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Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies

O'Tuathaigh, C.M.P.; Moran, P.M.; Zhen, X.C.; Waddington, J.L.

Authors

C.M.P. O'Tuathaigh

P.M. Moran

X.C. Zhen

J.L. Waddington



Abstract

The presence and severity of cognitive symptoms, including working memory, executive dysfunction and attentional impairment, contributes materially to functional impairment in schizophrenia. Cognitive symptoms have proven resistant to both first- and second-generation antipsychotic drugs. Efforts to develop a consensus set of cognitive domains that are both disrupted in schizophrenia and are amenable to cross-species validation (e.g. the NIMH CNTRICS and RDoC initiatives) are an important step towards standardisation of outcome measures that can used in preclinical testing of new drugs. While causative genetic mutations have not been identified, new technologies have identified novel genes as well as hitherto candidate genes previously implicated in the pathophysiology of schizophrenia and/or mechanisms of antipsychotic efficacy. This review comprises a selective summary of these developments, particularly phenotypic data arising from preclinical genetic models for cognitive dysfunction in schizophrenia, with the aim of indicating potential new directions for pro-cognitive therapeutics.

Citation

O'Tuathaigh, C., Moran, P., Zhen, X., & Waddington, J. (in press). Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies. British Journal of Pharmacology, 174(19), https://doi.org/10.1111/bph.13938

Journal Article Type Article
Acceptance Date Jun 12, 2017
Online Publication Date Aug 3, 2017
Deposit Date Jun 21, 2017
Publicly Available Date Mar 29, 2024
Journal British Journal of Pharmacology
Print ISSN 0007-1188
Electronic ISSN 1476-5381
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 174
Issue 19
DOI https://doi.org/10.1111/bph.13938
Public URL https://nottingham-repository.worktribe.com/output/876522
Publisher URL http://onlinelibrary.wiley.com/doi/10.1111/bph.13938/abstract
Additional Information This is the peer reviewed version of the following article: O'Tuathaigh, C. M. P., Moran, P. M., Zhen, X. C., and Waddington, J. L. (2017) Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies. British Journal of Pharmacology, doi: 10.1111/bph.13938 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/bph.13938/full This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

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