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Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism

Wilkinson, Daniel J.; Hossain, T.; Limb, Marie C.; Phillips, Bethan E.; Lund, J.; Williams, John P.; Brook, Matthew S.; Cegielski, Jessica; Philp, A.; Ashcroft, S.; Rathmacher, J.A.; Szewczyk, Nathaniel J.; Smith, K.; Atherton, Philip J.

Authors

Daniel J. Wilkinson

T. Hossain

Marie C. Limb

Bethan E. Phillips

J. Lund

John P. Williams

Matthew S. Brook

Jessica Cegielski

A. Philp

S. Ashcroft

J.A. Rathmacher

Nathaniel J. Szewczyk

K. Smith

Philip J. Atherton



Abstract

Background & aims: β-hydroxy-β-methylbutyrate (HMB) is purported as a key nutritional supplement for the preservation of muscle mass in health, disease and as an ergogenic aid in exercise. Of the two available forms of HMB (calcium (Ca-HMB) salt or free acid (FA-HMB)) – differences in plasma bioavailability have been reported. We previously reported that ∼3 g oral FA-HMB increased muscle protein synthesis (MPS) and reduced muscle protein breakdown (MPB). The objective of the present study was to quantify muscle protein metabolism responses to oral Ca-HMB.

Methods: Eight healthy young males received a primed constant infusion of 1,2 13C2 leucine and 2H5 phenylalanine to assess MPS (by tracer incorporation in myofibrils) and MPB (via arterio-venous (A-V) dilution) at baseline and following provision of ∼3 g of Ca-HMB; muscle anabolic (MPS) and catabolic (MPB) signalling was assessed via immunoblotting.

Results: Ca-HMB led a significant and rapid (

Journal Article Type Article
Publication Date Oct 6, 2017
Journal Clinical Nutrition
Print ISSN 0261-5614
Electronic ISSN 1532-1983
Publisher Elsevier
Peer Reviewed Peer Reviewed
APA6 Citation Wilkinson, D. J., Hossain, T., Limb, M. C., Phillips, B. E., Lund, J., Williams, J. P., …Atherton, P. J. (2017). Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism. Clinical Nutrition, doi:10.1016/j.clnu.2017.09.024. ISSN 0261-5614
DOI https://doi.org/10.1016/j.clnu.2017.09.024
Keywords β-Hydroxy-β-methylbutyrate; Skeletal muscle; Protein metabolism; Anabolism
Publisher URL https://www.sciencedirect.com/science/article/pii/S0261561417313560
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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