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Phosphonium polymers for gene delivery

Loczenski Rose, Vanessa; Mastrotto, Francesca; Mantovani, Giuseppe

Authors

Vanessa Loczenski Rose vanessa. loczenski_rose@syngenta. com

Francesca Mastrotto francesca.mastrotto@nottingham.ac.uk



Abstract

Phosphonium salt-containing polymers have very recently started to emerge as attractive materials for the engineering non-viral gene delivery systems. Compared to more frequently utilised ammonium-based polymers, some of these materials can enhance binding of nucleic acid at lower polymer concentration, and mediate good transfections efficiency, with low cytotoxicity. However, for years one of the main hurdles for their widespread application has been the lack of general routes for their synthesis. To date a range of polymerisation techniques have been explored, with the majority of them focussing on radical polymerisation, especially controlled radical polymerisation (CRP) techniques – ATRP, NMP and RAFT polymerisation - both by polymerisation of phosphonium monomers or by post-polymerisation modification of polymer intermediates. This review article aims at discussing key differences and similarities between phosphonium-and other analogous cations, how these affect binding to polynucleotides, and will provide an overview of the phosphonium polymer systems that have been utilised for gene delivery.

Journal Article Type Article
Journal Polymer Chemistry
Print ISSN 1759-9954
Electronic ISSN 1759-9962
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 8
APA6 Citation Loczenski Rose, V., Mastrotto, F., & Mantovani, G. (in press). Phosphonium polymers for gene delivery. Polymer Chemistry, 8, https://doi.org/10.1039/C6PY01855F
DOI https://doi.org/10.1039/C6PY01855F
Publisher URL http://pubs.rsc.org/en/content/articlepdf/2017/py/c6py01855f
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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