use of stem cells for cell-base... Read More about Patient Perspectives on Use of Stem Cells to Treat Osteoporosis.

Intra-articular Injection Administration in UK Ex-professional Footballers During Their Playing Careers and the Association with Post-career Knee Osteoarthritis (2020)
Journal Article
Fernandes, G. S., Parekh, S. M., Moses, J. P., Fuller, C. W., Scammell, B. E., Batt, M. E., …Doherty, M. (2020). Intra-articular Injection Administration in UK Ex-professional Footballers During Their Playing Careers and the Association with Post-career Knee Osteoarthritis. Sports Medicine, 50, 1039–1046. https://doi.org/10.1007/s40279-019-01255-x

© 2020, The Author(s). Background: The long-term risk from knee intra-articular (KIA) injections in professional athletes such as ex-footballers remains unknown. The use of KIA injections is controversial and remains anecdotally prolific as it is per... Read More about Intra-articular Injection Administration in UK Ex-professional Footballers During Their Playing Careers and the Association with Post-career Knee Osteoarthritis.

Formulating injectable pastes of porous calcium phosphate glass microspheres for bone regeneration applications (2019)
Journal Article
Matamoros-Veloza, A., Hossain, K. M. Z., Scammell, B. E., Ahmed, I., Hall, R., & Kapur, N. (2020). Formulating injectable pastes of porous calcium phosphate glass microspheres for bone regeneration applications. Journal of the Mechanical Behavior of Biomedical Materials, 102, Article 103489. https://doi.org/10.1016/j.jmbbm.2019.103489

Current trends in regenerative medicine treatments for bone repair applications focus on cell-based therapies. These aim to deliver the treatment via a minimally invasive injection to reduce patient trauma and to improve efficacy. This paper describe... Read More about Formulating injectable pastes of porous calcium phosphate glass microspheres for bone regeneration applications.

Depressive symptoms and the general health of retired professional footballers compared with the general population in the UK: a case–control study (2019)
Journal Article
Fernandes, G. S., Parekh, S. M., Moses, J., Fuller, C. W., Scammell, B., Batt, M. E., …Doherty, M. (2019). Depressive symptoms and the general health of retired professional footballers compared with the general population in the UK: a case–control study. BMJ Open, 9(9), Article e030056. https://doi.org/10.1136/bmjopen-2019-030056

Do antibiotic impregnated calcium sulphate beads improve the healing of neuropathic foot ulcers with osteomyelitis undergoing surgical debridement? (2019)
Journal Article
Dekker, A., Uzoho, C., & Scammell, B. (2019). Do antibiotic impregnated calcium sulphate beads improve the healing of neuropathic foot ulcers with osteomyelitis undergoing surgical debridement?. Wounds, 31(6), 145–150

Background: Neuropathic foot ulcers are common and difficult to treat. Calcium sulphate has been used for antibiotic delivery with success in treating osteomyelitis. Recent case series suggest success in treating osteomyelitis of the foot with a mean... Read More about Do antibiotic impregnated calcium sulphate beads improve the healing of neuropathic foot ulcers with osteomyelitis undergoing surgical debridement?.

Porous phosphate-based glass microspheres show biocompatibility, tissue infiltration and osteogenic onset in an ovine bone defect model (2019)
Journal Article
McLaren, J. S., Macri-Pellizzeri, L., Zakir Hossain, K. M., Patel, U., Grant, D. M., Scammell, B. E., …Sottile, V. (2019). Porous phosphate-based glass microspheres show biocompatibility, tissue infiltration and osteogenic onset in an ovine bone defect model. ACS Applied Materials and Interfaces, 11(17), 15436–15446. https://doi.org/10.1021/acsami.9b04603

Phosphate-based glasses (PBG) are bioactive and fully degradable materials with tailorable degradation rates. PBGs can be produced as porous microspheres through a single-step process, using changes in their formulation and geometry to produce varyin... Read More about Porous phosphate-based glass microspheres show biocompatibility, tissue infiltration and osteogenic onset in an ovine bone defect model.

Risk Factors for Knee Osteoarthritis in Retired Professional Footballers: A Cross-Sectional Study (2019)
Journal Article
Parekh, S. M., Fernandes, G. S., Moses, J. P., Fuller, C. W., Scammell, B. E., Batt, M. E., …Doherty, M. (2021). Risk Factors for Knee Osteoarthritis in Retired Professional Footballers: A Cross-Sectional Study. Clinical Journal of Sport Medicine, 31(3), 281-288. https://doi.org/10.1097/JSM.0000000000000742

Objective: To determine risk factors for three knee osteoarthritis (KOA) outcomes, knee pain (KP), radiographic KOA (RKOA) and total knee replacement (TKR), in professional footballers. Design: This was a cross-sectional study involving a postal que... Read More about Risk Factors for Knee Osteoarthritis in Retired Professional Footballers: A Cross-Sectional Study.

In vitro cellular testing of Strontium/Calcium substituted phosphate glass discs and microspheres shows potential for bone regeneration (2019)
Journal Article
Patel, U., Macri-Pellizzeri, L., Hossain, K. M. Z., Scammell, B. E., Grant, D. M., Scotchford, C. A., …Sottile, V. (2019). In vitro cellular testing of Strontium/Calcium substituted phosphate glass discs and microspheres shows potential for bone regeneration. Journal of Tissue Engineering and Regenerative Medicine, 13(3), 396-405. https://doi.org/10.1002/term.2796

Phosphate glasses (PBG) are ideal materials for regenerative medicine strategies since their composition, degradation rates and ion release profiles can easily be controlled. Strontium has previously been found to simultaneously affect bone resorptio... Read More about In vitro cellular testing of Strontium/Calcium substituted phosphate glass discs and microspheres shows potential for bone regeneration.

Molecular expression patterns in the synovium and their association with advanced symptomatic knee osteoarthritis (2018)
Journal Article
Wyatt, L. A., Nwosu, L. N., Wilson, D., Hill, R., Spendlove, I., Bennett, A. J., …Walsh, D. A. (2018). Molecular expression patterns in the synovium and their association with advanced symptomatic knee osteoarthritis. Osteoarthritis and Cartilage, 27(4), 667-675. https://doi.org/10.1016/j.joca.2018.12.012

Objective: Osteoarthritis (OA) is a major source of knee pain. Mechanisms of OA knee pain are incompletely understood but include synovial pathology. We aimed to identify molecular expression patterns in the synovium associated with symptomatic knee... Read More about Molecular expression patterns in the synovium and their association with advanced symptomatic knee osteoarthritis.

Comparison of different human tissue processing methods for maximization of bacterial recovery (2018)
Journal Article
Askar, M., Ashraf, W., Scammell, B., & Bayston, R. (2019). Comparison of different human tissue processing methods for maximization of bacterial recovery. European Journal of Clinical Microbiology and Infectious Diseases, 38(1), 149-155. https://doi.org/10.1007/s10096-018-3406-4

Tissues are valuable microbiological samples that have proved superiority over swabs. Culture of tissue samples is used in the diagnosis of a variety of infections. However, as well as factors such as the site of obtaining the sample, the number of s... Read More about Comparison of different human tissue processing methods for maximization of bacterial recovery.

Preoperative neuropathic pain like symptoms and central pain mechanisms in knee osteoarthritis predicts poor outcome 6 months after total knee replacement surgery (2018)
Journal Article
Kurien, T., Arendt-Nielsen, L., Petersen, K. K., Graven-Nielsen, T., & Scammell, B. E. (2018). Preoperative neuropathic pain like symptoms and central pain mechanisms in knee osteoarthritis predicts poor outcome 6 months after total knee replacement surgery. Journal of Pain, doi:10.1016/j.jpain.2018.05.011. ISSN 1526-5900

Preoperative pain characteristics in osteoarthritis (OA) patients may explain persistent pain after total knee replacement (TKR). Fifty patients awaiting TKR and 22 asymptomatic controls were recruited to evaluate the degree of neuropathic pain sympt... Read More about Preoperative neuropathic pain like symptoms and central pain mechanisms in knee osteoarthritis predicts poor outcome 6 months after total knee replacement surgery.

Alpha-defensin and the Synovasure lateral flow device for the diagnosis of prosthetic joint infection: a systematic review and meta-analysis (2018)
Journal Article
Marson, B. A., Deshmukh, S. R., Grindlay, D. J. C., & Scammell, B. E. (2018). Alpha-defensin and the Synovasure lateral flow device for the diagnosis of prosthetic joint infection: a systematic review and meta-analysis. Bone and Joint Journal, 100-B(6), 703-711. https://doi.org/10.1302/0301-620x.100b6.bjj-2017-1563.r1

Aims The aim of this review is to evaluate the available literature and to calculate a pooled diagnostic sensitivity and specificity for the different alpha-defensin test systems to diagnose peri-prosthetic infection. Materials and Methods Studi... Read More about Alpha-defensin and the Synovasure lateral flow device for the diagnosis of prosthetic joint infection: a systematic review and meta-analysis.

Early motion and directed exercise (EMADE) versus usual care post ankle fracture fixation: study protocol for a pragmatic randomised controlled trial (2018)
Journal Article
Matthews, P. A., Scammell, B. E., Ali, A., Coughlin, T., Nightingale, J., Khan, T., & Ollivere, B. J. (in press). Early motion and directed exercise (EMADE) versus usual care post ankle fracture fixation: study protocol for a pragmatic randomised controlled trial. Trials, 19(1), https://doi.org/10.1186/s13063-018-2691-7

Background: Following surgical fixation of ankle fractures, the traditional management has included immobilisation for 6 weeks in a below-knee cast. However, this can lead to disuse atrophy of the affected leg and joint stiffness. While early rehabil... Read More about Early motion and directed exercise (EMADE) versus usual care post ankle fracture fixation: study protocol for a pragmatic randomised controlled trial.

Factors associated with pain and osteoarthritis at the hip and knee in Great Britain's Olympians: a cross sectional study (2018)
Journal Article
Cooper, D. J., Scammell, B. E., Batt, M. E., & Palmer, D. (2018). Factors associated with pain and osteoarthritis at the hip and knee in Great Britain's Olympians: a cross sectional study. British Journal of Sports Medicine, 52(17), 1101-1108. https://doi.org/10.1136/bjsports-2017-098315

Background: Knowledge of the epidemiology and potentially modifiable factors associated with musculoskeletal disease is an important first step in injury prevention among elite athletes. Aim: This study investigated the prevalence and factors asso... Read More about Factors associated with pain and osteoarthritis at the hip and knee in Great Britain's Olympians: a cross sectional study.

Translation of remote control regenerative technologies for bone repair (2018)
Journal Article
Markides, H., McLaren, J. S., Telling, N. D., Alom, N., Al-Mutheffer, E. A., Oreffo, R., …El-Haj, A. (2018). Translation of remote control regenerative technologies for bone repair. npj Regenerative Medicine, 3(9), 1-12. https://doi.org/10.1038/s41536-018-0048-1

The role of biomechanical stimuli, or mechanotransduction, in normal bone homeostasis and repair is understood to facilitate effective osteogenesis of mesenchymal stem cells (MSCs) in vitro. Mechanotransduction has been integrated into a multitude of... Read More about Translation of remote control regenerative technologies for bone repair.

Porous calcium phosphate glass microspheres for orthobiologic applications (2018)
Journal Article
Hossain, K. M. Z., Patel, U., Kennedy, A. R., Macri-Pellizzeri, L., Sottile, V., Grant, D. M., …Ahmed, I. (2018). Porous calcium phosphate glass microspheres for orthobiologic applications. Acta Biomaterialia, 72, 396-406. https://doi.org/10.1016/j.actbio.2018.03.040

© 2018 Orthobiologics is a rapidly advancing field utilising cell-based therapies and biomaterials to enable the body to repair and regenerate musculoskeletal tissues. This paper reports on a cost-effective flame spheroidisation process for producti... Read More about Porous calcium phosphate glass microspheres for orthobiologic applications.