Research Repository

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A theoretical model of inflammation- and mechanotransduction- driven asthmatic airway remodelling (2018)
Journal Article
Hill, M., Philp, C. J., Billington, C. K., Tatler, A. L., Johnson, S. R., O'Dea, R. D., & Brook, B. S. (in press). A theoretical model of inflammation- and mechanotransduction- driven asthmatic airway remodelling. Biomechanics and Modeling in Mechanobiology, doi:10.1007/s10237-018-1037-4. ISSN 1617-7959

Inflammation, airway hyper-responsiveness and airway remodelling are well-established hallmarks of asthma, but their inter-relationships remain elusive. In order to obtain a better understanding of their inter-dependence, we develop a mechanochemical... Read More

Effect of loading history on airway smooth muscle cell-matrix adhesions (2018)
Journal Article
Irons, L., Owen, M. R., O'Dea, R. D., & Brook, B. S. (2018). Effect of loading history on airway smooth muscle cell-matrix adhesions. Biophysical Journal, 114(11), (2679-2690). doi:10.1016/j.bpj.2018.04.026. ISSN 0006-3495

Integrin-mediated adhesions between airway smooth muscle (ASM) cells and the extracellular matrix (ECM) regulate how contractile forces generated within the cell are transmitted to its external environment. Environmental cues are known to influence t... Read More

A multiphase multiscale model for nutrient limited tissue growth (2018)
Journal Article
Holden, E., Collis, J., Brook, B. S., & O'Dea, R. D. (2018). A multiphase multiscale model for nutrient limited tissue growth. ANZIAM Journal, 59(4), doi:10.1017/S1446181118000044. ISSN 1446-1811

In this work, an effective macroscale description is derived for the growth of tissue on a porous scaffold. A multiphase model is employed to describe the tissue dynamics; linearisation to facilitate a multiple-scale homogenisation provides an effect... Read More

Mathematical modelling of cytokines, MMPs andfibronectin fragments in osteoarthritic cartilage (2017)
Journal Article
Baker, M., Brook, B. S., & Owen, M. R. (2017). Mathematical modelling of cytokines, MMPs andfibronectin fragments in osteoarthritic cartilage. Journal of Mathematical Biology, doi:10.1007/s00285-017-1104-y

Osteoarthritis (OA) is a degenerative disease which causes pain and stiffness in joints. OA progresses through excessive degradation of joint cartilage, eventually leading to significant joint degeneration and loss of function. Cytokines, a group of... Read More

Airway and parenchymal strains during bronchoconstriction in the precision cut lung slice (2016)
Journal Article
Hiorns, J. E., Bidan, C. M., Jensen, O. E., Gosens, R., Kistemaker, L. E., Fredberg, J. J., …Brook, B. S. (2016). Airway and parenchymal strains during bronchoconstriction in the precision cut lung slice. Frontiers in Physiology, 7, doi:10.3389/fphys.2016.00309. ISSN 1664-042X

The precision-cut lung slice (PCLS) is a powerful tool for studying airway reactivity, but biomechanical measurements to date have largely focused on changes in airway caliber. Here we describe an image processing tool that reveals the associated spa... Read More

Static and dynamic stress heterogeneity in a multiscale model of the asthmatic airway wall (2016)
Journal Article
Hiorns, J. E., Jensen, O. E., & Brook, B. S. (2016). Static and dynamic stress heterogeneity in a multiscale model of the asthmatic airway wall. Journal of Applied Physiology, 121(1), doi:10.1152/japplphysiol.00715.2015. ISSN 8750-7587

Airway hyperresponsiveness (AHR) is a key characteristic of asthma that remains poorly understood. Tidal breathing and deep inspiration ordinarily cause rapid relaxation of airway smooth muscle (ASM) (as demonstrated via application of length fluctua... Read More

Activation of store-operated calcium entry in airway smooth muscle cells: insight from a mathematical model (2013)
Journal Article
smooth muscle cells: insight from a mathematical model. PLoS ONE, 8(7), doi:10.1371/journal.pone.0069598. ISSN 1932-6203

Intracellular dynamics of airway smooth muscle cells (ASMC) mediate ASMC contraction and proliferation, and thus play a key role in airway hyper-responsiveness (AHR) and remodelling in asthma. We evaluate the importance of store-operated entry (SOC... Read More