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Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study (2018)
Journal Article
Shrine, N., Portelli, M. A., John, C., Soler Artigas, M., Bennett, N., Hall, R., …Sayers, I. (2018). Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study. Lancet Respiratory Medicine, 7(1), 20-34. doi:10.1016/S2213-2600(18)30389-8

Background Few genetic studies that focus on moderate-to-severe asthma exist. We aimed to identity novel genetic variants associated with moderate-to-severe asthma, see whether previously identified genetic variants for all types of asthma contribut... Read More

Expression of a SOX1 overlapping transcript in neural differentiation and cancer models (2017)
Journal Article
Azaz, A., Strohbuecker, S., Tufarelli, C., & Sottile, V. (2017). Expression of a SOX1 overlapping transcript in neural differentiation and cancer models. Cellular and Molecular Life Sciences, 74(22),

SOX1 is a member of the SOXB1 subgroup of transcription factors involved in early embryogenesis, CNS development and maintenance of neural stem cells. The structure and regulation of the human SOX1 locus has been less studied than that of SOX2, anoth... Read More

Anti-nociceptive and desensitizing effects of olvanil on capsaicin-induced thermal hyperalgesia in the rat (2016)
Journal Article
Alsalem, M., Millns, P., Altarifi, A., El-Salem, K., Chapman, V., & Kendall, D. A. (in press). Anti-nociceptive and desensitizing effects of olvanil on capsaicin-induced thermal hyperalgesia in the rat. BMC Pharmacology and Toxicology, 17, doi:10.1186/s40360-016-0074-9. ISSN 2050-6511

Background: Olvanil (NE 19550) is a non-pungent synthetic analogue of capsaicin, the natural pungent ingredient of capsicum which activates the transient receptor potential vanilloid type-1 (TRPV1) channel and was developed as a potential analgesic c... Read More