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Novel strategies for assessing platelet reactivity

Algahtani, Mohammad; Heptinstall, Stan

Authors

Mohammad Algahtani

Stan Heptinstall



Abstract

There are many approaches to assessing platelet reactivity and many uses for such measurements. Initially, measurements were based on the ability of platelets separated from other blood cells to aggregate together following activation with an appropriate ‘aggregating agent’. Later, measurements of platelet aggregation in blood itself were performed, and this led to a point-of-care approach to platelet function testing. Measurement of secretory activity through the appearance of the activation marker P-selectin on platelets now provides an alternative approach, which enables remote testing.
Measurement of vasodilator-stimulated phosphoprotein phosphorylation is also moving toward application in situations remote from the testing laboratory. Here we provide an overview of the various approaches that are now available, assess their advantages and disadvantages, and describe some of the clinical situations in which they are being used.

Citation

Algahtani, M., & Heptinstall, S. (2017). Novel strategies for assessing platelet reactivity. Future Cardiology, 13(1), https://doi.org/10.2217/fca-2016-0054

Journal Article Type Article
Acceptance Date Nov 9, 2016
Online Publication Date Dec 19, 2016
Publication Date Jan 1, 2017
Deposit Date Feb 10, 2017
Publicly Available Date Feb 10, 2017
Journal Future Cardiology
Print ISSN 1479-6678
Electronic ISSN 1479-6678
Publisher Future Medicine
Peer Reviewed Peer Reviewed
Volume 13
Issue 1
DOI https://doi.org/10.2217/fca-2016-0054
Keywords aspirin ; flow cytometry ; light transmission
aggregometry ; LTA ; MEA ; multiplate electrode
aggregometry ; P-selectin ; P2Y12 antagonists ; platelet aggregation ; platelet reactivity ; VASP phosphorylation ; VerifyNow
Public URL http://eprints.nottingham.ac.uk/id/eprint/40527
Publisher URL http://www.futuremedicine.com/doi/10.2217/fca-2016-0054
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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