Emma C. Stevenson
Coinfection and Emergence of Rifamycin Resistance during a Recurrent Clostridium difficile Infection
Stevenson, Emma C.; Major, Giles A.; Spiller, Robin C.; Kuehne, Sarah A.; Minton, Nigel P.
Authors
Giles A. Major
ROBIN SPILLER ROBIN.SPILLER@NOTTINGHAM.AC.UK
Professor of Gastroenterology
Sarah A. Kuehne
Professor NIGEL MINTON nigel.minton@nottingham.ac.uk
Professor of Applied Molecular Microbiology
Contributors
B. A. Forbes
Editor
Abstract
Clostridium difficile (Peptoclostridium difficile) is a common health care-associated infection with a disproportionately high incidence in elderly patients. Disease symptoms range from mild diarrhea to life-threatening pseudomembranous colitis. Around 20% of patients may suffer recurrent disease, which often requires rehospitalization of patients. C. difficile was isolated from stool samples from a patient with two recurrent C. difficile infections. PCR ribotyping, whole-genome sequencing, and phenotypic assays were used to characterize these isolates. Genotypic and phenotypic screening of C. difficile isolates revealed multiple PCR ribotypes present and the emergence of rifamycin resistance during the infection cycle. Understanding both the clinical and bacterial factors that contribute to the course of recurrent infection could inform strategies to reduce recurrence. (This study has been registered at ClinicalTrials.gov under registration no. NCT01670149.)
Citation
Stevenson, E. C., Major, G. A., Spiller, R. C., Kuehne, S. A., & Minton, N. P. (2016). Coinfection and Emergence of Rifamycin Resistance during a Recurrent Clostridium difficile Infection. Journal of Clinical Microbiology, 54(11), 2689-2694. https://doi.org/10.1128/jcm.01025-16
Journal Article Type | Article |
---|---|
Acceptance Date | Aug 15, 2016 |
Online Publication Date | Aug 24, 2016 |
Publication Date | Nov 15, 2016 |
Deposit Date | Oct 4, 2016 |
Publicly Available Date | Oct 4, 2016 |
Journal | Journal of Clinical Microbiology |
Print ISSN | 0095-1137 |
Electronic ISSN | 1098-660X |
Publisher | American Society for Microbiology |
Peer Reviewed | Peer Reviewed |
Volume | 54 |
Issue | 11 |
Pages | 2689-2694 |
DOI | https://doi.org/10.1128/jcm.01025-16 |
Public URL | https://nottingham-repository.worktribe.com/output/828620 |
Publisher URL | http://jcm.asm.org/content/54/11/2689 |
Contract Date | Oct 4, 2016 |
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