Skip to main content

Research Repository

Advanced Search

Imaging gray matter with concomitant null point imaging from the phase sensitive inversion recovery sequence

Mougin, Olivier; Abdel-Fahim, Rasha; Dineen, Robert; Pitiot, Alain; Evangelou, Nikos; Gowland, Penny


Rasha Abdel-Fahim

Alain Pitiot



To present an improved three-dimensional (3D) interleaved phase sensitive inversion recovery (PSIR) sequence including a concomitantly acquired new contrast, null point imaging (NPI), to help detect and classify abnormalities in cortical gray matter.

The 3D gradient echo PSIR images were acquired at 0.6 mm isotropic resolution on 11 multiple sclerosis (MS) patients and 9 controls subjects using a 7 Tesla (T) MRI scanner, and 2 MS patients at 3T. Cortical abnormalities were delineated on the NPI/PSIR data and later classified according to position in the cortex.

The NPI helped detect cortical lesions within the cortical ribbon with increased, positive contrast compared with the PSIR. It also provided improved intrinsic delineation of the ribbon, increasing confidence in classifying the lesions' locations.

The proposed PSIR facilitates the classification of cortical lesions by providing two T1-weighted 3D datasets with isotropic resolution, including the NPI showing cortical lesions with clear delineation of the gray/white matter boundary and minimal partial volume effects. Magn Reson Med 76:1512–1516, 2016. © 2015 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.


Mougin, O., Abdel-Fahim, R., Dineen, R., Pitiot, A., Evangelou, N., & Gowland, P. (2016). Imaging gray matter with concomitant null point imaging from the phase sensitive inversion recovery sequence. Magnetic Resonance in Medicine, 76(5), 1512-1516.

Journal Article Type Article
Acceptance Date Oct 27, 2015
Online Publication Date Nov 24, 2015
Publication Date 2016-11
Deposit Date Jan 5, 2017
Publicly Available Date Jan 5, 2017
Journal Magnetic Resonance in Medicine
Print ISSN 0740-3194
Electronic ISSN 1522-2594
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 76
Issue 5
Pages 1512-1516
Keywords magnetic resonance imaging; multiple sclerosis; cerebral cortex; imaging; gray matter
Public URL
Publisher URL


MRM_26061_online.pdf (3.7 Mb)

Copyright Statement
Copyright information regarding this work can be found at the following address:

You might also like

Downloadable Citations