Disinfector-Assisted Low Temperature Reduced Graphene Oxide-Protein Surgical Dressing for the Postoperative Photothermal Treatment of Melanoma

Wu, Yuanhao; Yang, Junyao; van Teijlingen, Alexander; Berardo, Alice; Corridori, Ilaria; Feng, Jingyu; Xu, Jing; Titirici, Maria‐Magdalena; Rodriguez‐Cabello, Jose Carlos; Pugno, Nicola M.; Sun, Jiaming; Wang, Wen; Tuttle, Tell; Mata, Alvaro

Abstract

Materials that combine the functionalities of both of proteins and graphene are of great interest for the engineering of biosensing, drug delivery, and regenerative devices. Graphene oxide (GO) offers an opportunity to design GO-protein interactions but the need for harsh reduction processes to enable GO photoexcitation remains a limitation. A disinfector-assisted low temperature method to reduce GO-protein materials and fabricate surgical dressings with tuneable photothermal efficiency and bioactive properties for the postoperative treatment of melanoma is reported. The approach harnesses the capacity of 70% ethanol to penetrate the protein shell of microorganisms to infiltrate GO-protein complexes and reduce GO at low temperature (85°C) while maintaining the material structure and bioactivity. Both experiments and coarse-grained simulations are used to describe the reduction process and assess the material properties. In vitro and in vivo validation revealed the capacity of the dressings to prevent tumor recurrence and promote healing after tumor resection.

Citation

Wu, Y., Yang, J., van Teijlingen, A., Berardo, A., Corridori, I., Feng, J., …Mata, A. (2022). Disinfector-Assisted Low Temperature Reduced Graphene Oxide-Protein Surgical Dressing for the Postoperative Photothermal Treatment of Melanoma. Advanced Functional Materials, 32(38), Article 2205802. https://doi.org/10.1002/adfm.202205802

• Journal Article Type: Article
• Acceptance Date: Jun 15, 2022
• Online Publication Date: Jul 8, 2022
• Publication Date: Sep 19, 2022
• Deposit Date: Jul 14, 2022
• Publicly Available Date: Jul 15, 2022
• Journal: Advanced Functional Materials
• Print ISSN: 1616-301X
• Electronic ISSN: 1616-3028
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 32
• Issue: 38
• Article Number: 2205802
• DOI: https://doi.org/10.1002/adfm.202205802
• Keywords: Electrochemistry; Condensed Matter Physics; Biomaterials; Electronic, Optical and Magnetic Materials
• Public URL: https://nottingham-repository.worktribe.com/output/8953251
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1002/adfm.202205802