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Systematic review of the evidence for sustained efficacy of dietary interventions for reducing appetite or energy intake

Halford, Jason C.G.; Masic, Una; Marseaux, Cyril F.M.; Jones, Andrew J.; Lluch, Anne; Marciani, Luca; Mars, Monica; Vinoy, Sophie; Westerterp-Plantenga, Margriet; Mela, David J.


Jason C.G. Halford

Una Masic

Cyril F.M. Marseaux

Andrew J. Jones

Anne Lluch

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Professor of Gastrointestinal Imaging

Monica Mars

Sophie Vinoy

Margriet Westerterp-Plantenga

David J. Mela


We assessed evidence for changes in efficacy of food-based interventions aimed at reducing appetite or energy intake (EI), and whether this could be used to provide guidance on trial design.
A systematic search identified randomized controlled trials testing sustained efficacy of diets, foods, supplements or food ingredients on appetite and/or EI. Trials had to include sufficient exposure duration (?3 days) with appetite and/or EI measured after both acute and repeated exposures.
Twenty-six trials met the inclusion criteria and reported data allowing for assessment of the acute and chronic effects of interventions. Most (21/26) measured appetite outcomes and over half (14/26) had objective measures of EI. A significant acute effect of the intervention was retained in 10 of 12 trials for appetite outcomes, and six of nine studies for EI. Initial effects were most likely retained where these were more robust and studies adequately powered. Where the initial, acute effect was not statistically significant, a significant effect was later observed in only two of nine studies for appetite and none of five studies for EI.
Maintenance of intervention effects on appetite or EI needs to be confirmed, but seem likely where acute effects are robust and replicable in adequately powered studies.


Halford, J. C., Masic, U., Marseaux, C. F., Jones, A. J., Lluch, A., Marciani, L., …Mela, D. J. (2018). Systematic review of the evidence for sustained efficacy of dietary interventions for reducing appetite or energy intake. Obesity Reviews, 19(10), 1329-1339.

Journal Article Type Article
Acceptance Date Apr 16, 2018
Online Publication Date Jun 25, 2018
Publication Date 2018-10
Deposit Date May 21, 2018
Publicly Available Date Jun 25, 2018
Journal Obesity Reviews
Print ISSN 1467-7881
Electronic ISSN 1467-789X
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 19
Issue 10
Pages 1329-1339
Keywords Study duration, Satiety, Energy intake, Appetite
Public URL
Publisher URL


Halford_et_al-2018-Obesity_Reviews.pdf (224 Kb)

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