Endocrine therapy for breast cancer: a model of hormonal manipulation

Johnston, Simon J.; Cheung, Kwok-Leung

Abstract

Oestrogen receptor (ER) is the driving transcription factor in 70% of breast cancer. Endocrine therapies targeting the ER represent one of the most successful anticancer strategies to date. In the clinic, novel targeted agents are now being exploited in combination with established endocrine therapies to maximise efficacy. However, clinicians must balance this gain against the risk to patients of increased side effects with combination therapies. This article provides a succinct outline of the principles of hormonal manipulation in breast cancer, alongside the key evidence that underpins current clinical practice. As the role of endocrine therapy in breast cancer continues to expand, the challenge is to interpret the data and select the optimal strategy for a given clinical scenario.

Citation

Johnston, S. J., & Cheung, K. (in press). Endocrine therapy for breast cancer: a model of hormonal manipulation. Oncology and Therapy, https://doi.org/10.1007/s40487-018-0062-x

• Journal Article Type: Article
• Acceptance Date: Jun 21, 2018
• Online Publication Date: Jul 10, 2018
• Deposit Date: Jul 17, 2018
• Publicly Available Date: Jul 17, 2018
• Journal: Oncology and Therapy
• Electronic ISSN: 2366-1089
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1007/s40487-018-0062-x
• Keywords: Breast cancer; Combination therapy; Endocrine therapy; Hormone; Oestrogen receptor; Targeted therapy
• Public URL: https://nottingham-repository.worktribe.com/output/946037
• Publisher URL: https://link.springer.com/article/10.1007%2Fs40487-018-0062-x