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Consequences of late-stage non-small cell lung cancer cachexia on muscle metabolic processes (2016)
Journal Article
Murton, A. J., Maddocks, M., Stephens, F. B., Marimuthu, K., England, R., & Wilcock, A. (in press). Consequences of late-stage non-small cell lung cancer cachexia on muscle metabolic processes. Clinical Lung Cancer, doi:10.1016/j.cllc.2016.06.003

Introduction: Loss of muscle is common in patients with advanced non-small cell lung cancer (NSCLC), and contributes to the high morbidity and mortality of this group. The exact mechanisms behind the loss of muscle are unclear. Patients and methods... Read More about Consequences of late-stage non-small cell lung cancer cachexia on muscle metabolic processes.

Obesity appears to be associated with altered muscle protein synthetic and breakdown responses to increased nutrient delivery in older men, but not reduced muscle mass or contractile function. (2015)
Journal Article
Murton, A. J., Marimuthu, K., Mallinson, J. E., Selby, A. L., Smith, K., Rennie, M. J., & Greenhaff, P. L. (2015). Obesity appears to be associated with altered muscle protein synthetic and breakdown responses to increased nutrient delivery in older men, but not reduced muscle mass or contractile function. Diabetes, 64(9), doi:10.2337/db15-0021

Obesity is increasing, yet despite the necessity to maintain muscle mass and function with age, the effect of obesity on muscle protein turnover in older adults remains unknown. Eleven obese (BMI 31.9 ±1.1) and 15 healthy weight (HW; BMI 23.4 ±0.3) o... Read More about Obesity appears to be associated with altered muscle protein synthetic and breakdown responses to increased nutrient delivery in older men, but not reduced muscle mass or contractile function..

Statin myalgia is not associated with reduced muscle strength, mass or protein turnover in older male volunteers, but is allied with a slowing of time to peak power output, insulin resistance and differential muscle mRNA expression: Statin myalgia, muscle (2015)
Journal Article
Selby, A., Murton, A., Mallinson, J. E., Marimuthu, K., Murton, A. J., Selby, A. L., …Greenhaff, P. L. (2015). Statin myalgia is not associated with reduced muscle strength, mass or protein turnover in older male volunteers, but is allied with a slowing of time to peak power output, insulin resistance and differential muscle mRNA expression: Statin myalgia, muscle function and metabolism. Journal of Physiology, 593(5), 1239-1257. https://doi.org/10.1113/jphysiol.2014.285577

Statins are associated with muscle myalgia and myopathy, which probably reduce habitual physical activity. This is particularly relevant to older people who are less active, sarcopaenic and at increased risk of statin myalgia. We hypothesised that st... Read More about Statin myalgia is not associated with reduced muscle strength, mass or protein turnover in older male volunteers, but is allied with a slowing of time to peak power output, insulin resistance and differential muscle mRNA expression: Statin myalgia, muscle.

Transient transcriptional events in human skeletal muscle at the outset of concentric resistance exercise training (2014)
Journal Article
Murton, A. J., Billeter, R., Stephens, F. B., Des Etages, S., Graber, F., Hill, R., …Greenhaff, P. L. (2014). Transient transcriptional events in human skeletal muscle at the outset of concentric resistance exercise training. Journal of Applied Physiology, 116(1), doi:10.1152/japplphysiol.00426.2013

We sought to ascertain the time course of transcriptional events that occur in human skeletal muscle at the outset of resistance exercise (RE) training in RE naive individuals and determine whether the magnitude of response was associated with exerci... Read More about Transient transcriptional events in human skeletal muscle at the outset of concentric resistance exercise training.