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Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages (2016)
Journal Article
Piccinini, A. M., Zuliani-Alvarez, L., Lim, J. M., & Midwood, K. S. (2016). Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages. Science Signaling, 9(443), ra86-ra86. https://doi.org/10.1126/scisignal.aaf3596

Macrophages exhibit a phenotypic plasticity that enables them to orchestrate specific immune responses to distinct threats. However, the factors that control macrophage behaviour in a context dependent manner are not well understood. Lipopolysacchari... Read More about Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages.

Interfering with the CCL2–glycosaminoglycan axis as a potential approach to modulate neuroinflammation (2016)
Journal Article
Gschwandtner, M., Piccinini, A. M., Geriza, T., Adage, T., & Kungl, A. (2016). Interfering with the CCL2–glycosaminoglycan axis as a potential approach to modulate neuroinflammation. Neuroscience Letters, 626, doi:10.1016/j.neulet.2016.05.037

Multiple Sclerosis, a chronic inflammatory demyelinating disease of the central nervous system, involves an increased expression of monocyte chemotactic protein 1 MCP1-/CCL2. For exerting its chemotactic effects, chemokine binding to glycosaminoglyca... Read More about Interfering with the CCL2–glycosaminoglycan axis as a potential approach to modulate neuroinflammation.

Investigating the role of toll-like receptors in models of arthritis (2016)
Journal Article
Piccinini, A. M., Williams, L., McCann, F. E., & Midwood, K. S. (2016). Investigating the role of toll-like receptors in models of arthritis. Methods in Molecular Biology, 1390, (351-381). doi:10.1007/978-1-4939-3335-8_22

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation leading to tissue destruction and progressive loss of joint function. Here we describe two methods that can be used to assess the contribution... Read More about Investigating the role of toll-like receptors in models of arthritis.


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