All Outputs (2)

Gelation properties of self-assembling N-acyl modified cytidine derivatives (2014)
Journal Article
Skilling, K. J., Ndungu, A., Kellam, B., Ashford, M., Bradshaw, T. D., & Marlow, M. (in press). Gelation properties of self-assembling N-acyl modified cytidine derivatives. Journal of Materials Chemistry B, 2(47), https://doi.org/10.1039/C4TB01375A

In this study we report the synthesis of new cytidine derived gelators possessing acyl chains of different lengths. These low molecular weight gelators were shown to form self-supporting gels at 0.5 % (w/v) in binary systems of aqueous miscible polar... Read More about Gelation properties of self-assembling N-acyl modified cytidine derivatives.

Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73 (2014)
Journal Article
Lam, F., Abbas, A. Y., Shao, H., Teo, T., Adams, J., Li, P., …Wang, S. (2014). Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73. Oncotarget, 5(17), 7691–7704. https://doi.org/10.18632/oncotarget.2296

Dysregulation of cellular transcription and translation is a fundamental hallmark of cancer. As CDK9 and Mnks play pivotal roles in the regulation of RNA transcription and protein synthesis, respectively, they are important targets for drug developme... Read More about Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73.