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Translating childhood brain tumour research into clinical practice: the experience of molecular classification and diagnostics

Ritzmann, Timothy A.; Grundy, Richard G.

Authors

RICHARD GRUNDY richard.grundy@nottingham.ac.uk
Professor of Paediatric Neuro-Oncology



Abstract

Diagnosis and treatment of paediatric brain tumours has shown limited progress over the last half century. However, in the past 10 years the development of molecular techniques for investigating these tumours has expanded exponentially. The use of methylation profiling, gene expression analysis and the identification of gene fusions are forming the basis for improved diagnostic criteria and new treatment approaches. Knowledge and practice in this area is now beginning to expand beyond the research field and into the clinical setting. As the Chief Medical Officer highlighted in July 2017, an understanding of molecular medicine and its implications for both patients and the health economy is important for all clinicians. In this article, we summarise important recent advances in molecular medicine in childhood brain tumour research using the three most common types of paediatric brain tumour; pilocytic astrocytoma, medulloblastoma and ependymoma as illustrative examples.

Citation

Ritzmann, T. A., & Grundy, R. G. (2018). Translating childhood brain tumour research into clinical practice: the experience of molecular classification and diagnostics. Paediatrics and Child Health, 28(4), https://doi.org/10.1016/j.paed.2018.01.006

Journal Article Type Article
Acceptance Date Jan 23, 2018
Online Publication Date Mar 1, 2018
Publication Date Apr 30, 2018
Deposit Date Apr 27, 2018
Publicly Available Date Mar 29, 2024
Journal Paediatrics and Child Health
Print ISSN 1205-7088
Electronic ISSN 1751-7222
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 28
Issue 4
DOI https://doi.org/10.1016/j.paed.2018.01.006
Keywords Brain tumours; DNA methylation; Ependymoma; Fusion genes; Medulloblastoma; Molecular diagnostics; Pilocytic astrocytoma
Public URL https://nottingham-repository.worktribe.com/output/930009
Publisher URL https://www.sciencedirect.com/science/article/pii/S1751722218300064?via%3Dihub