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T cell immunoengineering with advanced biomaterials

Delcassian, Derfogail; Sattler, Susanne; Dunlop, Iain E.

Authors

Susanne Sattler

Iain E. Dunlop



Abstract

Recent advances in biomaterials design offer the potential to actively control immune cell activation and behaviour. Many human diseases, such as infections, cancer, and autoimmune disorders, are partly mediated by inappropriate or insufficient activation of the immune system. T cells play a central role in the host immune response to these diseases, and so constitute a promising cell type for manipulation. In vivo, T cells are stimulated by antigen presenting cells (APC), therefore to design immunoengineering biomaterials that control T cell behaviour, artificial interfaces that mimic the natural APC-T cell interaction are required. This review draws together research in the design and fabrication of such biomaterial interfaces, and highlights efforts to elucidate key parameters in T cell activation, such as substrate mechanical properties and spatial organization of receptors, illustrating how they can be manipulated by bioengineering approaches to alter T cell function.

Citation

Delcassian, D., Sattler, S., & Dunlop, I. E. (2017). T cell immunoengineering with advanced biomaterials. Integrative Biology, 9(3), https://doi.org/10.1039/c6ib00233a

Journal Article Type Article
Acceptance Date Feb 15, 2017
Online Publication Date Feb 20, 2017
Publication Date Mar 1, 2017
Deposit Date May 18, 2018
Publicly Available Date May 18, 2018
Journal Integrative Biology
Print ISSN 1093-4391
Electronic ISSN 1757-9694
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 9
Issue 3
DOI https://doi.org/10.1039/c6ib00233a
Public URL http://eprints.nottingham.ac.uk/id/eprint/51872
Publisher URL http://pubs.rsc.org/en/Content/ArticleLanding/2017/IB/C6IB00233A#!divAbstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Integrative Biology Review (T cell biomaterials).pdf (3.9 Mb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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