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Responsiveness of SF-36 Health Survey and Patient Generated Index in people with chronic knee pain commenced on oral analgesia: analysis of data from a randomised controlled clinical trial

Papou, Alex; Hussain, Salma; McWilliams, Daniel F.; Zhang, Weiya; Doherty, Michael

Authors

Alex Papou

Salma Hussain

Daniel F. McWilliams

Michael Doherty



Abstract

Purpose. (1) to assess the responsiveness of the Short Form 36 Health Survey (SF-36) and Patient Generated Index (PGI) in people with knee pain who were given oral analgesics; and (2) to perform content analysis of the SF-36 and PGI aiming to identify differences between the instruments and causes of different responsiveness.
Methods. An observational study nested within a randomised controlled trial comparing oral paracetamol, ibuprofen or a combination of the two in 884 community-derived people with chronic knee pain. Each participant was given the SF-36 and PGI questionnaires to fill out at baseline, day 10, week 7 and week 13 after commencement on analgesia. Responsiveness was measured as a standardised response mean from baseline and contents of the instruments were analysed.
Results. The PGI showed the greater responsiveness to analgesics than the SF-36 throughout the study period. Only the Bodily Pain Score of the SF-36 showed comparable responsiveness to the PGI. The standardised response mean of the PGI at 13 weeks was 0.61 (95% confidence interval 0.51 to 0.72), and that of the Bodily Pain Score of the SF-36 was 0.49 (95% confidence interval 0.39 to 0.58). Content analysis of the PGI identified multiple areas which are not represented in the SF-36 which may help explain its performance.
Conclusions. Overall the PGI is more responsive than the SF-36 to commonly used oral analgesics taken for knee pain. The PGI is able to elicit areas of individualised health related quality of life which are not captured by the SF-36.

Citation

Papou, A., Hussain, S., McWilliams, D. F., Zhang, W., & Doherty, M. (in press). Responsiveness of SF-36 Health Survey and Patient Generated Index in people with chronic knee pain commenced on oral analgesia: analysis of data from a randomised controlled clinical trial. Quality of Life Research, https://doi.org/10.1007/s11136-016-1484-2

Journal Article Type Article
Acceptance Date Dec 8, 2016
Online Publication Date Dec 19, 2016
Deposit Date Jan 31, 2017
Publicly Available Date Jan 31, 2017
Journal Quality of Life Research
Print ISSN 0962-9343
Electronic ISSN 1573-2649
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1007/s11136-016-1484-2
Keywords knee pain, osteoarthritis, SF-36, Patient Generated Index, responsiveness, health-related quality of life
Public URL http://eprints.nottingham.ac.uk/id/eprint/40172
Publisher URL http://link.springer.com/article/10.1007%2Fs11136-016-1484-2
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf

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Copyright Statement
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