All Outputs (9)

An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells (2013)
Journal Article
Sharquie, I. K., Al-Ghouleh, A., Fitton, P., Clark, M. R., Armour, K. L., Sewell, H. F., …Ghaemmaghami, A. M. (2013). An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells. BMC Immunology, 14(Decemb), Article 12. https://doi.org/10.1186/1471-2172-14-54

Background: Allergen recognition by dendritic cells (DCs) is a key event in the allergic cascade leading to production of IgE antibodies. C-type lectins, such as the mannose receptor and DC-SIGN, were recently shown to play an important role in the u... Read More about An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells.

Post-processing of polymer foam tissue scaffolds with high power ultrasound: A route to increased pore interconnectivity, pore size and fluid transport (2013)
Journal Article
Watson, N. J., Johal, R. K., Glover, Z., Reinwald, Y., White, L. J., Ghaemmaghami, A. M., …Parker, N. G. (2013). Post-processing of polymer foam tissue scaffolds with high power ultrasound: A route to increased pore interconnectivity, pore size and fluid transport. Materials Science and Engineering: C, 33(8), 4825-4832. https://doi.org/10.1016/j.msec.2013.07.046

The aimof this work is to demonstrate that the structural and fluidic properties of polymer foamtissue scaffolds, post-fabrication but prior to the introduction of cells, can be engineered via exposure to high power ultrasound. Our analysis is suppor... Read More about Post-processing of polymer foam tissue scaffolds with high power ultrasound: A route to increased pore interconnectivity, pore size and fluid transport.

Self-reporting Scaffolds for 3-Dimensional Cell Culture (2013)
Journal Article
Harrington, H., Rose, F. R., Aylott, J. W., & Ghaemmaghami, A. M. (2013). Self-reporting Scaffolds for 3-Dimensional Cell Culture. Journal of Visualized Experiments, https://doi.org/10.3791/50608

Culturing cells in 3D on appropriate scaffolds is thought to better mimic the in vivo microenvironment and increase cell-cell interactions. The resulting 3D cellular construct can often be more relevant to studying the molecular events and cell-cell... Read More about Self-reporting Scaffolds for 3-Dimensional Cell Culture.

Allergen recognition by innate immune cells: critical role of dendritic and epithelial cells (2013)
Journal Article
Salazar, F., & Ghaemmaghami, A. M. (2013). Allergen recognition by innate immune cells: critical role of dendritic and epithelial cells. Frontiers in Immunology, 4, Article 356. https://doi.org/10.3389/fimmu.2013.00356

Allergy is an exacerbated response of the immune system against non-self-proteins called allergens and is typically characterized by biased type-2 T helper cell and deleterious IgE mediated immune responses. The allergic cascade starts with the recog... Read More about Allergen recognition by innate immune cells: critical role of dendritic and epithelial cells.

Interconnectivity and permeability of supercritical fluid-foamed scaffolds and the effect of their structural properties on cell distribution (2013)
Journal Article
Reinwald, Y., Johal, R. K., Ghaemmaghami, A. M., Rose, F. R., Howdle, S. M., & Shakesheff, K. M. (2014). Interconnectivity and permeability of supercritical fluid-foamed scaffolds and the effect of their structural properties on cell distribution. Polymer, 55(1), 435-444. https://doi.org/10.1016/j.polymer.2013.09.041

This study aims to investigate interconnectivity and permeability of scCO2-foamed scaffolds and the influence of structural scaffold properties on cell distribution. Supercritical fluid technology was utilized to fabricated scaffolds from 37 kDa, 53... Read More about Interconnectivity and permeability of supercritical fluid-foamed scaffolds and the effect of their structural properties on cell distribution.

Engineering functional epithelium for regenerative medicine and in vitro organ models: A review (2013)
Journal Article
Vrana, N. E., Lavalle, P., Dokmeci, M. R., Dehghani, F., Ghaemmaghami, A. M., & Khademhosseini, A. (2013). Engineering functional epithelium for regenerative medicine and in vitro organ models: A review. Tissue Engineering Part B: Reviews, 19(6), 529-543. https://doi.org/10.1089/ten.teb.2012.0603

Recent advances in the fields of microfabrication, biomaterials, and tissue engineering have provided new opportunities for developing biomimetic and functional tissues with potential applications in disease modeling, drug discovery, and replacing da... Read More about Engineering functional epithelium for regenerative medicine and in vitro organ models: A review.

The development of a 3D immunocompetent model of human skin (2013)
Journal Article
Chau, D. Y., Johnson, C., MacNeil, S., Haycock, J. W., & Ghaemmaghami, A. M. (2013). The development of a 3D immunocompetent model of human skin. Biofabrication, 5(3), Article 035011. https://doi.org/10.1088/1758-5082/5/3/035011

As the first line of defence, skin is regularly exposed to a variety of biological, physical and chemical insults. Therefore, determining the skin sensitization potential of new chemicals is of paramount importance from the safety assessment and regu... Read More about The development of a 3D immunocompetent model of human skin.

Label-free separation and sorting of human monocytes and T-cells by electrowetting and dielectrophoresis (2013)
Conference Proceeding
Huang, C. Y., Chiang, M. Y., Fan, S. K., Ghaemmaghami, A. M., & Hsu, W. (2013). Label-free separation and sorting of human monocytes and T-cells by electrowetting and dielectrophoresis. In 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (873-876). https://doi.org/10.1109/NEMS.2013.6559863

We report a label-free separation and sorting approach based on electrowetting-on-dielectric (EWOD) and dielectrophoresis (DEP) to manipulate human monocyte (THP-1) and T-cell (Jurkat) lines in droplets without any impact on cell viability. In additi... Read More about Label-free separation and sorting of human monocytes and T-cells by electrowetting and dielectrophoresis.

The role of lectins in allergic sensitization and allergic disease (2013)
Journal Article
Salazar, F., Sewell, H. F., Shakib, F., & Ghaemmaghami, A. M. (2013). The role of lectins in allergic sensitization and allergic disease. Journal of Allergy and Clinical Immunology, 132(1), 27-36. https://doi.org/10.1016/j.jaci.2013.02.001

Allergic diseases are a global public health issue affecting millions of persons around the world. However, full understanding of the molecular basis of this group of chronic inflammatory disorders remains rather elusive. Recently, the role of carboh... Read More about The role of lectins in allergic sensitization and allergic disease.