Philip J. Wiffen
Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults
Wiffen, Philip J.; Knaggs, Roger; Derry, Sheena; Cole, Peter; Phillips, Tudor; Moore, R. Andrew
Authors
ROGER KNAGGS Roger.Knaggs@nottingham.ac.uk
Associate Professor
Sheena Derry
Peter Cole
Tudor Phillips
R. Andrew Moore
Abstract
BACKGROUND
Paracetamol, either alone or in combination with codeine or dihydrocodeine, is commonly used to treat chronic neuropathic pain. This review sought evidence for efficacy and harm from randomised double-blind studies.
OBJECTIVES
To assess the analgesic efficacy and adverse events of paracetamol with or without codeine or dihydrocodeine for chronic neuropathic pain in adults.
SEARCH METHODS
We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, and Embase from inception to July 2016, together with reference lists of retrieved papers and reviews, and two online study registries.
SELECTION CRITERIA
We included randomised, double-blind studies of two weeks' duration or longer, comparing paracetamol, alone or in combination with codeine or dihydrocodeine, with placebo or another active treatment in chronic neuropathic pain.
DATA COLLECTION AND ANALYSIS
Two review authors independently searched for studies, extracted efficacy and adverse event data, and examined issues of study quality and potential bias. We did not carry out any pooled analyses. We assessed the quality of the evidence using GRADE.
MAIN RESULTS
No study satisfied the inclusion criteria. Effects of interventions were not assessed as there were no included studies. We have only very low quality evidence and have no reliable indication of the likely effect.
AUTHORS' CONCLUSIONS
There is insufficient evidence to support or refute the suggestion that paracetamol alone, or in combination with codeine or dihydrocodeine, works in any neuropathic pain condition.
Citation
Wiffen, P. J., Knaggs, R., Derry, S., Cole, P., Phillips, T., & Moore, R. A. (2016). Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults. Cochrane Database of Systematic Reviews, Article CD012227. https://doi.org/10.1002/14651858.CD012227.pub2
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 12, 2016 |
Publication Date | Dec 27, 2016 |
Deposit Date | Jan 22, 2018 |
Publicly Available Date | Jan 22, 2018 |
Journal | Cochrane Database of Systematic Reviews |
Electronic ISSN | 1469-493X |
Publisher | Cochrane Collaboration |
Peer Reviewed | Peer Reviewed |
Issue | 12 |
Article Number | CD012227 |
DOI | https://doi.org/10.1002/14651858.CD012227.pub2 |
Public URL | https://nottingham-repository.worktribe.com/output/832166 |
Publisher URL | http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD012227.pub2/abstract |
Files
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf
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