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Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by release of a cationic serine protease inhibitor

Limón, David; Jiménez-Newman, Claire; Calpena, Ana C.; González-Campo, Arántzazu; Amabilino, David B.; Pérez-García, Lluïsa

Authors

David Limón

Claire Jiménez-Newman

Ana C. Calpena

Arántzazu González-Campo

David B. Amabilino

Lluïsa Pérez-García



Abstract

Gels formed by a gemini dicationic amphiphile incorporate a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affecting a number of gel properties but most importantly inducing remarkable fibre coiling at the microscopic level as a result of drug releasefrom the gel. Drug release and skin permeation experiments show its potential for topical administration.

Journal Article Type Article
Journal Chemical Communications
Print ISSN 1359-7345
Electronic ISSN 1364-548X
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 53
Issue 32
Pages 4509-4512
APA6 Citation Limón, D., Jiménez-Newman, C., Calpena, A. C., González-Campo, A., Amabilino, D. B., & Pérez-García, L. (in press). Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by release of a cationic serine protease inhibitor. Chemical Communications, 53(32), 4509-4512. https://doi.org/10.1039/C6CC09392B
DOI https://doi.org/10.1039/C6CC09392B
Publisher URL http://pubs.rsc.org/en/content/articlehtml/2017/cc/c6cc09392b
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information : This document is Similarity Check deposited; : Supplementary Information; : David B. Amabilino (ORCID); : Lluïsa Pérez-García (ORCID); : The Royal Society of Chemistry has an exclusive publication licence for this journal; : Single-blind; : Received 24 November 2016; Accepted 21 March 2017; Accepted Manuscript published 22 March 2017; Advance Article published 7 April 2017; Version of Record published 18 April 2017

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Manuscript - revised.pdf (722 Kb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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