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The effect of paratuberculosis on milk yield—a systematic review and meta-analysis

McAloon, Conor G.; Whyte, Paul; More, Simon J.; Green, Martin J.; O’Grady, Luke; Garcia, AnaBelen; Doherty, Michael L.

Authors

Conor G. McAloon

Paul Whyte

Simon J. More

MARTIN GREEN martin.green@nottingham.ac.uk
Professor of Cattle Health & Epidemiology

Luke O’Grady

AnaBelen Garcia

Michael L. Doherty



Abstract

Bovine paratuberculosis is a disease characterized by chronic granulomatous enteritis causing protein-losing enteropathy. Adverse effects on animal productivity are key drivers in the attempt to control paratuberculosis at the farm level. Economic models require an accurate estimation of the production effects associated with paratuberculosis. The aim of this study was to conduct a systematic review and meta-analysis to investigate the effect of paratuberculosis on milk production. A total of 20 effect estimates from 15 studies were included in the final meta-analysis. Substantial between-study heterogeneity was observed. Subgroup analysis by case definition and study design was carried out to investigate heterogeneity. The majority of between-study variation was attributed to studies that defined cases on serology. Calculation of a pooled effect estimate was only appropriate for studies that defined cases by organism detection. A reduction in milk yield, corrected for lactation number and herd of origin of 1.87 kg/d, equivalent to 5.9% of yield, was associated with fecal culture or PCR positivity in individual cows.

Citation

McAloon, C. G., Whyte, P., More, S. J., Green, M. J., O’Grady, L., Garcia, A., & Doherty, M. L. (2016). The effect of paratuberculosis on milk yield—a systematic review and meta-analysis. Journal of Dairy Science, 99(2), https://doi.org/10.3168/jds.2015-10156

Journal Article Type Article
Acceptance Date Oct 23, 2015
Online Publication Date Dec 10, 2015
Publication Date Feb 1, 2016
Deposit Date Oct 20, 2016
Publicly Available Date Oct 20, 2016
Journal Journal of Dairy Science
Print ISSN 0022-0302
Electronic ISSN 1525-3198
Publisher American Dairy Science Association
Peer Reviewed Peer Reviewed
Volume 99
Issue 2
DOI https://doi.org/10.3168/jds.2015-10156
Keywords paratuberculosis; Johne’s disease; meta-analysis; milk yield
Public URL http://eprints.nottingham.ac.uk/id/eprint/37799
Publisher URL http://www.sciencedirect.com/science/article/pii/S0022030215008978
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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