The effect of paratuberculosis on milk yield—a systematic review and meta-analysis

McAloon, Conor G.; Whyte, Paul; More, Simon J.; Green, Martin J.; O�Grady, Luke; Garcia, AnaBelen; Doherty, Michael L.

Abstract

Bovine paratuberculosis is a disease characterized by chronic granulomatous enteritis causing protein-losing enteropathy. Adverse effects on animal productivity are key drivers in the attempt to control paratuberculosis at the farm level. Economic models require an accurate estimation of the production effects associated with paratuberculosis. The aim of this study was to conduct a systematic review and meta-analysis to investigate the effect of paratuberculosis on milk production. A total of 20 effect estimates from 15 studies were included in the final meta-analysis. Substantial between-study heterogeneity was observed. Subgroup analysis by case definition and study design was carried out to investigate heterogeneity. The majority of between-study variation was attributed to studies that defined cases on serology. Calculation of a pooled effect estimate was only appropriate for studies that defined cases by organism detection. A reduction in milk yield, corrected for lactation number and herd of origin of 1.87 kg/d, equivalent to 5.9% of yield, was associated with fecal culture or PCR positivity in individual cows.

Citation

McAloon, C. G., Whyte, P., More, S. J., Green, M. J., O’Grady, L., Garcia, A., & Doherty, M. L. (2016). The effect of paratuberculosis on milk yield—a systematic review and meta-analysis. Journal of Dairy Science, 99(2), https://doi.org/10.3168/jds.2015-10156

• Journal Article Type: Article
• Acceptance Date: Oct 23, 2015
• Online Publication Date: Dec 10, 2015
• Publication Date: Feb 1, 2016
• Deposit Date: Oct 20, 2016
• Publicly Available Date: Oct 20, 2016
• Journal: Journal of Dairy Science
• Print ISSN: 0022-0302
• Electronic ISSN: 1525-3198
• Publisher: American Dairy Science Association
• Peer Reviewed: Peer Reviewed
• Volume: 99
• Issue: 2
• DOI: https://doi.org/10.3168/jds.2015-10156
• Keywords: paratuberculosis; Johne’s disease; meta-analysis; milk yield
• Public URL: https://nottingham-repository.worktribe.com/output/978526
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S0022030215008978