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Scene-selective coding by single neurons in the human parahippocampal cortex

Mormann, Florian; Kornblith, Simon; Cerf, Moran; Ison, Matias J.; Kraskov, Alexander; Tran, Michelle; Knieling, Simeon; Quian Quiroga, Rodrigo; Koch, Christof; Fried, Itzhak

Authors

Florian Mormann

Simon Kornblith

Moran Cerf

Alexander Kraskov

Michelle Tran

Simeon Knieling

Rodrigo Quian Quiroga

Christof Koch

Itzhak Fried



Abstract

Imaging, electrophysiological, and lesion studies have shown a relationship between the parahippocampal cortex (PHC) and the processing of spatial scenes. Our present knowledge of PHC, however, is restricted to the macroscopic properties and dynamics of bulk tissue; the behavior and selectivity of single parahippocampal neurons remains largely unknown. In this study, we analyzed responses from 630 parahippocampal neurons in 24 neurosurgical patients during visual stimulus presentation. We found a spatially clustered subpopulation of scene-selective units with an associated event-related field potential. These units form a population code that is more distributed for scenes than for other stimulus categories, and less sparse than elsewhere in the medial temporal lobe. Our electrophysiological findings provide insight into how individual units give rise to the population response observed with functional imaging in the parahippocampal place area.

Citation

Mormann, F., Kornblith, S., Cerf, M., Ison, M. J., Kraskov, A., Tran, M., …Fried, I. (2017). Scene-selective coding by single neurons in the human parahippocampal cortex. Proceedings of the National Academy of Sciences, 114(5), https://doi.org/10.1073/pnas.1608159113

Journal Article Type Article
Acceptance Date Nov 4, 2016
Online Publication Date Jan 17, 2017
Publication Date Jan 31, 2017
Deposit Date Jul 31, 2017
Publicly Available Date Mar 29, 2024
Journal Proceedings of the National Academy of Sciences
Print ISSN 0027-8424
Electronic ISSN 1091-6490
Publisher National Academy of Sciences
Peer Reviewed Peer Reviewed
Volume 114
Issue 5
DOI https://doi.org/10.1073/pnas.1608159113
Keywords Electrophysiology, Single units, Scene selectivity, Population code
Public URL https://nottingham-repository.worktribe.com/output/838422
Publisher URL https://doi.org/10.1073/pnas.1608159113

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