All Outputs (34)

A self‐assembled 3D model demonstrates how stiffness educates tumor cell phenotypes and therapy resistance in pancreatic cancer (2024)
Journal Article
Liu, Y., Okesola, B. O., de la Peña, D. O., Li, W., Lin, M., Trabulo, S. M. D., …Pearce, O. M. (in press). A self‐assembled 3D model demonstrates how stiffness educates tumor cell phenotypes and therapy resistance in pancreatic cancer. Advanced Healthcare Materials, Article 2301941. https://doi.org/10.1002/adhm.202301941

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense and stiff extracellular matrix (ECM) associated with tumor progression and therapy resistance. To further the understanding of how stiffening of the tumor microenvironment (TME) cont... Read More about A self‐assembled 3D model demonstrates how stiffness educates tumor cell phenotypes and therapy resistance in pancreatic cancer.

Co-assembling living material as an in vitro lung epithelial infection model (2023)
Journal Article
Wu, Y., Romero, M., Robertson, S. N., Fenn, S., Fisher, L., Willingham, I., …Mata, A. (2024). Co-assembling living material as an in vitro lung epithelial infection model. Matter, 7(1), 216-236. https://doi.org/10.1016/j.matt.2023.10.029

Biofilms are robust living 3D materials that play key roles in nature but also cause major problems, such as tolerance to antibiotic treatment. Recreation of these living structures in vitro is critical to understand their biology and develop solutio... Read More about Co-assembling living material as an in vitro lung epithelial infection model.

Bioactive and chemically defined hydrogels with tunable stiffness guide cerebral organoid formation and modulate multi-omics plasticity in cerebral organoids (2023)
Journal Article
Isik, M., Okesola, B. O., Eylem, C. C., Kocak, E., Nemutlu, E., D'Este, M., …Derkus, B. (2023). Bioactive and chemically defined hydrogels with tunable stiffness guide cerebral organoid formation and modulate multi-omics plasticity in cerebral organoids. Acta Biomaterialia, 171, 223-238. https://doi.org/10.1016/j.actbio.2023.09.040

Organoids are an emerging technology with great potential in human disease modelling, drug development, diagnosis, tissue engineering, and regenerative medicine. Organoids as 3D-tissue culture systems have gained special attention in the past decades... Read More about Bioactive and chemically defined hydrogels with tunable stiffness guide cerebral organoid formation and modulate multi-omics plasticity in cerebral organoids.

Elastin-like recombinamer-mediated hierarchical mineralization coatings on Zr-16Nb-xTi (x=4,16wt%) alloy surfaces improve biocompatibility (2023)
Journal Article
Xue, R., Deng, X., Xu, X., Tian, Y., Hasan, A., Mata, A., …Liu, L. (2023). Elastin-like recombinamer-mediated hierarchical mineralization coatings on Zr-16Nb-xTi (x=4,16wt%) alloy surfaces improve biocompatibility. Biomaterials Advances, 151, Article 213471. https://doi.org/10.1016/j.bioadv.2023.213471

The biocompatibility of biomedical materials is vital to their applicability and functionality. However, modifying surfaces for enhanced biocompatibility using traditional surface treatment techniques is challenging. We employed a mineralizing elasti... Read More about Elastin-like recombinamer-mediated hierarchical mineralization coatings on Zr-16Nb-xTi (x=4,16wt%) alloy surfaces improve biocompatibility.

Synthetic extracellular matrices with function-encoding peptides (2023)
Journal Article
Ligorio, C., & Mata, A. (2023). Synthetic extracellular matrices with function-encoding peptides. Nature Reviews Bioengineering, 1, 518–536. https://doi.org/10.1038/s44222-023-00055-3

The communication of cells with their surroundings is mostly encoded in the epitopes of structural and signalling proteins present in the extracellular matrix (ECM). These peptide epitopes can be incorporated in biomaterials to serve as function-enco... Read More about Synthetic extracellular matrices with function-encoding peptides.

Biomaterial-based platforms for tumour tissue engineering (2023)
Journal Article
Curvello, R., Kast, V., Ordóñez-Morán, P., Mata, A., & Loessner, D. (2023). Biomaterial-based platforms for tumour tissue engineering. Nature Reviews Materials, 8, 314–330. https://doi.org/10.1038/s41578-023-00535-3

Tissue engineering has produced innovative tools for cancer research. 3D cancer models based on molecularly designed biomaterials aim to harness the dimensionality and biomechanical and biochemical properties of tumour tissues. However, to date, desp... Read More about Biomaterial-based platforms for tumour tissue engineering.

Peptide–Protein Coassemblies into Hierarchical and Bioactive Tubular Membranes (2023)
Journal Article
Majkowska, A., Inostroza-Brito, K. E., Gonzalez, M., Redondo-Gómez, C., Rice, A., Rodriguez-Cabello, J. C., …Mata, A. (2023). Peptide–Protein Coassemblies into Hierarchical and Bioactive Tubular Membranes. Biomacromolecules, 24(10), 4419-4429. https://doi.org/10.1021/acs.biomac.2c01095

Multicomponent self-assembly offers opportunities for the design of complex and functional biomaterials with tunable properties. Here, we demonstrate how minor modifications in the molecular structures of peptide amphiphiles (PAs) and elastin-like re... Read More about Peptide–Protein Coassemblies into Hierarchical and Bioactive Tubular Membranes.

Disinfector-Assisted Low Temperature Reduced Graphene Oxide-Protein Surgical Dressing for the Postoperative Photothermal Treatment of Melanoma (2022)
Journal Article
Wu, Y., Yang, J., van Teijlingen, A., Berardo, A., Corridori, I., Feng, J., …Mata, A. (2022). Disinfector-Assisted Low Temperature Reduced Graphene Oxide-Protein Surgical Dressing for the Postoperative Photothermal Treatment of Melanoma. Advanced Functional Materials, 32(38), Article 2205802. https://doi.org/10.1002/adfm.202205802

Materials that combine the functionalities of both of proteins and graphene are of great interest for the engineering of biosensing, drug delivery, and regenerative devices. Graphene oxide (GO) offers an opportunity to design GO-protein interactions... Read More about Disinfector-Assisted Low Temperature Reduced Graphene Oxide-Protein Surgical Dressing for the Postoperative Photothermal Treatment of Melanoma.

Mineralizing Coating on 3D Printed Scaffolds for the Promotion of Osseointegration (2022)
Journal Article
Hasan, A., Bagnol, R., Owen, R., Latif, A., Rostam, H. M., Elsharkawy, S., …Mata, A. (2022). Mineralizing Coating on 3D Printed Scaffolds for the Promotion of Osseointegration. Frontiers in Bioengineering and Biotechnology, 10, Article 836386. https://doi.org/10.3389/fbioe.2022.836386

Design and fabrication of implants that can perform better than autologous bone grafts remain an unmet challenge for the hard tissue regeneration in craniomaxillofacial applications. Here, we report an integrated approach combining additive manufactu... Read More about Mineralizing Coating on 3D Printed Scaffolds for the Promotion of Osseointegration.

Rational design of hydrogels for immunomodulation (2022)
Journal Article
Bu, W., Wu, Y., Ghaemmaghami, A. M., Sun, H., & Mata, A. (2022). Rational design of hydrogels for immunomodulation. Regenerative Biomaterials, 9, Article rbac009. https://doi.org/10.1093/rb/rbac009

The immune system protects organisms against endogenous and exogenous harm and plays a key role in tissue development, repair and regeneration. Traditional immunomodulatory biologics exhibit limitations including degradation by enzymes, short half-li... Read More about Rational design of hydrogels for immunomodulation.

Embracing complexity in biomaterials design (2022)
Journal Article
Azevedo, H. S., & Mata, A. (2022). Embracing complexity in biomaterials design. Personnel Assessment and Decisions, 6, Article 100039. https://doi.org/10.1016/j.bbiosy.2022.100039

Animate materials, man-made materials behaving like living systems, are attracting enormous interest across a range of sectors, from construction and transport industry to medicine. In this leading opinion article, we propose that embracing complexit... Read More about Embracing complexity in biomaterials design.

Disordered Protein Stabilization by Co-Assembly of Short Peptides Enables Formation of Robust Membranes (2021)
Journal Article
Ghosh, M., Majkowska, A., Mirsa, R., Bera, S., Rodríguez-Cabello, J. C., Mata, A., & Adler-Abramovich, L. (2022). Disordered Protein Stabilization by Co-Assembly of Short Peptides Enables Formation of Robust Membranes. ACS Applied Materials and Interfaces, 14(1), 464-473. https://doi.org/10.1021/acsami.1c22136

Molecular self-assembly is a spontaneous natural process resulting in highly ordered nano to microarchitectures. We report temperature-independent formation of robust stable membranes obtained by the spontaneous interaction of intrinsically disordere... Read More about Disordered Protein Stabilization by Co-Assembly of Short Peptides Enables Formation of Robust Membranes.

Peptide Amphiphile Hydrogels Based on Homoternary Cucurbit[8]uril Host-Guest Complexes (2021)
Journal Article
Redondo-Gómez, C., Padilla-Lopátegui, S., Mata, A., & Azevedo, H. S. (2022). Peptide Amphiphile Hydrogels Based on Homoternary Cucurbit[8]uril Host-Guest Complexes. Bioconjugate Chemistry, 33(1), 111-120. https://doi.org/10.1021/acs.bioconjchem.1c00441

Supramolecular hydrogels based on peptide amphiphiles (PAs) are promising materials for tissue engineering and model extracellular matrixes for biological studies. While PA hydrogels are conventionally formed via electrostatic screening, new hydrogel... Read More about Peptide Amphiphile Hydrogels Based on Homoternary Cucurbit[8]uril Host-Guest Complexes.

Exploiting the fundamentals of biological organization for the advancement of biofabrication (2021)
Journal Article
Hill, J., Wildman, R., & Mata, A. (2022). Exploiting the fundamentals of biological organization for the advancement of biofabrication. Current Opinion in Biotechnology, 74, 42-54. https://doi.org/10.1016/j.copbio.2021.10.016

The field of biofabrication continues to progress, offering higher levels of spatial control, reproducibility, and functionality. However, we remain far from recapitulating what nature has achieved. Biological systems such as tissues and organs are a... Read More about Exploiting the fundamentals of biological organization for the advancement of biofabrication.

Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology (2021)
Journal Article
Osuna de la Peña, D., Trabulo, S. M. D., Collin, E., Liu, Y., Sharma, S., Tatari, M., …Loessner, D. (2021). Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology. Nature Communications, 12, Article 5623. https://doi.org/10.1038/s41467-021-25921-9

Patient-derived in vivo models of human cancer have become a reality, yet their turnaround time is inadequate for clinical applications. Therefore, tailored ex vivo models that faithfully recapitulate in vivo tumour biology are urgently needed. These... Read More about Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology.

Polymyxin B‐Triggered Assembly of Peptide Hydrogels for Localized and Sustained Release of Combined Antimicrobial Therapy (2021)
Journal Article
Shi, Y., Wareham, D. W., Yuan, Y., Deng, X., Mata, A., & Azevedo, H. S. (2021). Polymyxin B‐Triggered Assembly of Peptide Hydrogels for Localized and Sustained Release of Combined Antimicrobial Therapy. Advanced Healthcare Materials, 10(22), Article 2101465. https://doi.org/10.1002/adhm.202101465

Repurposing old antibiotics into more effective and safer formulations is an emergent approach to tackle the growing threat of antimicrobial resistance. Herein, a peptide hydrogel is reported for the localized and sustained release of polymyxin B (PM... Read More about Polymyxin B‐Triggered Assembly of Peptide Hydrogels for Localized and Sustained Release of Combined Antimicrobial Therapy.

Carboxylated-xyloglucan and peptide amphiphile co-assembly in wound healing (2021)
Journal Article
Ajovalasit, A., Redondo-Gómez, C., Sabatino, M. A., Okesola, B. O., Braun, K., Mata, A., & Dispenza, C. (2021). Carboxylated-xyloglucan and peptide amphiphile co-assembly in wound healing. Regenerative Biomaterials, 8(5), Article rbab040. https://doi.org/10.1093/rb/rbab040

Hydrogel wound dressings can play critical roles in wound healing protecting the wound from trauma or contamination and providing an ideal environment to support the growth of endogenous cells and promote wound closure. This work presents a self-asse... Read More about Carboxylated-xyloglucan and peptide amphiphile co-assembly in wound healing.

De Novo Design of Functional Co-Assembling Organic-Inorganic Hydrogels for Hierarchical Mineralization and Neovascularization (2021)
Journal Article
Okesola, B. O., Mendoza-Martinez, A. K., Cidonio, G., Derkus, B., Boccorh, D. K., Osuna de la Peña, D., …Mata, A. (2021). De Novo Design of Functional Co-Assembling Organic-Inorganic Hydrogels for Hierarchical Mineralization and Neovascularization. ACS Nano, 15(7), 11202–11217. https://doi.org/10.1021/acsnano.0c09814

Synthetic nanostructured materials incorporating both organic and inorganic components offer a unique, powerful and versatile class of materials for widespread applications due to the distinct, yet complementary, nature of the intrinsic properties of... Read More about De Novo Design of Functional Co-Assembling Organic-Inorganic Hydrogels for Hierarchical Mineralization and Neovascularization.

Topographically guided hierarchical mineralization (2021)
Journal Article
Deng, X., Hasan, A., Elsharkawy, S., Tejeda-Montes, E., Tarakina, N. V., Greco, G., …Mata, A. (2021). Topographically guided hierarchical mineralization. Materials Today Bio, 11, Article 100119. https://doi.org/10.1016/j.mtbio.2021.100119

Material platforms based on interaction between organic and inorganic phases offer enormous potential to develop materials that can recreate the structural and functional properties of biological systems. However, the capability of organic-mediated m... Read More about Topographically guided hierarchical mineralization.

Engineered In vitro Models for Pathological Calcification: Routes Toward Mechanistic Understanding (2021)
Journal Article
Radvar, E., Griffanti, G., Tsolaki, E., Bertazzo, S., Nazhat, S. N., Addison, O., …Elsharkawy, S. (2021). Engineered In vitro Models for Pathological Calcification: Routes Toward Mechanistic Understanding. Advanced NanoBiomed Research, 1(8), Article 2100042. https://doi.org/10.1002/anbr.202100042

Physiological calcification plays an essential part in the development of the skeleton and teeth; however, the occurrence of calcification in soft tissues such as the brain, heart, and kidneys associates with health impacts, creating a massive social... Read More about Engineered In vitro Models for Pathological Calcification: Routes Toward Mechanistic Understanding.