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Risk profiles for heavy drinking in adolescence: differential effects of gender

Seo, Sambu; Beck, Anne; Matthis, Caroline; Genauck, Alexander; Banaschewski, Tobias; Bokde, Arun L.W.; Bromberg, Uli; Büchel, Christian; Quinlan, Erin Burke; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Gowland, Penny; Ittermann, Bernd; Martinot, Jean-Luc; Paillère Martinot, Marie-Laure; Nees, Frauke; Papadopoulos Orfanos, Dimitri; Poustka, Luise; Hohmann, Sarah; Fröhner, Juliane H.; Smolka, Michael N.; Walter, Henrik; Whelan, Robert; Desrivières, Sylvane; Heinz, Andreas; Schumann, Gunter; Obermayer, Klaus

Authors

Sambu Seo

Anne Beck

Caroline Matthis

Alexander Genauck

Tobias Banaschewski

Arun L.W. Bokde

Uli Bromberg

Christian Büchel

Erin Burke Quinlan

Herta Flor

Vincent Frouin

Hugh Garavan

Bernd Ittermann

Jean-Luc Martinot

Marie-Laure Paillère Martinot

Frauke Nees

Dimitri Papadopoulos Orfanos

Luise Poustka

Sarah Hohmann

Juliane H. Fröhner

Michael N. Smolka

Henrik Walter

Robert Whelan

Sylvane Desrivières

Andreas Heinz

Gunter Schumann

Klaus Obermayer



Abstract

Abnormalities across different domains of neuropsychological functioning may constitute a risk factor for heavy drinking during adolescence and for developing alcohol use disorders later in life. However, the exact nature of such multi‐domain risk profiles is unclear, and it is further unclear whether these risk profiles differ between genders. We combined longitudinal and cross‐sectional analyses on the large IMAGEN sample (N ≈ 1000) to predict heavy drinking at age 19 from gray matter volume as well as from psychosocial data at age 14 and 19—for males and females separately. Heavy drinking was associated with reduced gray matter volume in 19‐year‐olds' bilateral ACC, MPFC, thalamus, middle, medial and superior OFC as well as left amygdala and anterior insula and right inferior OFC. Notably, this lower gray matter volume associated with heavy drinking was stronger in females than in males. In both genders, we observed that impulsivity and facets of novelty seeking at the age of 14 and 19, as well as hopelessness at the age of 14, are risk factors for heavy drinking at the age of 19. Stressful life events with internal (but not external) locus of control were associated with heavy drinking only at age 19. Personality and stress assessment in adolescents may help to better target counseling and prevention programs. This might reduce heavy drinking in adolescents and hence reduce the risk of early brain atrophy, especially in females. In turn, this could additionally reduce the risk of developing alcohol use disorders later in adulthood.

Journal Article Type Article
Journal Addiction Biology
Print ISSN 1355-6215
Electronic ISSN 1355-6215
Publisher Wiley
Peer Reviewed Peer Reviewed
APA6 Citation Seo, S., Beck, A., Matthis, C., Genauck, A., Banaschewski, T., Bokde, A. L., …Obermayer, K. (in press). Risk profiles for heavy drinking in adolescence: differential effects of gender. Addiction Biology, doi:10.1111/adb.12636
DOI https://doi.org/10.1111/adb.12636
Publisher URL https://onlinelibrary.wiley.com/doi/abs/10.1111/adb.12636
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
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