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All Outputs (14)

Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research (2022)
Journal Article
Senekowitsch, S., Schick, P., Abrahamsson, B., Augustijns, P., Gießmann, T., Lennernäs, H., …Koziolek, M. (2022). Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research. Pharmaceutics, 14(4), Article 801. https://doi.org/10.3390/pharmaceutics14040801

Drug absorption following oral administration is determined by complex and dynamic interactions between gastrointestinal (GI) physiology, the drug, and its formulation. Since many of these interactions are not fully understood, the COST action on “Un... Read More about Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research.

Feasibility Study of a New MRI Mini-Capsule Device to Measure Whole Gut Transit Time in Pediatric Constipation (2020)
Journal Article
Sharif, H., Abrehart, N., Hoad, C., Murray, K., Perkins, A., Smith, M., …Marciani, L. (2020). Feasibility Study of a New MRI Mini-Capsule Device to Measure Whole Gut Transit Time in Pediatric Constipation. Journal of Pediatric Gastroenterology and Nutrition, 71(5), 604-611. https://doi.org/10.1097/MPG.0000000000002910

Objective: In England, 27,500 children are referred annually to hospital with constipation. An objective measure of whole gut transit time (WGTT) could aid management. The current standard WGTT assessment, the X-ray radiopaque marker (ROM) test, give... Read More about Feasibility Study of a New MRI Mini-Capsule Device to Measure Whole Gut Transit Time in Pediatric Constipation.

Simultaneous measurement of gastric emptying of a soup test meal using MRI and gamma scintigraphy (2020)
Journal Article
Khalaf, A., Hoad, C. L., Blackshaw, E., Alyami, J., Spiller, R. C., Gowland, P. A., …Marciani, L. (2020). Simultaneous measurement of gastric emptying of a soup test meal using MRI and gamma scintigraphy. Diagnostics, 10(3), Article 170. https://doi.org/10.3390/diagnostics10030170

Measurement of gastric emptying is of clinical value for a range of conditions. Gamma scintigraphy (GS) has an established role, but the use of magnetic resonance imaging (MRI) has recently increased. Previous comparison studies between MRI and GS sh... Read More about Simultaneous measurement of gastric emptying of a soup test meal using MRI and gamma scintigraphy.

Nasal Administration and Plasma Pharmacokinetics of Parathyroid Hormone Peptide PTH 1-34 for the Treatment of Osteoporosis (2019)
Journal Article
Pearson, R. G., Masud, T., Blackshaw, E., Naylor, A., Hinchcliffe, M., Jeffery, K., …Perkins, A. C. (2019). Nasal Administration and Plasma Pharmacokinetics of Parathyroid Hormone Peptide PTH 1-34 for the Treatment of Osteoporosis. Pharmaceutics, 11(6), Article 265. https://doi.org/10.3390/pharmaceutics11060265

Nasal delivery of large peptides such as parathyroid 1-34 (PTH 1-34) can benefit from a permeation enhancer to promote absorption across the nasal mucosa into the bloodstream. Previously, we have published an encouraging bioavailability (78%), relati... Read More about Nasal Administration and Plasma Pharmacokinetics of Parathyroid Hormone Peptide PTH 1-34 for the Treatment of Osteoporosis.

Hypoxia imaging with [18F]HX4 PET in squamous cell head and neck cancer: a pilot study for integration into treatment planning (2018)
Journal Article
Betts, H. M., O'Connor, R. A., Christian, J. A., Vinayakamoorthy, V., Foweraker, K., Pascoe, A. C., & Perkins, A. C. (2019). Hypoxia imaging with [18F]HX4 PET in squamous cell head and neck cancer: a pilot study for integration into treatment planning. Nuclear Medicine Communications, 40(1), 73-78. https://doi.org/10.1097/MNM.0000000000000933

Background: Radical chemoradiotherapy is the primary treatment for head and neck cancers in many hospitals. Tumour hypoxia causes radiotherapy resistance, and is an indicator of poor prognosis for patients. Identifying hypoxia to select patients for... Read More about Hypoxia imaging with [18F]HX4 PET in squamous cell head and neck cancer: a pilot study for integration into treatment planning.

In vitro and preclinical assessment of an intranasal spray formulation of parathyroid hormone PTH 1-34 for the treatment of osteoporosis (2017)
Journal Article
Williams, A. J., Jordan, F., King, G., Lewis, A. L., Illum, L., Masud, T., …Pearson, R. G. (in press). In vitro and preclinical assessment of an intranasal spray formulation of parathyroid hormone PTH 1-34 for the treatment of osteoporosis. International Journal of Pharmaceutics, https://doi.org/10.1016/j.ijpharm.2017.10.029

Osteoporosis treatment with PTH 1-34 injections significantly reduces the incidence of bone fracture. Potential further reductions in fracture rate should be observed through nasal spray delivery to address the poor compliance associated with patient... Read More about In vitro and preclinical assessment of an intranasal spray formulation of parathyroid hormone PTH 1-34 for the treatment of osteoporosis.

Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster (2017)
Journal Article
Lewis, J. E., Samms, R. J., Cooper, S., Luckett, J. C., Perkins, A. C., Adams, A. C., …Ebling, F. J. (in press). Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster. Scientific Reports, 7(1), Article 4238. https://doi.org/10.1038/s41598-017-03607-x

FGF21 exerts profound metabolic effects in Siberian hamsters exposed to long day (LD) photoperiods that increase appetite and adiposity, however these effects are attenuated in short day (SD) animals that display hypophagia and reduced adiposity. The... Read More about Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster.

Clinical assessment of gastric emptying and sensory function utilizing gamma scintigraphy: Establishment of reference intervals for the liquid and solid components of the Nottingham test meal in healthy subjects (2017)
Journal Article
Parker, H. L., Tucker, E., Blackshaw, E., Hoad, C., Marciani, L., Perkins, A., …Fox, M. (2017). Clinical assessment of gastric emptying and sensory function utilizing gamma scintigraphy: Establishment of reference intervals for the liquid and solid components of the Nottingham test meal in healthy subjects. Neurogastroenterology and Motility, 29(11), e13122. https://doi.org/10.1111/nmo.13122

Background: Current investigations of stomach function are based on small test meals that do not reliably induce symptoms and analysis techniques that rarely detect clinically relevant dysfunction. This study presents the reference intervals of the m... Read More about Clinical assessment of gastric emptying and sensory function utilizing gamma scintigraphy: Establishment of reference intervals for the liquid and solid components of the Nottingham test meal in healthy subjects.

Synthesis, in vitro evaluation, and radiolabeling of fluorinated puromycin analogues: potential candidates for PET imaging of protein synthesis (2016)
Journal Article
Betts, H. M., Sephton, S. M., Tong, C., Awais, R., Hill, P. J., Perkins, A. C., & Aigbirhio, F. I. (2016). Synthesis, in vitro evaluation, and radiolabeling of fluorinated puromycin analogues: potential candidates for PET imaging of protein synthesis. Journal of Medicinal Chemistry, 59(20), 9422-9430. https://doi.org/10.1021/acs.jmedchem.6b00968

There is currently no ideal radiotracer for imaging protein synthesis rate (PSR) by positron emission tomography (PET). Existing fluorine-18 labelled amino acid-based radiotracers predominantly visualize amino acid transporter processes, and in many... Read More about Synthesis, in vitro evaluation, and radiolabeling of fluorinated puromycin analogues: potential candidates for PET imaging of protein synthesis.

Development and validation of a large, modular test meal with liquid and solid components for assessment of gastric motor and sensory function by non-invasive imaging (2016)
Journal Article
Parker, H. L., Tucker, E., Hoad, C., Pal, A., Costigan, C., Hudders, N., …Fox, M. R. (2016). Development and validation of a large, modular test meal with liquid and solid components for assessment of gastric motor and sensory function by non-invasive imaging. Neurogastroenterology and Motility, 28(4), 554-568. https://doi.org/10.1111/nmo.12752

Background: Current investigations of stomach function are based on small test meals that do not reliably induce symptoms and analysis techniques that rarely detect clinically relevant dysfunction. This study introduces the large ‘Nottingham Test Mea... Read More about Development and validation of a large, modular test meal with liquid and solid components for assessment of gastric motor and sensory function by non-invasive imaging.

Antibody-mediated inhibition of the FGFR1c isoform induces a catabolic lean state in Siberian hamsters (2015)
Journal Article
Samms, R. J., Lewis, J. E., Lory, A., Fowler, M. J., Cooper, S., Warner, A., …Ebling, F. J. (2015). Antibody-mediated inhibition of the FGFR1c isoform induces a catabolic lean state in Siberian hamsters. Current Biology, 25(22), https://doi.org/10.1016/j.cub.2015.10.010

Hypothalamic tanycytes are considered to function as sensors of peripheral metabolism [1]. To facilitate this role, they express a wide range of receptors, including fibroblast growth factor receptor 1 (FGFR1). Using a monoclonal antibody (IMC-H7) th... Read More about Antibody-mediated inhibition of the FGFR1c isoform induces a catabolic lean state in Siberian hamsters.

Measurement of gastric meal and secretion volumes using magnetic resonance imaging (2015)
Journal Article
Hoad, C., Parker, H., Hudders, N., Costigan, C., Cox, E., Perkins, A., …Gowland, P. (2015). Measurement of gastric meal and secretion volumes using magnetic resonance imaging. Physics in Medicine and Biology, 60(3), 1367-1383. https://doi.org/10.1088/0031-9155/60/3/1367

MRI can assess multiple gastric functions without ionizing radiation. However, time consuming image acquisition and analysis of gastric volume data, plus confounding of gastric emptying measurements by gastric secretions mixed with the test meal have... Read More about Measurement of gastric meal and secretion volumes using magnetic resonance imaging.

Novel MRI tests of orocecal transit time and whole gut transit time: studies in normal subjects (2013)
Journal Article
Chaddock, G., Lam, C., Hoad, C., Costigan, C., Cox, E. F., Placidi, E., …Spiller, R. C. (2014). Novel MRI tests of orocecal transit time and whole gut transit time: studies in normal subjects. Neurogastroenterology and Motility, 26(2), 205-214. https://doi.org/10.1111/nmo.12249

Background: Colonic transit tests are used to manage patients with Functional Gastrointestinal Disorders. Some tests used expose patients to ionizing radiation. The aim of this study was to compare novel magnetic resonance imaging (MRI) tests for mea... Read More about Novel MRI tests of orocecal transit time and whole gut transit time: studies in normal subjects.