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Impact of the calcium form of ?-hydroxy-?-methylbutyrate upon human skeletal muscle protein metabolism

Wilkinson, Daniel J.; Hossain, T.; Limb, Marie C.; Phillips, Bethan E.; Lund, J.; Williams, John P.; Brook, Matthew S.; Cegielski, Jessica; Philp, A.; Ashcroft, S.; Rathmacher, J. A.; Szewczyk, N. J.; Smith, K.; Atherton, Philip J.

Authors

T. Hossain

Marie C. Limb

BETH PHILLIPS beth.phillips@nottingham.ac.uk
Professor of Translational Physiology

JONATHAN LUND JON.LUND@NOTTINGHAM.AC.UK
Clinical Associate Professor

JOHN WILLIAMS john.williams7@nottingham.ac.uk
Clinical Associate Professor

Jessica Cegielski

A. Philp

S. Ashcroft

J. A. Rathmacher

N. J. Szewczyk

KENNETH SMITH KEN.SMITH@NOTTINGHAM.AC.UK
Professor of Metabolic Mass Spectrometry

PHILIP ATHERTON philip.atherton@nottingham.ac.uk
Professor of Clinical, metabolic & Molecular Physiology



Abstract

© 2017 The Authors Background & aims: β-hydroxy-β-methylbutyrate (HMB) is purported as a key nutritional supplement for the preservation of muscle mass in health, disease and as an ergogenic aid in exercise. Of the two available forms of HMB (calcium (Ca-HMB) salt or free acid (FA-HMB)) – differences in plasma bioavailability have been reported. We previously reported that ∼3 g oral FA-HMB increased muscle protein synthesis (MPS) and reduced muscle protein breakdown (MPB). The objective of the present study was to quantify muscle protein metabolism responses to oral Ca-HMB. Methods: Eight healthy young males received a primed constant infusion of 1,2 13C2 leucine and 2H5 phenylalanine to assess MPS (by tracer incorporation in myofibrils) and MPB (via arterio-venous (A-V) dilution) at baseline and following provision of ∼3 g of Ca-HMB; muscle anabolic (MPS) and catabolic (MPB) signalling was assessed via immunoblotting. Results: Ca-HMB led a significant and rapid (

Citation

Wilkinson, D. J., Hossain, T., Limb, M. C., Phillips, B. E., Lund, J., Williams, J. P., …Atherton, P. J. (2018). Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism. Clinical Nutrition, 37(6), 2068-2075. https://doi.org/10.1016/j.clnu.2017.09.024

Journal Article Type Article
Acceptance Date Sep 29, 2017
Online Publication Date Oct 6, 2017
Publication Date Dec 1, 2018
Deposit Date Nov 8, 2017
Publicly Available Date Mar 29, 2024
Journal Clinical Nutrition
Print ISSN 0261-5614
Electronic ISSN 1532-1983
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 37
Issue 6
Pages 2068-2075
DOI https://doi.org/10.1016/j.clnu.2017.09.024
Keywords ?-Hydroxy-?-methylbutyrate; Skeletal muscle; Protein metabolism; Anabolism
Public URL https://nottingham-repository.worktribe.com/output/886710
Publisher URL https://www.sciencedirect.com/science/article/pii/S0261561417313560
Additional Information This article is maintained by: Elsevier; Article Title: Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism; Journal Title: Clinical Nutrition; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.clnu.2017.09.024; Content Type: article; Copyright: © 2017 The Authors. Published by Elsevier Ltd.

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