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Immune infiltration in invasive lobular breast cancer

Desmedt, Christine; Salgado, Roberto; Fornili, Marco; Pruneri, Giancarlo; Gert Van den Eynden, Gert; Zoppoli, Gabriele; Rothé, Françoise; Buisseret, Laurence; Garaud, Soizic; Willard-Gallo, Karen; Brown, David; Bareche, Yacine; Rouas, Ghizlane; Galant, Christine; Bertucci, Francois; Loi, Sherene; Viale, Giuseppe; Di Leo, Angelo; Green, Andrew R.; Ellis, Ian O.; Rakha, Emad A.; Larsimont, Denis; Biganzoli, Elia; Sotiriou, Christos


Christine Desmedt

Roberto Salgado

Marco Fornili

Giancarlo Pruneri

Gert Gert Van den Eynden

Gabriele Zoppoli

Françoise Rothé

Laurence Buisseret

Soizic Garaud

Karen Willard-Gallo

David Brown

Yacine Bareche

Ghizlane Rouas

Christine Galant

Francois Bertucci

Sherene Loi

Giuseppe Viale

Angelo Di Leo

Professor of Breast Cancer Pathology

Denis Larsimont

Elia Biganzoli

Christos Sotiriou


Background: Invasive lobular breast cancer (ILC) is the second most common histological subtype of breast cancer after invasive ductal cancer (IDC). Here, we aimed at evaluating the prevalence, levels and composition of tumor infiltrating lymphocytes (TIL) and their association with clinico-pathological, and outcome variables in ILC, and to compare it with IDC.
Methods: We considered two patient series with TIL data: a multi-centric retrospective series (n=614) and the BIG 02-98 study (n=149 ILC and 807 IDC). We compared immune subsets identified by immuno-histochemistry in the ILC (n=159) and IDC (n=468) patients from the Nottingham series, as well as the CIBERSORT immune profiling of the ILC (n=98) and IDC (n=388) METABRIC and TCGA patients. All ILC/IDC comparisons were done in ER-positive/HER2-negative tumors. All statistical tests were two-sided.
Results: TIL levels were statistically significantly lower in ILC compared to IDC (fold change =0.79; 95%CI: 0.70-0.88, P

Journal Article Type Article
Publication Date Jul 1, 2018
Journal Journal of the National Cancer Institute
Print ISSN 0027-8874
Electronic ISSN 1460-2105
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 110
Issue 7
Pages 768–776
APA6 Citation Desmedt, C., Salgado, R., Fornili, M., Pruneri, G., Gert Van den Eynden, G., Zoppoli, G., …Sotiriou, C. (2018). Immune infiltration in invasive lobular breast cancer. JNCI: Journal of the National Cancer Institute, 110(7), 768–776.
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Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf