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Nanoscale engineering of hybrid magnetite–carbon nanofibre materials for magnetic resonance imaging contrast agents

Metelkina, Olga N.; Lodge, Rhys W.; Rudakovskaya, Polina G.; Gerasimov, Vasiliy M.; Lucas, Carlos H.; Grebennikov, Ivan S.; Shchetinin, Igor V.; Savchenko, Alexander G.; Pavlovskaya, Galina E.; Rance, Graham A.; del Carmen Gimenez-Lopez, Maria; Khlobystov, Andrei N.; Majouga, Alexander G.

Authors

Olga N. Metelkina

Polina G. Rudakovskaya

Vasiliy M. Gerasimov

Carlos H. Lucas

Ivan S. Grebennikov

Igor V. Shchetinin

Alexander G. Savchenko

Maria del Carmen Gimenez-Lopez

Alexander G. Majouga



Abstract

Magnetic nanomaterials show significant promise as contrast agents for magnetic resonance imaging (MRI). We have developed a new highly efficient one-step procedure for the synthesis of magnetically- functionalised hollow carbon nanofibres, where (i) the carbon nanofibres act as both a template and a support for the nucleation and growth of magnetite nanoparticles and (ii) the structural (size, dispersity and morphology) and functional (magnetisation and coercivity) properties of the magnetic nanoparticles formed on nanofibres are strictly controlled by the mass ratio of the magnetite precursor to the nanofibres and the solvent employed during synthesis. We have shown that our magnetite-nanofibre materials are effectively solubilised in water resulting in a stable suspension that has been employed as a ‘‘negative’’ MRI contrast agent with an excellent transverse relaxivity (r2) of (268 13) mM s 1, surpassing current commercial materials and state-of-the-art magnetic nanoscale platforms in performance for MRI contrast at high magnetic fields. The preparation and evaluation of this unique hybrid nanomaterial represents a critical step towards the realisation of a highly efficient ‘‘smart’’ MRI theranostic agent – a material that allows for the combined diagnosis (with MRI), treatment (with magnetic targeting) and follow-up of a disease (with MRI) – currently in high demand for various clinical applications, including stratified nanomedicine.

Journal Article Type Article
Publication Date Feb 28, 2017
Journal Journal of Materials Chemistry C
Print ISSN 2050-7526
Electronic ISSN 2050-7496
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 5
Issue 8
Pages 2167-2174
APA6 Citation Metelkina, O. N., Lodge, R. W., Rudakovskaya, P. G., Gerasimov, V. M., Lucas, C. H., Grebennikov, I. S., …Majouga, A. G. (2017). Nanoscale engineering of hybrid magnetite–carbon nanofibre materials for magnetic resonance imaging contrast agents. Journal of Materials Chemistry C, 5(8), 2167-2174. https://doi.org/10.1039/C6TC04141H
DOI https://doi.org/10.1039/C6TC04141H
Publisher URL https://pubs.rsc.org/en/content/articlelanding/2017/tc/c6tc04141h#!divAbstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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