Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by the release of a cationic serine protease inhibitor

Abstract

© The Royal Society of Chemistry. Gels formed by a gemini dicationic amphiphile incorporate a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affecting a number of gel properties but most importantly inducing remarkable fibre coiling at the microscopic level as a result of drug release from the gel. Drug release and skin permeation experiments show its potential for topical administration.

Citation

Limón, D., Jiménez-Newman, C., Calpena, A. C., González-Campo, A., Amabilino, D. B., & Pérez-García, L. (in press). Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by the release of a cationic serine protease inhibitor. Chemical Communications, 53(32), 4509-4512. https://doi.org/10.1039/C6CC09392B

• Journal Article Type: Article
• Acceptance Date: Mar 21, 2017
• Online Publication Date: Mar 22, 2017
• Deposit Date: Apr 23, 2018
• Publicly Available Date: Apr 23, 2018
• Journal: Chemical Communications
• Print ISSN: 1359-7345
• Electronic ISSN: 1364-548X
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 53
• Issue: 32
• Pages: 4509-4512
• DOI: https://doi.org/10.1039/C6CC09392B
• Public URL: https://nottingham-repository.worktribe.com/output/851901
• Publisher URL: http://pubs.rsc.org/en/content/articlehtml/2017/cc/c6cc09392b