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Persistence of scrapie infectivity within a farm environment after cleaning and decontamination

Hawkins, Steve A.C.; Simmons, Hugh A.; Gough, Kevin C.; Maddison, Ben C.

Authors

Steve A.C. Hawkins

Hugh A. Simmons

Kevin C. Gough

Ben C. Maddison



Abstract

Scrapie of sheep/goats and Chronic Wasting Disease (CWD) of deer/elk are contagious prion diseases where environmental reservoirs are directly implicated in the transmission of disease. In this study the effectiveness of recommended scrapie farm decontamination regimes was evaluated by a sheep bioassay using buildings naturally contaminated with scrapie. Pens within a farm building were treated with either 20,000ppm free chorine solution for one hour, or were treated to same but were followed with painting and full re-galvanisation or replacement of metalwork within the pen. Scrapie susceptible lambs of the PRNP genotype VRQ/VRQ were reared within these pens and their scrapie status was monitored by RAMALT. All animals became infected over an 18-month period, even in the pen that had been subject to the most stringent decontamination process. This data suggests that recommended current guidelines for the decontamination of farm buildings following outbreaks of scrapie do little to reduce the titre of infectious scrapie material and that environmental re-contamination could also be an issue associated with these premises.

Citation

Hawkins, S. A., Simmons, H. A., Gough, K. C., & Maddison, B. C. (2015). Persistence of scrapie infectivity within a farm environment after cleaning and decontamination. Veterinary Record, 176(4), doi:10.1136/vr.102743

Journal Article Type Article
Publication Date Jan 1, 2015
Deposit Date Sep 24, 2015
Publicly Available Date Sep 24, 2015
Journal Veterinary Record
Print ISSN 0042-4900
Electronic ISSN 0042-4900
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 176
Issue 4
DOI https://doi.org/10.1136/vr.102743
Public URL http://eprints.nottingham.ac.uk/id/eprint/30243
Publisher URL http://veterinaryrecord.bmj.com/content/176/4/99.full
Related Public URLs http://veterinaryrecord.bmj.com/content/early/2014/10/31/vr.102743.full.pdf+html
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information Copyright British Veterinary Association.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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