Daniel J. Wilkinson
Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism
Wilkinson, Daniel J.; Hossain, T.; Limb, Marie C.; Phillips, Bethan E.; Lund, J.; Williams, John P.; Brook, Matthew S.; Cegielski, Jessica; Philp, A.; Ashcroft, S.; Rathmacher, J.A.; Szewczyk, Nathaniel J.; Smith, K.; Atherton, Philip J.
Marie C. Limb
Bethan E. Phillips
John P. Williams
Matthew S. Brook
Nathaniel J. Szewczyk
Philip J. Atherton
Background & aims: β-hydroxy-β-methylbutyrate (HMB) is purported as a key nutritional supplement for the preservation of muscle mass in health, disease and as an ergogenic aid in exercise. Of the two available forms of HMB (calcium (Ca-HMB) salt or free acid (FA-HMB)) – differences in plasma bioavailability have been reported. We previously reported that ∼3 g oral FA-HMB increased muscle protein synthesis (MPS) and reduced muscle protein breakdown (MPB). The objective of the present study was to quantify muscle protein metabolism responses to oral Ca-HMB.
Methods: Eight healthy young males received a primed constant infusion of 1,2 13C2 leucine and 2H5 phenylalanine to assess MPS (by tracer incorporation in myofibrils) and MPB (via arterio-venous (A-V) dilution) at baseline and following provision of ∼3 g of Ca-HMB; muscle anabolic (MPS) and catabolic (MPB) signalling was assessed via immunoblotting.
Results: Ca-HMB led a significant and rapid (
|Journal Article Type||Article|
|Publication Date||Oct 6, 2017|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Wilkinson, D. J., Hossain, T., Limb, M. C., Phillips, B. E., Lund, J., Williams, J. P., …Atherton, P. J. (2017). Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism. Clinical Nutrition, doi:10.1016/j.clnu.2017.09.024. ISSN 0261-5614|
|Keywords||β-Hydroxy-β-methylbutyrate; Skeletal muscle; Protein metabolism; Anabolism|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0|
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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