A fellowship of Ring1 maintains AML stem cells

Heery, David M.

Abstract

Polycomb repressive complex 1 (PRC1) and PRC2 are transcriptional repressors that function as key regulators of the self-renewal and differentiation (cell lineage specification) pathways in stem cells. In this issue of Blood, Shima et al1 report that 2 ubiquitin ligases (Ring1A and Ring1B), which are key components of PRC1 complexes, are essential for the establishment and maintenance of acute myeloid leukemia (AML) in mouse models.

Citation

Heery, D. M. (2018). A fellowship of Ring1 maintains AML stem cells. Blood, 131(16), 1771-1773. https://doi.org/10.1182/blood-2018-02-832121

• Journal Article Type: Article
• Acceptance Date: Feb 22, 2018
• Online Publication Date: Apr 19, 2018
• Publication Date: Apr 19, 2018
• Deposit Date: Jul 12, 2018
• Publicly Available Date: Apr 20, 2019
• Journal: Blood
• Print ISSN: 0006-4971
• Electronic ISSN: 1528-0020
• Publisher: American Society of Hematology
• Peer Reviewed: Peer Reviewed
• Volume: 131
• Issue: 16
• Pages: 1771-1773
• DOI: https://doi.org/10.1182/blood-2018-02-832121
• Public URL: https://nottingham-repository.worktribe.com/output/926866
• Publisher URL: http://dx.doi.org/10.1182/blood-2018-02-832121
• Additional Information: This research was originally published in Blood. Heery, David M.. A fellowship of Ring1 maintains AML stem cells. Blood. 2018;Vol 131:pp. 1771-1773. © 2018 the American Society of Hematology.