All Outputs (13)

Role of Hepatocyte Senescence in the Activation of Hepatic Stellate Cells and Liver Fibrosis Progression (2022)
Journal Article
Wijayasiri, P., Astbury, S., Kaye, P., Oakley, F., Alexander, G. J., Kendall, T. J., & Aravinthan, A. D. (2022). Role of Hepatocyte Senescence in the Activation of Hepatic Stellate Cells and Liver Fibrosis Progression. Cells, 11(14), Article 2221. https://doi.org/10.3390/cells11142221

Hepatocyte senescence is associated with liver fibrosis. However, the possibility of a direct, causal relation between hepatocyte senescence and hepatic stellate cell (HSC) activation was the subject of this study. Liver biopsy specimens obtained fro... Read More about Role of Hepatocyte Senescence in the Activation of Hepatic Stellate Cells and Liver Fibrosis Progression.

Incidence and prevalence of venous thromboembolism in chronic liver disease: A systematic review and meta-analysis (2022)
Journal Article
Subhani, M., Sheth, A., Ahmed, J., Wijayasiri, P., Gardezi, S. A., Enki, D., …Aravinthan, A. D. (2022). Incidence and prevalence of venous thromboembolism in chronic liver disease: A systematic review and meta-analysis. Thrombosis Research, 215, 19-29. https://doi.org/10.1016/j.thromres.2022.05.004

Background and Aims: Historically, bleeding was thought to be a frequent and fatal complication of liver disease. However, thrombosis due to coagulation disorders in cirrhosis remains a real risk. We aim to systematically analyse published articles t... Read More about Incidence and prevalence of venous thromboembolism in chronic liver disease: A systematic review and meta-analysis.

Estimating the clinical prevalence of Wilson’s disease in the UK (2021)
Journal Article
Wijayasiri, P., Hayre, J., Nicholson, E. S., Kaye, P., Wilkes, E. A., Evans, J., …Aravinthan, A. D. (2021). Estimating the clinical prevalence of Wilson’s disease in the UK. JHEP Reports, 3(5), Article 100329. https://doi.org/10.1016/j.jhepr.2021.100329

Background and Aim The clinical prevalence of Wilson’s disease (WD) in the UK remains unknown. The estimated genetic prevalence in the UK, 142/million, is higher than the clinical prevalence (15/million) reported in other European studies. The aim o... Read More about Estimating the clinical prevalence of Wilson’s disease in the UK.

Long-term outcomes of liver transplant recipients followed up in non-transplant centres: Care closer to home (2021)
Journal Article
Tsien, C., Tan, H., Sharma, S., Palaniyappan, N., Wijayasiri, P., Leung, K., …Aravinthan, A. D. (2021). Long-term outcomes of liver transplant recipients followed up in non-transplant centres: Care closer to home. Clinical Medicine, 21(1), e32-e38. https://doi.org/10.7861/clinmed.2020-0609

Introduction: Increasing rates of liver transplantation and improved outcomes have led to greater numbers of transplant recipients followed up in non-transplant centres. Our aim was to document long-term clinical outcomes of liver transplant recipien... Read More about Long-term outcomes of liver transplant recipients followed up in non-transplant centres: Care closer to home.

Comparison of the reverse bevel versus Franseen type endoscopic ultrasound needle (2020)
Journal Article
Wing Chow, C., Asma Haider, S., Ragunath, K., Aithal, G. P., James, M. W., Ortiz-Fernandez-Sordo, J., …Vasan Venkatachalapathy, S. (2020). Comparison of the reverse bevel versus Franseen type endoscopic ultrasound needle. World Journal of Gastrointestinal Endoscopy, 12(9), 266-275. https://doi.org/10.4253/wjge.v12.i9.266

BACKGROUND Reverse bevel (RB) needle is widely used for endoscopic ultrasound fine needle biopsy (EUS-FNB). A 3-plane symmetrical needle with Franseen geometry (FG) has recently become available. AIM To compare the clinical efficacy of FG to that... Read More about Comparison of the reverse bevel versus Franseen type endoscopic ultrasound needle.

The impact of preexisting and post-transplant diabetes mellitus on outcomes following liver transplantation (2019)
Journal Article
Aravinthan, A. D., Fateen, W., Doyle, A. C., Venkatachalapathy, S. V., Issachar, A., Galvin, Z., …Bhat, M. (2019). The impact of preexisting and post-transplant diabetes mellitus on outcomes following liver transplantation. Transplantation, 103(12), 2523-2530. https://doi.org/10.1097/TP.0000000000002757

Background: Diabetes mellitus (DM) is said to adversely affect transplant outcomes. The aim of this study was to investigate the impact of pre-existing and post-transplant DM on liver transplant (LT) recipients. Method: A single centre retrospective... Read More about The impact of preexisting and post-transplant diabetes mellitus on outcomes following liver transplantation.

Telomere, telomerase and liver disease (2017)
Journal Article
Aravinthan, A. D., & Alexander, G. J. (in press). Telomere, telomerase and liver disease. Liver International, 38(1), https://doi.org/10.1111/liv.13630

Characteristics of liver transplant candidates delisted following recompensation and predictors of such delisting in alcohol-related liver disease: a case-control study (2017)
Journal Article
Aravinthan, A. D., Barbas, A. S., Doyle, A. C., Tazari, M., Sapisochin, G., Cattral, M. S., …Renner, E. L. (in press). Characteristics of liver transplant candidates delisted following recompensation and predictors of such delisting in alcohol-related liver disease: a case-control study. Transplant International, https://doi.org/10.1111/tri.13008

Whether and when recovery beyond the need for transplant may occur in patients listed for decompensation remains unclear. This study aimed to investigate the characteristics of patients delisted following recompensation. Seventy-seven patients who we... Read More about Characteristics of liver transplant candidates delisted following recompensation and predictors of such delisting in alcohol-related liver disease: a case-control study.

Liver transplantation is a preferable alternative to palliative therapy for selected patients with advanced hepatocellular carcinoma (2017)
Journal Article
Aravinthan, A. D., Bruni, S. G., Doyle, A. C., Thein, H., Goldaracena, N., Issachar, A., …Sapisochin, G. (2017). Liver transplantation is a preferable alternative to palliative therapy for selected patients with advanced hepatocellular carcinoma. Annals of Surgical Oncology, 24(7), https://doi.org/10.1245/s10434-017-5789-3

Background: Patients with hepatocellular carcinoma (HCC) beyond the traditional criteria (advanced HCC) are typically offered palliation, which is associated with a 3-year survival rate lower than 30%. This study aimed to describe the outcomes for a... Read More about Liver transplantation is a preferable alternative to palliative therapy for selected patients with advanced hepatocellular carcinoma.

First-degree living-related donor liver transplantation in autoimmune liver diseases. (2016)
Journal Article
Aravinthan, A., Doyle, A., Issachar, A., Dib, M., Peretz, D., Cattral, M., …Renner, E. (2016). First-degree living-related donor liver transplantation in autoimmune liver diseases. American Journal of Transplantation, 16(12), 3512-3521. https://doi.org/10.1111/ajt.13828

Liver transplantation (LT) is the treatment of choice for end?stage autoimmune liver diseases. However, the underlying disease may recur in the graft in some 20% of cases. The aim of this study is to determine whether LT using living donor grafts fro... Read More about First-degree living-related donor liver transplantation in autoimmune liver diseases..

Hepatocyte senescence explains conjugated bilirubinaemia in chronic liver failure. (2015)
Journal Article
Aravinthan, A., & Alexander, G. J. (2015). Hepatocyte senescence explains conjugated bilirubinaemia in chronic liver failure. Journal of Hepatology, 63(2), 532-533. https://doi.org/10.1016/j.jhep.2015.03.031

The role of chronic norovirus infection in the enteropathy associated with common variable immunodeficiency (2015)
Journal Article
Woodward, J. M., Aravintham, A., Gkrania-Klotsas, E., YK Cordero-Ng, A., Bandoh, B. N., Liu, H., …Kumararatne, D. (2015). The role of chronic norovirus infection in the enteropathy associated with common variable immunodeficiency. American Journal of Gastroenterology, 110(2), 320–327. https://doi.org/10.1038/ajg.2014.432

Gene polymorphisms of cellular senescence marker p21 and disease progression in non-alcohol-related fatty liver disease (2014)
Journal Article
Mells, G., ARAVINTHAN, A., Allison, M., Leathart, J., Kotronen, A., Yki-Jarvinen, H., …Alexander, G. (2014). Gene polymorphisms of cellular senescence marker p21 and disease progression in non-alcohol-related fatty liver disease. Cell Cycle, 13(9), 1489-1494. https://doi.org/10.4161/cc.28471

Non-alcohol-related fatty liver disease (NAFLD) encompasses a wide spectrum, ranging from steatosis alone to steatohepatitis and fibrosis. Presence of steatohepatitis and fibrosis are key hallmarks of disease progression. Previous studies have demons... Read More about Gene polymorphisms of cellular senescence marker p21 and disease progression in non-alcohol-related fatty liver disease.