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Prostacyclin, thromboxane and glomerular filtration rate are abnormal in sickle cell pregnancy

Obilade, Opeyemi Abayomi; Akanmu, Alani Suleimon; Broughton Pipkin, Fiona; Afolabi, Bosede Bukola

Authors

Opeyemi Abayomi Obilade

Alani Suleimon Akanmu

Fiona Broughton Pipkin fiona.broughton-pipkin@nottingham.ac.uk

Bosede Bukola Afolabi



Abstract

BACKGROUND: Pregnancy increases the risk of morbidity and mortality in sickle cell disease. We previously showed pregnant women with sickle cell disease to have a relatively low plasma renin concentration in late pregnancy, associated with a lack of the expected plasma volume expansion. We hypothesized this to be due to increased systemic vascular resistance through an imbalance between the vasodilator prostacyclin and vasoconstrictor thromboxane, associated with decreased glomerular filtration rate (GFR).
OBJECTIVE: To compare estimated prostacyclin, thromboxane and GFR in non-pregnant and pregnant women with hemoglobin SS (HbSS) and AA (HbAA).
STUDY DESIGN: Four groups of 20 normotensive, nulliparous women were studied in Lagos, Nigeria: pregnant HbSS or HbAA women at 36-40 weeks gestation; non-pregnant HbSS and HbAA controls. We measured stable metabolites of prostacyclin and thromboxane A2 by enzyme-linked immunosorbent assay; GFR using the Cockcroft-Gault equation. Data analysis was by independent (Student's) t-test or Mann-Whitney U test for comparisons between any two groups of continuous variables, univariate ANOVA for multiple groups and Pearson's correlation coefficient for degree of association between variables.
RESULTS: HbSS women had lower serum 6-keto-PGF1α concentrations than HbAA, whether pregnant or non-pregnant (P

Journal Article Type Article
Publication Date Sep 7, 2017
Journal PLoS ONE
Electronic ISSN 1932-6203
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 12
Issue 9
Article Number e0184345
APA6 Citation Obilade, O. A., Akanmu, A. S., Broughton Pipkin, F., & Afolabi, B. B. (2017). Prostacyclin, thromboxane and glomerular filtration rate are abnormal in sickle cell pregnancy. PLoS ONE, 12(9), doi:10.1371/journal.pone.0184345
DOI https://doi.org/10.1371/journal.pone.0184345
Publisher URL http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184345
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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