Cheng-Chang Yang firstname.lastname@example.org
Excitatory repetitive Transcranial Magnetic Stimulation applied to the right inferior frontal gyrus has no effect on motor or cognitive impulsivity in healthy adults
Yang, Cheng-Chang; Khalifa, Najat; Völlm, Birgit
Najat Khalifa email@example.com
Birgit Völlm firstname.lastname@example.org
Background: Impulsivity is a multi-faceted concept. It is a crucial feature of many neuropsychiatric disorders. Three subtypes of impulsivity have been identified: motor, temporal, and cognitive impulsivity. Existing evidence suggests that the right inferior frontal gyrus (rIFG) plays a crucial role in impulsivity, and such a role has been elucidated using inhibitory repetitive transcranial magnetic stimulation (rTMS). There is a dearth of studies using excitatory rTMS at the rIFG, an important gap in the literature this study aimed to address.
Methods: Twenty healthy male adults completed a single-blind sham-controlled randomised crossover study aimed at assessing the efficacy of rTMS in the neuromodulation of impulsivity. This involved delivering 10-Hz excitatory rTMS to the rIFG at the intensity of 100% motor threshold with 900 pulses per session. Trait impulsivity was measured at baseline using the Barrett Impulsiveness Scale and UPPS-P Impulsiveness Scale. The Stop
Signal Task (SST) and Information Sampling Task (IST), administered before andafter rTMS sessions, were used as behavioural measures of impulsivity.
Results: No significant changes on any measures from either SST or IST after active rTMS at the rIFG compared to the sham-controlled condition were found.
Conclusions: Excitatory rTMS applied to the rIFG did not have a statistically significant effect on response inhibition and reflective/cognitive impulsivity. Further research is required before drawing firm conclusions. This may involve a larger sample of highly impulsive individuals, a different stimulation site or a different TMS modality such as theta burst stimulation.
|Journal Article Type||Article|
|Publication Date||Jul 16, 2018|
|Journal||Behavioural Brain Research|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Yang, C., Khalifa, N., & Völlm, B. (2018). Excitatory repetitive Transcranial Magnetic Stimulation applied to the right inferior frontal gyrus has no effect on motor or cognitive impulsivity in healthy adults. Behavioural Brain Research, 347, https://doi.org/10.1016/j.bbr.2018.02.047|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0|
TMS impulsivity 19022018 for Behavioural Brain Research-without tracked changes.pdf
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0
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