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Do Asian patients require only half of the clozapine dose prescribed for Caucasians? A critical overview (2020)
Journal Article
de Leon, J., Rajkumar, A. P., Kaithi, A. R., Schoretsanitis, G., Kane, J. M., Wang, C., …Andrade, C. (2020). Do Asian patients require only half of the clozapine dose prescribed for Caucasians? A critical overview. Indian Journal of Psychological Medicine, 42(1), 4-10. https://doi.org/10.4103/IJPSYM.IJPSYM_379_19

Since 1997, studies have found that Asians need lower clozapine doses than Caucasians. Caucasians with average clozapine metabolism may need from 300 to 600 mg/day to reach the therapeutic range (350 ng/ml). Thus, serum clozapine concentration-to-dos... Read More about Do Asian patients require only half of the clozapine dose prescribed for Caucasians? A critical overview.

Exploring the prevalence of clozapine phenotypic poor metabolizers in 4 Asian samples: they ranged between 2 and 13% (2019)
Journal Article
Ruan, C., Wang, C., Tang, Y., Lin, S., Lee, S., Hong, K. S., …De Leon, J. (in press). Exploring the prevalence of clozapine phenotypic poor metabolizers in 4 Asian samples: they ranged between 2 and 13%. Journal of Clinical Psychopharmacology,

Purpose/Background: Clozapine clearance is influenced by sex, smoking status, ethnicity, co-prescription of inducers or inhibitors, obesity and inflammation. In 126 Beijing inpatients, we measured repeated trough steady-state serum concentrations and... Read More about Exploring the prevalence of clozapine phenotypic poor metabolizers in 4 Asian samples: they ranged between 2 and 13%.

Systematic review of genetic variants associated with cognitive impairment and depressive symptoms in Parkinson’s disease (2019)
Journal Article
D’Souza, T., & Rajkumar, A. P. (2019). Systematic review of genetic variants associated with cognitive impairment and depressive symptoms in Parkinson’s disease. Acta Neuropsychiatrica, 1-13. doi:10.1017/neu.2019.28

Objective: Cognitive impairment and depression are among the most prevalent and most disabling non-motor symptoms in Parkinson’s disease (PD). The genetic factors that are associated with these symptoms remain uncertain. This systematic review aims... Read More about Systematic review of genetic variants associated with cognitive impairment and depressive symptoms in Parkinson’s disease.

Post-mortem cortical transcriptomics of Lewy body dementia reveal mitochondrial dysfunction and lack of neuroinflammation (2019)
Journal Article
Rajkumar, A. P., Bidkhori, G., Shoaie, S., Clarke, E., Morrin, H., Hye, A., …Aarsland, D. (2020). Post-mortem cortical transcriptomics of Lewy body dementia reveal mitochondrial dysfunction and lack of neuroinflammation. American Journal of Geriatric Psychiatry, 28(1), 75-86. https://doi.org/10.1016/j.jagp.2019.06.007

Objectives: Prevalence of Lewy body dementias (LBD) is second only to Alzheimer's disease (AD) among people with neurodegenerative dementia. LBD cause earlier mortality, more intense neuropsychiatric symptoms, more caregivers' burden, and higher cost... Read More about Post-mortem cortical transcriptomics of Lewy body dementia reveal mitochondrial dysfunction and lack of neuroinflammation.

Endogenous and Antipsychotic-Related Risks for Diabetes Mellitus in Young People With Schizophrenia: A Danish Population-Based Cohort Study (2017)
Journal Article
Rajkumar, A. P., Horsdal, H. T., Wimberley, T., Cohen, D., Mors, O., Børglum, A. D., & Gasse, C. (2017). Endogenous and Antipsychotic-Related Risks for Diabetes Mellitus in Young People With Schizophrenia: A Danish Population-Based Cohort Study. American Journal of Psychiatry, 174(7), 686-694. https://doi.org/10.1176/appi.ajp.2016.16040442

Health, Social, and Economic Variables Associated with Depression Among Older People in Low and Middle Income Countries: World Health Organization Study on Global AGEing and Adult Health (2016)
Journal Article
Brinda, E. M., Rajkumar, A. P., Attermann, J., Gerdtham, U. G., Enemark, U., & Jacob, K. S. (2016). Health, Social, and Economic Variables Associated with Depression Among Older People in Low and Middle Income Countries: World Health Organization Study on Global AGEing and Adult Health. American Journal of Geriatric Psychiatry, 24(12), 1196-1208. https://doi.org/10.1016/j.jagp.2016.07.016

Objective Although depression among older people is an important public health problem worldwide, systematic studies evaluating its prevalence and determinants in low and middle income countries (LMICs) are sparse. The biopsychosocial model of dep... Read More about Health, Social, and Economic Variables Associated with Depression Among Older People in Low and Middle Income Countries: World Health Organization Study on Global AGEing and Adult Health.

Apathy and Its Response to Antipsychotic Review and Nonpharmacological Interventions in People With Dementia Living in Nursing Homes: WHELD, a Factorial Cluster Randomized Controlled Trial (2016)
Journal Article
Rajkumar, A. P., Ballard, C., Fossey, J., Corbett, A., Woods, B., Orrell, M., …Testad, I. (2016). Apathy and Its Response to Antipsychotic Review and Nonpharmacological Interventions in People With Dementia Living in Nursing Homes: WHELD, a Factorial Cluster Randomized Controlled Trial. Journal of the American Medical Directors Association, 17(8), 741-747. https://doi.org/10.1016/j.jamda.2016.04.006

Objectives Apathy is common, impactful, and difficult to manage in people with dementia. We evaluated the efficacy of nonpharmacological interventions, exercise, and social interaction, in combination with antipsychotic review, to reduce apathy in p... Read More about Apathy and Its Response to Antipsychotic Review and Nonpharmacological Interventions in People With Dementia Living in Nursing Homes: WHELD, a Factorial Cluster Randomized Controlled Trial.