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Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging

Zamberlan, F.; Turyanska, L.; Patanè, A.; Liu, Z.; Williams, H.E.L.; Fay, M.W.; Clarke, P.A.; Imamura, Y.; Jin, T.; Bradshaw, T.D.; Thomas, N.R.; Grabowska, A.M.

Authors

F. Zamberlan

L. Turyanska

A. Patanè

Z. Liu

H.E.L. Williams

P.A. Clarke

Y. Imamura

T. Jin

T.D. Bradshaw

N.R. Thomas

A.M. Grabowska



Abstract

The short shelf-life of water-soluble quantum dots (QDs) due to colloidal instability represents a major drawback to their exploitation. This work examines the colloidal stability of PbS nanoparticles capped with dihydrolipoic acid–polyethylene glycol (DHLA–PEG) ligands terminated with functional groups such as –NH 2 , –COOH, OMe and –N3 and their application for in vivo imaging. We prove a mechanism of colloidal instability and develop a strategy to produce for the first time stable PEG-capped PbS quantum dots with high quantum yield and optical emission in the first and the second near-infrared (NIR) windows of low absorption of biological tissues. The NIR imaging of in vivo biodistribution is demonstrated at wavelengths 4 1000 nm, with benefits of reduced tissue absorption and light scattering. The stability, biocompatibility and potential for further QD functionalization open up realistic prospects for non-invasive bioimaging applications.

Journal Article Type Article
Journal Journal of Materials Chemistry B
Print ISSN 2050-750X
Electronic ISSN 2050-7518
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 6
APA6 Citation Zamberlan, F., Turyanska, L., Patanè, A., Liu, Z., Williams, H., Fay, M., …Grabowska, A. (in press). Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging. Journal of Materials Chemistry B, 6, https://doi.org/10.1039/c7tb02912h
DOI https://doi.org/10.1039/c7tb02912h
Publisher URL http://pubs.rsc.org/en/content/articlehtml/2018/tb/c7tb02912h
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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