Novel strategies for assessing platelet reactivity

Algahtani, Mohammad; Heptinstall, Stan

Abstract

There are many approaches to assessing platelet reactivity and many uses for such measurements. Initially, measurements were based on the ability of platelets separated from other blood cells to aggregate together following activation with an appropriate ‘aggregating agent’. Later, measurements of platelet aggregation in blood itself were performed, and this led to a point-of-care approach to platelet function testing. Measurement of secretory activity through the appearance of the activation marker P-selectin on platelets now provides an alternative approach, which enables remote testing.
Measurement of vasodilator-stimulated phosphoprotein phosphorylation is also moving toward application in situations remote from the testing laboratory. Here we provide an overview of the various approaches that are now available, assess their advantages and disadvantages, and describe some of the clinical situations in which they are being used.

Citation

Algahtani, M., & Heptinstall, S. (2017). Novel strategies for assessing platelet reactivity. Future Cardiology, 13(1), https://doi.org/10.2217/fca-2016-0054

• Journal Article Type: Article
• Acceptance Date: Nov 9, 2016
• Online Publication Date: Dec 19, 2016
• Publication Date: Jan 1, 2017
• Deposit Date: Feb 10, 2017
• Publicly Available Date: Feb 10, 2017
• Journal: Future Cardiology
• Print ISSN: 1479-6678
• Electronic ISSN: 1479-6678
• Publisher: Future Medicine
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Issue: 1
• DOI: https://doi.org/10.2217/fca-2016-0054
• Keywords: aspirin ; flow cytometry ; light transmission; aggregometry ; LTA ; MEA ; multiplate electrode; aggregometry ; P-selectin ; P2Y12 antagonists ; platelet aggregation ; platelet reactivity ; VASP phosphorylation ; VerifyNow
• Public URL: https://nottingham-repository.worktribe.com/output/830428
• Publisher URL: http://www.futuremedicine.com/doi/10.2217/fca-2016-0054